Characterization of ergot and non-ergot serotonin antagonists by prolactin and growth hormone profiles during wakefulness and sleep

Clarenbach, P.; Pozo, E. del; Brownell, Judith; Heredia, E.N; Spiegel, René; Cramer, H.

doi:10.1016/0006-8993(80)90147-x

Cited by 9 publications

(1 citation statement)

References 15 publications

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“…It did not, however, report on specific effects (positive or negative) on breathing during sleep, and this should theoretically be considered, particularly as methysergide has been experimentally shown to abolish hypoglossal atonia seen during carbichol-induced, REM-like sleep (28), without affecting REM sleep generation in animal models (29). Methysergide and pizotifen also have differential effects on the circadian secretion profiles of both growth hormone and prolactin, with methysergide attenuating the nocturnal surge in prolactin and increasing the amplitude of growth hormone secretion, whereas pizotifen has no effect (30). No studies have examined their effects on melatonin physiology.…”

Section: Preventive Headache Medicationsmentioning

confidence: 99%

Headache, drugs and sleep

2014

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Medications used to treat headache disorders may have a considerable impact on sleep physiology. However, greater attention is needed to characterise the direction of the changes of these effects on sleep, particularly to avoid exacerbating detrimental sleep complaints, but also to potentially capitalise on homeostatically useful properties of sleep which may reduce the individual burden of headache disorders on patients.

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Section: Preventive Headache Medicationsmentioning

confidence: 99%