Characterization of Early Gamma Interferon (IFN-γ) Expression during Murine Listeriosis: Identification of NK1.1+CD11c+Cells as the Primary IFN-γ-Expressing Cells

Chang, Shu-Rung; Wang, Kung-Jiun; Yan-feng, LU; Yang, Li‐Chin; Chen, Weijie; Lin, Yu‐Hsiang; Chang, Hsin-Hou; Wang, Shih-Lien

doi:10.1128/iai.01026-06

Cited by 17 publications

(23 citation statements)

References 34 publications

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“…However, we show here that HKLm is not an efficient inducer of IFN-γ in PyL infected mice and can not provide efficient protection against PyL infection as live Lm does. Our data are in accordance with Chang et al's report that the IFN-γ expression in Lm infected mice is absolutely dependent on live Lm infection and no IFN-γ can be detected after inoculation of HKLm (Chang et al 2007). Recent finding suggests that Lm killed by gamma-irradiation has similar effects as live bacteria in the induction of protective immunity (Datta et al 2006).…”

Section: Discussionsupporting

confidence: 93%

“…HKLm was reported less capable of inducing IL-12 and IFN-γ production than did the live Lm (Emoto et al 1997;Zhan and Cheers 1998;Chang et al 2007). To elucidate the roles these two cytokines played in the immunomodulatory effect of Lm on PyL infection, we inoculated PyL-infected C57BL/6 mice with HKLm and Lm, respectively.…”

Section: Live Lm Is Required To Induce a Th1-prone Cytokine Environmementioning

confidence: 99%

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Listeria monocytogenes Inoculation Protects Mice against Blood-Stage Plasmodium yoelii Infection

Han

Zhang

et al. 2013

Tohoku J. Exp. Med.

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Listeria monocytogenes (Lm) has been used as the adjuvant or vector for tumor and viral vaccine for its capability of eliciting all aspects of cell-mediated immunity including T cell activation and interferon-gamma (IFN-γ) production. These effector components play critical roles in the protection against Plasmodium infection in both human malaria and mouse models. Therefore, immune response induced by Lm infection may benefit the defense against malaria. To test this hypothesis, we employed blood-stage Plasmodium yoelii (PyL) infected mice and challenged them with Lm. C57BL/6 and BALB/c mice that are sensitive to PyL infection were used in experiments. These two strains are resistant and sensitive, respectively, to Lm infection. The outcomes of double infection with PyL and Lm and the changes of immune response were investigated. We found that live Lm inoculation inhibited PyL multiplication in both C57BL/6 and BALB/c mice. Lm inoculation increased production of IFN-γ, infiltration of CD11b-positive macrophages and generation of nitric oxide in the spleen of C57BL/6 mice at day 5 after parasite infection. Both CD4-and CD8-positive T cells contributed to IFN-γ production induced by Lm inoculation in PyL-infected mice. The protective effect of Lm against PyL infection depended on the viability of the bacteria. Live Lm, rather than heat-killed Lm, stimulated early IFN-γ production which provided essential cytokine environment for the development of Th1 response in PyL-infected mice. Our data show for the first time that Lm inoculation has protective effect against blood-stage murine malaria, which provides a new clue for enhancing antiPlasmodium immunity.

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Section: Discussionsupporting

confidence: 93%

Section: Live Lm Is Required To Induce a Th1-prone Cytokine Environmementioning

confidence: 99%

Listeria monocytogenes Inoculation Protects Mice against Blood-Stage Plasmodium yoelii Infection

Han

Zhang

et al. 2013

Tohoku J. Exp. Med.

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“…NKDC are now recognized as a novel immunologic cell type with pleiotropic functions (3)(4)(5)(6)(7)(8). Originally, Homann et al (22) reported murine DX5…”

Section: Discussionmentioning

confidence: 99%

NK Dendritic Cells Expanded in IL-15 Exhibit Antitumor Responses In Vivo

Chaudhry

Plitas

Burt

et al. 2007

The Journal of Immunology

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NK dendritic cells (NKDC) are a novel subtype of DC with NK cell properties. IL-15 is a pleiotropic cytokine that plays an obligate role in the proliferation and survival of NK cells. We hypothesized that IL-15 is also essential for NKDC development. NKDC were nearly absent in IL-15−/− mice, but restored by administration of exogenous IL-15. Treatment of wild-type mice with IL-15 caused a 2- to 3-fold expansion of both NK cells and NKDC. After 7 days of culture with IL-15, sorted splenic NKDC expanded 10-fold while NK cells increased 5-fold. NKDC expanded in IL-15 retained their cytolytic capacity but lost the ability to stimulate naive T cells. Meanwhile, NKDC expanded in IL-15 produced 10 times more IFN-γ as fresh NKDC and conferred protection in a tumor prevention model. Thus, IL-15 is essential to the proliferation and survival of NKDC and IL-15 expanded NKDC possess antitumor properties.

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“…Since infection with either Lm or Lm ⌬actA triggers the production of IFN-␥ by NK1.1 ϩ cells in the first 24 h after infection, the IFN-␥ these cells produce might be a key factor that inhibits CD4 Th17 differentiation while facilitating Th1 differentiation in WT mice (26,27). Moreover, because both IL-12 and IFN-I can induce IFN-␥ production by NK cells (28,29), we reasoned that a loss of early IFN-␥ production might contribute to the observed deviation from a Th1 to a Th17 response in mice with defects in these cytokine pathways.…”

Section: Ifn-␥ and Ifn-i Inhibit Th17 Differentiation In Response To mentioning

confidence: 99%

Deviation from a Strong Th1-Dominated to a Modest Th17-Dominated CD4 T Cell Response in the Absence of IL-12p40 and Type I IFNs Sustains Protective CD8 T Cells

Orgun

Mathis

Wilson

et al. 2008

The Journal of Immunology

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The differentiation of naive CD4 T cells into specific effector subsets is controlled in large part by the milieu of cytokines present during their initial encounter with Ag. Cytokines that drive differentiation of the newly described Th17 lineage have been characterized in vitro, but the cytokines that prime commitment to this lineage in response to infection in vivo are less clear. Listeria monocytogenes (Lm) induces a strong Th1 response in wild-type mice. By contrast, we demonstrate that in the absence of IL-12p40 (or IFN-γ) and type I IFN receptor signaling, the Th1 Ag-specific CD4 T cell response is virtually abolished and replaced by a relatively low magnitude Th17-dominated response. This Th17 response was dependent on TGF-β and IL-6. Despite this change in CD4 T cell response, neither the kinetics of the CD4 and CD8 T cell responses, the quality of the CD8 T cell response, nor the ability of CD8 T cells to mediate protection were affected. Thus, generation of protective CD8 T cell immunity was resilient to perturbations that replace a strong Th1-dominated to a reduced magnitude Th17-dominated Ag-specific CD4 T cell response.

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Characterization of Early Gamma Interferon (IFN-γ) Expression during Murine Listeriosis: Identification of NK1.1⁺CD11c⁺Cells as the Primary IFN-γ-Expressing Cells

Abstract: Though it is well established that gamma interferon (IFN-␥

Cited by 17 publications

References 34 publications

<i>Listeria monocytogenes</i> Inoculation Protects Mice against Blood-Stage <i>Plasmodium yoelii</i> Infection

<i>Listeria monocytogenes</i> Inoculation Protects Mice against Blood-Stage <i>Plasmodium yoelii</i> Infection

NK Dendritic Cells Expanded in IL-15 Exhibit Antitumor Responses In Vivo

Deviation from a Strong Th1-Dominated to a Modest Th17-Dominated CD4 T Cell Response in the Absence of IL-12p40 and Type I IFNs Sustains Protective CD8 T Cells

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