Characterization of extrachromosomal circular DNA in cattle using 676 whole genome sequencing datasets

Abstract

Other than the commonly known linear DNA in the eukaryotic nucleus, DNA can have a circular form that is similar to mitochondrial DNA (Saccone et al., 2000;Sakamoto & Takami, 2018). This was named extrachromosomal circular DNA (eccDNA; Liao et al., 2020). The eccDNA was first reported in mammals and plants as early as 1965(Hotta & Bassel, 1965. To date, the existence of eccDNA has been observed in many eukaryotes (