Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

Laiguillon, Marie-Charlotte; Courties, Alice; Houard, Xavier; Auclair, Martine; Sautet, Alain; Capeau, Jacqueline; Fève, Bruno; Bérenbaum, Francis; Sellam, Jérémie

doi:10.1016/j.joca.2015.04.026

Cited by 102 publications

(88 citation statements)

References 46 publications

(30 reference statements)

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“…At the level of expression by chondrocytes mRNA of IL-6 and COX-2, and at the level of production IL-6, and PGE 2 , and NO can influence the level of glucose in culture media. The production of IL-6 by chondrocytes rapidly decreased under addition in culture media Cytochalasin B (the glucose transport inhibitor) [16]. Authors [17], demonstrated effect of glucose levels in culture media on human chondrocytes functional activity.…”

Section: Discussionmentioning

confidence: 99%

Characterization of osteoarthritis in patients with diabetes mellitus type 2

Зонова¹,

Лыков²,

Trifonova³

et al. 2016

Integr Mol Med

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Investigation of the clinical and pathogenesis aspects of osteoarthritis in combinations with diabetes mellitus type 2. Were studied 80 patients with osteoarthritis, 52 of them has a comorbidity disease such as diabetes mellitus type 2. Were investigated the clinical and radiological signs of disease severity, the levels of cytokines, NO, leptin, and CRP in serum, and levels of blood glucose, and levels of glycated hemoglobin, and SSE. Were found significant differences in body weight, data of ESR, features functional status of the joints and the quality of life in patients with osteoarthritis in combination with type 2 diabetes compared with those without the metabolic disturbance. Moreover, in patients with osteoarthritis of comorbidity for T2DM was established elevated level of IL-6, IL-18, NO and leptin in serum. Were determined differences in the features of the clinical symptoms of osteoarthritis in patients with type 2 diabetes based on blood glucose level, and data of glycated hemoglobin. Were obtained some correlations between of the levels of cytokines in the blood serum with the parameters of the functional status of the joints, and with the quality of life in patients with osteoarthritis in combination with type 2 diabetes. Osteoarthritis in combinations with diabetes mellitus type 2 characterized by a more pronounced severity of clinical symptoms, and functions impairment.

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Section: Discussionmentioning

confidence: 99%

Characterization of osteoarthritis in patients with diabetes mellitus type 2

Зонова¹,

Лыков²,

Trifonova³

et al. 2016

Integr Mol Med

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“…Некоторые исследователи склонны рассматривать МетОА только как следствие избыточной нагрузки на опорные суставы вследствие ожирения [19]. Однако многие недавние исследования продемонстрировали, что адипокины, продуцируемые жировой тканью, гипергликемия, инсулинорезистент-ность и дислипидемия могут нарушать метаболизм суставных тканей, впрочем, как и других органов [1,4,8,10,21]. В последние годы также установлены но-вые механизмы, связывающие ОА с метаболическими заболеваниями: прямая взаимосвязь инсулинорези-стентности и синовиального воспаления; роль окис-ленных липопротеидов низкой плотности (ЛПНП) в формировании очагов жирового повреждения кости и поддержания воспаления синовиальной оболочки; потенциальное вовлечение кишечной микрофлоры и наличие циркадных ритмов [14].…”

Section: ë³êàðþ ùî ïðàêòèêóº / To General Practitionerunclassified

Метаболічний Фенотип Остеоартриту: Подвійна Роль Ожиріння

Golovach¹

2022

TRAUMA

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“…T1DM patients showed a decrease in antioxidants defenses and an increase in biomarkers of oxidative damage (Kasznicki et al, 2012). In addition, proinflammatory biomarkers IL-6 and TNF-α are significant predictors of knee OA (Livshits et al, 2009;Kou & Wu, 2014) and OA cartilages from DM patients showed increased responsiveness to IL-1β-induced inflammation via oxidative stress and polyol pathway thus participate in the increased inflammation in OA (Laiguillon et al, 2015). On the other hand, chondroprotective agents such as the antioxidants have been found to promote cartilage repair by stimulating anabolic metabolism of chondrocytes and/or inhibiting catabolic processes found in OA (Altman et al, 1987;Bhattacharya et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Development of a Rat Model of Knee Osteoarthritis by a Combination of Monoiodoacetate and Streptozotocin

et al. 2017

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SUMMARY: Osteoarthritis (OA) caused by ageing joints or as a secondary complication of diabetes is a common health problem. We sought to develop an animal model of OA induced by a combination of the chondrocyte glycolytic inhibitor mono-iodoacetate (MIA) and streptozotocin (STZ), the agent that induces diabetes mellitus. We then hypothesized that the extent of damages to the knee joint induced by this model can be greater than OA induced by either MIA or STZ. Rats were either injected with MIA (model 1) or STZ (model 2) or both agents (model 3). After 8 weeks, harvested tissues from the knee joint of these groups were examined using scanning and transmission electron microscopy. In addition, blood samples were assayed for tumor necrosis factor alpha (TNF-α) and interleukin -6 (IL-6) that are known to be modulated in OA and diabetes. Compared to control group, substantial damages to the articular cartilage of the knee joint were observed in the three models with the severest in model 3. In addition, rats in model 3 showed significant (P<0.0001) increase in TNF-α and IL-6 compared to model 1 and 2. Thus, we have developed a new model of knee OA in rats that mimics a type of OA that is common among elderly people who have both, "ageing" joints and diabetes.

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Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

Cited by 102 publications

References 46 publications

Characterization of osteoarthritis in patients with diabetes mellitus type 2

Characterization of osteoarthritis in patients with diabetes mellitus type 2

Метаболічний Фенотип Остеоартриту: Подвійна Роль Ожиріння

Development of a Rat Model of Knee Osteoarthritis by a Combination of Monoiodoacetate and Streptozotocin

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