Characterization of dental phenotype in patients with cleidocranial dysplasia using longitudinal data

Ha, Sang-Woon; Jung, Yu‐Jin; Bae, Hyun Cheol; Ryoo, Hyun‐Mo; Cho, Il-Sik; Baek, Seung‐Hak

doi:10.2319/092617-647.1

Cited by 7 publications

(7 citation statements)

References 22 publications

(57 reference statements)

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“…According to a previous study, frequently impacted teeth in SFTE2 fail to erupt even after removal of impacted factors 27 (The incidence of failure of tooth eruption after removal of impacted factors was unknown in SFTE 5) (Figure 3).…”

Section: Molecular Classification For Failure Of Tooth Eruptionmentioning

confidence: 96%

“…The incidence of unerupted teeth due to impacted factors seemed to be more common in incisors than in other teeth. 27…”

Section: Unerupted Teethmentioning

confidence: 99%

“…According to a previous study, CCD patients had a reduced spontaneous eruption of unerupted teeth after removal of impacted factors, which was lower in the mandibular canines and premolars than incisors. 27…”

Section: Regional Impacted Factorsmentioning

confidence: 99%

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Genotype‐phenotype analysis of selective failure of tooth eruption—A systematic review

Guo

Duan

2023

Clinical Genetics

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Tooth eruption is an important and unique biological process during craniofacial development. Both the genetic and environmental factors can interfere with this process. Here we aimed to find the failure pattern of tooth eruption among five genetic diseases. Both systematic review and meta‐analysis were used to identify the genotype–phenotype associations of unerupted teeth. The meta‐analysis was based on the characteristics of abnormal tooth eruption in 223 patients with the mutations in PTH1R, RUNX2, COL1A1/2, CLCN7, and FAM20A respectively. We found all the patients presented selective failure of tooth eruption (SFTE). Primary failure of eruption patients with PTH1R mutations showed primary or isolated SFTE1 in the first and second molars (59.3% and 52% respectively). RUNX2 related cleidocranial dysplasia usually had SFTE2 in canines and premolars, while COL1A1/2 related osteogenesis imperfecta mostly caused SFTE3 in the maxillary second molars (22.9%). In CLCN7 related osteopetrosis, the second molars and mandibular first molars were the most affected. While FAM20A related enamel renal syndrome most caused SFTE5 in the second molars (86.2%) and maxillary canines. In conclusion, the SFTE was the common characteristics of most genetic diseases with abnormal isolated or syndromic tooth eruption. The selective pattern of unerupted teeth was gene‐dependent. Here we recommend SFTE to classify those genetic unerupted teeth and guide for precise molecular diagnosis and treatment.

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Section: Molecular Classification For Failure Of Tooth Eruptionmentioning

confidence: 96%

“…The incidence of unerupted teeth due to impacted factors seemed to be more common in incisors than in other teeth. 27…”

Section: Unerupted Teethmentioning

confidence: 99%

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Genotype‐phenotype analysis of selective failure of tooth eruption—A systematic review

Guo

Duan

2023

Clinical Genetics

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“…It is extremely important that it recognizes the clinical signs of CHD, which contributes to early diagnosis, directly influencing treatment and quality of life, returning health and well-being to the individual. al., 2012), cuja funcionalidade é diferenciar as células responsáveis pela formação do tecido ósseo (HA et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Bruxismo Durante O Sono

Nunes¹,

Barros²,

Almeida³

et al. 2022

Contribuições Científicas Em Odontologia: Pesquisas, Práticas E Novos Paradigmas

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“…Although several studies have described panoramic features of CCD, most of them based on only a few cases, and no study has had standardized measurements and quantitative indicators [ 1 , 9 – 11 ]. The aim of this study was to summarize the major maxillofacial features detected on panoramic radiographs from a relatively large retrospective case series of CCD.…”

Section: Introductionmentioning

confidence: 99%

Detection and diagnosis of cleidocranial dysplasia by panoramic radiography: a retrospective study

Shi

Liu

et al. 2022

BMC Oral Health

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Background Cleidocranial dysplasia (CCD) is a rare and underdiagnosed congenital disorder in dentistry. The purpose of this study was to illustrate and quantify the maxillofacial bone abnormalities detected on panoramic radiographs from a relatively large retrospective case series and to provide a series of diagnostic references for dentists to indicate the presence of disease and help in making an early and accurate diagnosis. Methods The dental panoramic radiographs of thirty CCD patients aged 11 to 45 years (18 males and 12 females) were examined retrospectively. The dentition states, including supernumerary teeth and impacted teeth, were recorded. Twelve quantified measurements were adopted to determine the abnormalities of maxillofacial bones, including the degree of the zygomatic arch downward bend, bicondylar breadth, ramal height, mandibular height, mandibular aspect ratio, mandibular body height, condylar height, coronoid height, distance between the coronoid process and the condyle, bigonial width, gonial angle and best-fit gonial circle diameter. The Wilcoxon rank-sum test was used to compare the findings of the CCD patients with those of their matched controls (n = 300). Results Supernumerary teeth were detected in 27 patients (90.0%), and all 30 patients presented impacted teeth. Compared to the matched controls, the CCD patients had a significantly larger degree of zygomatic arch downward bend (ZAD), a larger diameter of the best-fit gonial circle (BGC), and a shorter distance between the coronoid process and the condyle (DCC) in panoramic radiographs (P < 0.001). According to the reference cutoff values established from the 5th or 95th percentile of the measurements in the control group, ZAD higher than 6.90 mm, DDC less than 22.37 mm and BGC higher than 52.41 mm were significantly associated with the CCD features identified. Other panoramic measurements were not significantly different between the two groups. Conclusions Panoramic radiographs had great value in the diagnosis of CCD. In this study, we identified some dental and maxillofacial features on panoramic radiographs from a relatively large retrospective case series of CCD. A series of reliable quantitative indicators were provided for dentists that can indicate the presence of disease and improve the diagnostic specificity.

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Characterization of dental phenotype in patients with cleidocranial dysplasia using longitudinal data

Abstract: The emergence time and development position of ST and the root development of IPT should be considered to determine the timing for the removal of ST and forced eruption of IPT.

Cited by 7 publications

References 22 publications

Genotype‐phenotype analysis of selective failure of tooth eruption—A systematic review

Genotype‐phenotype analysis of selective failure of tooth eruption—A systematic review

Bruxismo Durante O Sono

Detection and diagnosis of cleidocranial dysplasia by panoramic radiography: a retrospective study

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