Characterization of diazepam submicron emulsion interface: Role of oleic acid

Levy, M.; Schütze, Wolfgang; Führer, Claus; Benita, Simon

doi:10.3109/02652049409040440

Cited by 75 publications

(35 citation statements)

References 24 publications

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“…Usually, particle aggregation is less likely to occur for charged particles with high j (. l30l mV) due to electric repulsion [11]. In general, lipid nanoparticles are negatively charged on the surface [12].…”

Section: Zeta Potential (J)mentioning

confidence: 99%

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

199

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Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol w 943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles-solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)-made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol w 812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed. q

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Section: Zeta Potential (J)mentioning

confidence: 99%

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

199

View full text Add to dashboard Cite

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“…A high zeta potential (> 30 mV) can provide an electric repulsion to avoid the aggregation of particles [25]. The incorporation of edelfosine into lipid nanoparticles had no significant influence on the zeta potentials of particles, which was negative in all cases.…”

Section: Particle Size Size Distribution and Zeta Potentialmentioning

confidence: 87%

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: Development and in vitro characterization

Mendoza

Rayo

Mollinedo

et al. 2008

European Journal of Pharmaceutics and Biopharmaceutics

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The ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine, edelfosine ) is the prototype molecule of a promising class of antitumour drugs named alkyl-lysophospholipid analogues (ALPs) or antitumor ether lipids. This drug presents a very important drawback as can be the dose depending haemolysis when administered intravenously. Lipid nanoparticles have been lately proposed for different drug encapsulation as an alternative to other controlled release delivery systems, such as liposomes or polymeric nanoparticles. The aim of this study was to develop a lipid nanoparticulate system that would decrease systemic toxicity as well as improve the therapeutic potential of the drug. Lipids employed were Compritol ® 888 ATO and stearic acid. The nanoparticles were characterized by photon correlation spectroscopy for size and size distribution, and atomic force microscopy (AFM) was used for the determination of morphological properties. By both differential scanning calorimetry (DSC) and X-ray diffractometry, crystalline behaviour of lipids and drug was assessed.The drug encapsulation efficiency and the drug release kinetics under in vitro conditions were measured by HPLC-MS. It was concluded that Compritol ® presents advantages as a matrix material for the manufacture of the nanoparticles and for the controlled release of edelfosine.

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“…Lipid particles are generally negatively charged (Schwarz & Mehnert, 1999) and colloidal system is found to be stable when (4j30j mV) due to electrostatic repulsion (Levy et al, 1994). This is valid only in the case of sole electrostatic stabilization.…”

Section: Particle Size and Zeta Potential () Analysismentioning

confidence: 99%

A vaginal drug delivery model

et al. 2016

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Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and successfully deliver molecules like itraconazole through SLNs. Optimized SLNs with the given composition was selected for further development into mucoadhesive and thermosensitive gel. Stearic acid and Compritol 888 (1:1, w/w ratio) as lipid, a mixture of 3% Poloxomer 188 and 0.5% sodium taurocholate as surfactant and organic to aqueous ratio of 10:50 was taken. Carbopol 934 and Pluronic F 127 were taken for the development of gel. Optimized gel exhibited a desired gelling temperature (35 C); viscosity (0.920 PaS) and appreciable in vitro drug release (62.2% in 20 h). MTT assay did not show any cytotoxic effect of the gel. When evaluated in vivo, it did not exhibit any irritation potential despite appreciable bioadhesion. A remarkable decrease in CFUs was also observed in comparison with control and marketed formulation when evaluated in rat infection model. Thus, the proposed study defines the challenges for developing a suitable formulation system overcoming the delivery barriers of the vaginal site.

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Characterization of diazepam submicron emulsion interface: Role of oleic acid

Cited by 75 publications

References 24 publications

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: Development and in vitro characterization

A vaginal drug delivery model

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