Characterization of eight Y-STR loci and haplotypes in a Chinese Han population

Tang, Jiajing; Hou, Yiping; Li, Ying Bi; Jin, Wook; Zhang, Jian; Zhang, Hai Jun

doi:10.1007/s00414-003-0371-x

Cited by 11 publications

(14 citation statements)

References 17 publications

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“…Two individuals, a father/son pair (designated samples 1 and 2, respectively, herein), that exhibited allele 18 at the DYS448 locus were selected and sequenced to serve as a reference for alignment ( Table 2). The sequences obtained for samples 1 and 2 were consistent with the basic structure of the locus and the same as that reported by Tang et al [26]. The only difference was that the son had a SNP at the fifth repeat resulting in the hexanucleotide AGAGGT.…”

Section: Resultssupporting

confidence: 84%

Null allele sequence structure at the DYS448 locus and implications for profile interpretation

Budowle

Aranda

Lagacé³

et al. 2008

Int J Legal Med

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Null alleles can occur with any PCR-based STR typing system. They generally are due to deletions within the target region or primer binding sites or by primer binding site mutations that destabilize hybridization of at least one of the primers flanking the target region. Although not common, null types were detected at the DYS448 locus in seven out of 1,005 unrelated males in the Hispanic population. Of these DYS448 null types, four individuals displayed an apparent duplication at the DYS437 locus. The additional allele observed at the DYS437 locus is in actuality a smaller-sized DYS448 amplicon, which is the result of a deletion of the invariant N42 base pair domain and downstream repeats within the DYS448 locus. Thus, some DYS448 null types are not truly null. A true DYS448 null allele carried numerous primer binding site variants and a large deletion including the N42 base pair domain and surrounding or downstream repeat regions. The presence of null alleles is not a real concern for interpretation of Y STR loci evidence; current methods for interpreting Y STR profiles easily accommodate such phenomena.

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Section: Resultssupporting

confidence: 84%

Null allele sequence structure at the DYS448 locus and implications for profile interpretation

Budowle

Aranda

Lagacé³

et al. 2008

Int J Legal Med

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“…The anthropologist studied human migration and evolution by comparing the genetic distance and by clustering among different populations using Y-STR loci. Y-STR loci have been recognized as very useful tools because of some specific properties compared with autosomal STR loci [5,6]. They can be used to analyze mixed stains in sexual assault cases, especially analysis of azoospermia semen samples from vasectomized men.…”

Section: Introductionmentioning

confidence: 99%

Y-chromosomal STR haplotypes in Chinese Uigur ethnic group

Zhu

Wang

Yang³

et al. 2005

Int J Legal Med

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We have already coamplified minimal haplotypes (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II), two additional loci, namely, DYS438, DYS439, and Amelogenin, in a single PCR using the Y-PLEX 12 kit. We investigated 107 unrelated male individuals from the Uigur ethnic group and studied the allelic frequency distribution and haplotype diversity of 11 Y-chromosomal STRs. A number of 43 alleles (nine STR loci) and 27 phenotypes (including DYS385) were detected, with frequencies ranging from 0.0092 to 0.6296. A total of 103 haplotypes were identified, among which 99 were individual-specific and four haplotypes were found twice. The haplotype diversity for these 12 Y-STR loci was 0.9993.

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“…In this regard, since Korea and Japan lie between the southeast and northeast Asian gene pools, their population genetic data can also give us valuable information about the prehistoric migration route(s) and population expansions in east Asia. Although several databases of Y-STRs have been published and are highly contributed to the field of population and forensic genetics in east Asia (Shin et al 2001;Tsai et al 2002;Tang et al 2003;Uchihi et al 2003), the amount of data for a combining Y-haplotypes from diverse regions of Asia is still limited.…”

Section: Introductionmentioning

confidence: 99%

Y-chromosomal STR haplotypes and their applications to forensic and population studies in east Asia

et al. 2005

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We have analyzed 11 Y-STR loci (DYS19, the two DYS385 loci, DYS388, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DXYS156Y) in 700 males from ten ethnic groups in east Asia in order to evaluate their usefulness for forensic and population genetic studies. A total of 644 different haplotypes were identified, among which 603 (86.14%) were individual-specific. The haplotype diversity averaged over all populations was 0.9997; using only the nine Y-STRs comprising the "minimal haplotype" (excluding DYS388 and DXYS156Y) it was 0.9996, a value similar to that found in 1924 samples from other Asian populations (0.9996; Lessig et al. Legal Medicine 5(2003) 160-163), and slightly higher than in European populations (0.9976; n=11,610; Roewer et al. For Sci International (2001) 118:103-111). All of the individual east Asian populations examined here had high haplotype diversity (> or =0.997), except for the Mongolians (0.992) and Manchurians (0.960). The most frequent haplotype identified by the nine markers was present at only 1% (7/700). Population comparisons based on Phi(ST) or rho genetic distance measures revealed clustering according to the traditional northeast-southeast distinction, but with exceptions. For example, the Yunnan population from southern China lay among the northern populations, possibly reflecting recent migration, while the Korean population, traditionally considered northern, lay at the boundary between northern and southern populations. An admixture estimate suggested 55(51-59)% northern, 45(41-49)% southern contribution to the Koreans, illustrating the complexity of the genetic history of this region.

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Characterization of eight Y-STR loci and haplotypes in a Chinese Han population

Cited by 11 publications

References 17 publications

Null allele sequence structure at the DYS448 locus and implications for profile interpretation

Null allele sequence structure at the DYS448 locus and implications for profile interpretation

Y-chromosomal STR haplotypes in Chinese Uigur ethnic group

Y-chromosomal STR haplotypes and their applications to forensic and population studies in east Asia

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