2015
DOI: 10.4103/2141-9248.160192
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Characterization of Escherichia coli phylogenetic groups associated with extraintestinal infections in South Indian population

Abstract: Background:Escherichia coli strains mainly fall into four phylogenetic groups (A, B1, B2, and D) and that virulent extra-intestinal strains mainly belong to groups B2 and D.Aim:The aim was to determine the association between phylogenetic groups of E. coli causing extraintestinal infections (ExPEC) regarding the site of infection, expression of virulence factors, antimicrobial resistance patterns, and clinical outcome. This descriptive study was carried out in a multi-specialty Tertiary Care Hospital.Materials… Show more

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Cited by 68 publications
(36 citation statements)
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“…Using reference genomes and pathogenicity annotations from the PATRIC database (Wattam et al , 2014), we noted that these two subspecies were significantly enriched in isolates that caused diseases in the human host. These findings are in line with results on the corresponding phylogroups D and B2 (MGSS3 and MGSS4, respectively), which have been associated with extraintestinal infections in humans (Chakraborty et al , 2015). Moreover, metagenomic data from a recent enterohemorrhagic E. coli outbreak (Loman et al , 2013) indicates that the pathogenic strain comes from one of these two subspecies (Fig EV4).…”
Section: Resultssupporting
confidence: 90%
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“…Using reference genomes and pathogenicity annotations from the PATRIC database (Wattam et al , 2014), we noted that these two subspecies were significantly enriched in isolates that caused diseases in the human host. These findings are in line with results on the corresponding phylogroups D and B2 (MGSS3 and MGSS4, respectively), which have been associated with extraintestinal infections in humans (Chakraborty et al , 2015). Moreover, metagenomic data from a recent enterohemorrhagic E. coli outbreak (Loman et al , 2013) indicates that the pathogenic strain comes from one of these two subspecies (Fig EV4).…”
Section: Resultssupporting
confidence: 90%
“…Of the other three, for which population genetic studies have been published, one, Escherichia , was previously described to have well‐defined structure below the species level (Chakraborty et al , 2015). In comparison with the four subspecies of E. coli determined here, there is an exact correspondence, such that MGSS1, MGSS2, MGSS3, and MGSS4 recapitulate phylogroups B1, A, D, and B2, respectively (Materials and Methods, Table EV4).…”
Section: Resultsmentioning
confidence: 99%
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“…In diarrheagenic cases, EPEC isolates depicted a strong association with phylogroup B2 which is in accordance with other previously reported study, followed by B1, A, D, F, C, and E (Chakraborty et al, 2015). Six (diarrheagenic cases) and two (healthy control) isolates remained unclassified, which could either be due to their rarity of occurrence or a high frequency of loss of gene leading to low existence of these phylogroups (Touchon et al, 2009).…”
Section: Discussionsupporting
confidence: 92%
“…The prevalence of phylogenetic groups among the isolates of three investigated groups is shown in Table 2. Phylogenetic group B2 was the most prevalent group among urine isolates followed by D, a finding in agreement with several studies which indicated that ExPEC strains belonged mostly to group B2 and D (Chakraborty et al, 2015;Nielsen, Dynesen, Larsen, & Frimodt-Møller, 2014). Contrary to our expectations, there was a significant difference between urine and fecal isolates of the patients concerning the distribution of phylogenetic groups (p < 0.05).…”
Section: Phylogenetic Analysissupporting
confidence: 89%