Characterization of early gastric cancer and proposal of the optimal therapeutic strategy

Shimada, Shinya; Yagi, Yasushi; Shiomori, Kenji; Honmyo, Ubehiko; Hayashi, Naoki; Matsuo, Akinobu; Marutsuka, Takashi; Ogawa, Michio

doi:10.1067/msy.2001.114217

Cited by 70 publications

(43 citation statements)

References 24 publications

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“…It is well known that the depth of the tumor and the presence of lymph node metastasis has a strong positive correlation. Our recent study demonstrated that invasion of the submucosal layer was one of the major factors related to lymph node metastasis [22]. In that study [22] the submucosal carcinomas were classified into three groups according to depth of invasion, by dividing the SM layer into three groups according to depth of invasion, by dividing the SM layer into three equal parts: upper (SM1), middle (SM2), and lower (SM3).…”

Section: Discussionmentioning

confidence: 99%

“…Our recent study demonstrated that invasion of the submucosal layer was one of the major factors related to lymph node metastasis [22]. In that study [22] the submucosal carcinomas were classified into three groups according to depth of invasion, by dividing the SM layer into three groups according to depth of invasion, by dividing the SM layer into three equal parts: upper (SM1), middle (SM2), and lower (SM3). The three subgroups of SM had a strong positive correlation with the rate of lymph node metastasis (P Ͻ 0.001), with an incidence of 10%, 19%, and 33% in SM1, SM2, and SM3, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma

Shimada

Yagi²,

Honmyo

et al. 2001

Gastric Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma

Shimada

Yagi²,

Honmyo

et al. 2001

Gastric Cancer

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“…The prognosis of patients with EGC after curative surgery is highly favorable with reported 5-year survival rates in the excess of 90% [3], therefore, the quality of lives of these patients has greatly been emphasized [4]. Considering the quality of life (QOF), endoscopic mucosal resection/r endoscopic submucosal dissection (EMR/ESD) is now widely accepted for mucosal gastric cancers without lymph node metastasis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Is gastrectomy mandatory for all residual or recurrent gastric cancer following endoscopic resection? a large‐scale Korean multi‐center study

Song

Hyung

Kim

et al. 2008

Journal of Surgical Oncology

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Background and Objectives: To clarify optimal treatment guidelines for residual or local recurrence after endoscopic resection (ER). Methods: Eighty-six patients underwent gastrectomy due to incomplete ER and local recurrence after ER. The pathological findings of ER and gastrectomy specimens were analyzed. Results: The cause of gastrectomy was categorized into five groups; submucosal (sm) invasion without margin involvement, positive margin, margin not evaluable, high risk of lymph node metastasis and local recurrence after ER. According to the pathological findings of gastrectomy specimens, remnant cancer and lymph node metastases were found in 56 (65.1%) and in 5 patients (5.8%), respectively. At 10 gastrectomy specimens which were sm invasion without margin involvement, the scattered residual cancer cells were found around the ulcer scar in 2 (20%) patients. In 11 of 44 margin involvement specimens, no residual cancer or lymph node metastasis was found. In patients with local recurrence, mean duration from ER to surgery was 14.8 months, and 19% of patients were found to have sm or deeper depth of invasion. Conclusion: Gastrectomy with lymph node dissection should be performed in patients with sm invasion with or without margin involvement. However, minimal approach other than gastrectomy could further be applied to selected patients.

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“…Если 10-15 лет назад объем хирургического лечения при резектабельном РЖ не опре-делялся клинической стадией заболевания (I-III) и субтоталь-ная резекция желудка или гастрэктомия в сочетании с лимфаден-эктомией (ЛАЭ) D2 рассматривалась как стандарт лечения паци-ентов с РРЖ, то в настоящее время активно применяют методы эндоскопической резекции слизистой оболочки с диссекцией в подслизистом слое [12,13].…”

Section: диагностика и эндоскопическое лечениеunclassified

“…Риск лимфогенного метастазирования увели-чивается у пациентов с диаметром опухоли 50 мм и более [24]. При наличии изъязвления в опухоли истинную глубину инвазии оценить сложно, поэтому частота лимфогенного метастазирова-ния при изъязвленных опухолях, расцененных как T1m, достига-ет 4,8% [12]. Кроме того, представляет сложности оценка риска лимфогенного метастазирования при недифференцированных формах РРЖ [25].…”

Section: особенности лимфогенного метастазирования и выбор объема лимunclassified

Current approaches to the diagnosis and treatment of early gastric cancer

Ryabov¹,

Соколов²,

Khomyakov³

et al. 2015

Onkol. Z. im. P.A. Gercena

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Рассмотрено современное состояние проблемы диагностики и лечения раннего рака желудка. Описаны различные ме-тоды эндоскопического исследования желудка, в том числе основанные на различных физических методах улучшения визуализации. Дана оценка предикторам лимфогенного метастазирования. На основании данных крупных клинических исследований сформулированы показания и противопоказания к различным видам хирургического лечения раннего рака желудка (эндоскопическим, малоинвазивным, открытым операциям). Ключевые слова: ранний рак желудка, эндоскопическая диагностика и лечение, предикторы лимфогенного метастазиро-вания, хирургическое лечение.The paper considers the state-of-the-art of the diagnosis and treatment of early gastric cancer. It describes various gastric endoscopic techniques, including those based on different physical methods for imaging improvement. The predictors of lymphatic cancer spread are assessed. Based on the data of large clinical trials, the authors formulated indications for and contraindications to different surgical treatment options (endoscopic, minimally invasive, open-access operations) for early gastric cancer.Key words: early gastric cancer, endoscopic diagnosis and treatment, predictors of lymphatic cancer spread, surgical treatment.

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Characterization of early gastric cancer and proposal of the optimal therapeutic strategy

Cited by 70 publications

References 24 publications

Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma

Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma

Is gastrectomy mandatory for all residual or recurrent gastric cancer following endoscopic resection? a large‐scale Korean multi‐center study

Current approaches to the diagnosis and treatment of early gastric cancer

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