Characterization of drug–chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry

Boonsongrit, Yaowalak; Mueller, Bernd W.; Mitrevej, Ampol

doi:10.1016/j.ejpb.2007.11.008

Cited by 135 publications

(75 citation statements)

References 26 publications

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“…Chitosan 900 Stretching of C-O from: C-O-H; symmetric and asymmetric stretch from C-O-C bridge [46] 1075 Saccharide structure of chitosan and C-O stretching [47,48] 1157 Saccharide structure of chitosan and anti-symmetric stretching from C-O-C bridge [47,48] …”

Section: ) Assignment Referencementioning

confidence: 99%

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

et al. 2015

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Abstract:In the present study, silane-functionalized graphene (f-graphene)-reinforced chitosan nanocomposite films exhibiting enhanced mechanical properties have been prepared by the solution casting method. These nanocomposite films were characterized by X-ray diffraction, Raman spectroscopy and thermogravimetric analysis. In order to investigate the effect of silane functionalization, tensile tests were performed on original, oxidized and silane-functionalized graphene-reinforced chitosan nanocomposite films. Tensile results show that silane functionalization groups offer a substantial increase in the interfacial adhesion between filler and host matrix. This result is also confirmed by the surface morphology of the fracture surface in scanning electron microscope analysis. Qualitative analysis using Raman and Fourier transform infrared spectroscopy revealed the existence of Si-O-Si and Si-O-C bonds in the silanized composite. Thermal analysis of the samples shows that the material is stable up till 250 °C and maintains its thermal stability all throughout the process until it starts degrading after 510 °C. Atomic force microscopy reveals that the material is well exfoliated after the oxidation of graphene and also displays the existence of 3-6 layers of exfoliated graphene sheets. X-ray photoelectron spectroscopy studies also reveal the existence of silicon in the single state and quantify the sample to be approximately around 4% (±0.5%) of the total atomic weight. OPEN ACCESSPolymers 2015, 7 528

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Section: ) Assignment Referencementioning

confidence: 99%

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

et al. 2015

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“…Figure 4 The broad band at 3200-2450 cm -1 is attributed to different stretching vibrations of hydrogenbonded OH, NH 2 asymmetric and NH interchain NH··· O=C bonding [27,28].…”

Section: Surface Chemical Composition Characterizationmentioning

confidence: 98%

“…The ATR-FTIR spectra of unmodified and plasmamodified chitosan/PEO with different exposure times at 0.51 plasma power are shown inFigure 4(b). the unmodified chitosan/PEO membrane spectrum presents the appearance of C-H stretching at 1378 cm -1 , C=O stretching correspond to amide at 1655 cm -1 , amide (N-H in plane-deformation coupled with C-N stretching) and amide (C-N stretching coupled with NH in plane-deformation) at 1562 cm -1[27][28][29].…”

mentioning

confidence: 96%

Surface modification of chitosan/PEO nanofibers by air dielectric barrier discharge plasma for acetylcholinesterase immobilization

Dorraki

Safa

Jahanfar

et al. 2015

Applied Surface Science

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“…The CS presents the characteristic band of the carbonyl groups (C=O) at 1658 cm -1 and of free amino groups (-NH 2 ) at 1600 cm -1 (Boonsongrit et al 2008;Yang et al 2004).…”

Section: Structural Characteristicsmentioning

confidence: 99%

Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

et al. 2015

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This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126-214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules.

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Characterization of drug–chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry

Cited by 135 publications

References 26 publications

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

Study on the Effect of Silanization and Improvement in the Tensile Behavior of Graphene-Chitosan-Composite

Surface modification of chitosan/PEO nanofibers by air dielectric barrier discharge plasma for acetylcholinesterase immobilization

Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

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