Characterization of Dengue Virus Type 2: New Insights on the 2010 Brazilian Epidemic

Romano, Camila Malta; Matos, Andréia Manso de; Araújo, Evaldo Stanislau Affonso de; Villas-Boas, Lucy Santos; Silva, Wanessa Cardoso da; Oliveira, Olímpia M. N. P. F.; Carvalho, Karina I.; Souza, Ana Carolina Mamana de; Rodrigues, Célia Luiza de Lima; Levi, José Eduardo; Kallas, Esper G.; Pannuti, Cláudio Sérgio

doi:10.1371/journal.pone.0011811

Cited by 40 publications

(46 citation statements)

References 28 publications

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“…An analysis of the envelope (E) gene of isolates from Rio de Janeiro and São Paulo collected during 2007–2008 and 2010 revealed that at least two lineages of the American-Asian genotype of DENV-2 have circulated in Brazil [20]–[22]. In addition, the virus that circulated in São Paulo in 2010 was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008 [21].…”

Section: Introductionmentioning

confidence: 99%

Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauí, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil

et al. 2014

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Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described.

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Section: Introductionmentioning

confidence: 99%

Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauí, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil

et al. 2014

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“…American/Asian genotype DENV-2 strains isolated during a São Paulo state outbreak (2010) were closely related to strains circulating during the 2007–8 epidemic in Rio de Janeiro and Ribeirão Preto, but distinct from those of earlier DENV-2 epidemics in Brazil. No phylogenetic clustering by clinical presentation was observed [35]. …”

Section: Resultsmentioning

confidence: 99%

Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends

et al. 2017

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Dengue, the predominant arthropod-borne viral disease affecting humans, is caused by one of four distinct serotypes (DENV-1, -2, -3 or -4). A literature analysis and review was undertaken to describe the molecular epidemiological trends in dengue disease and the knowledge generated in specific molecular topics in Latin America, including the Caribbean islands, from 2000 to 2013 in the context of regional trends in order to identify gaps in molecular epidemiological knowledge and future research needs. Searches of literature published between 1 January 2000 and 30 November 2013 were conducted using specific search strategies for each electronic database that was reviewed. A total of 396 relevant citations were identified, 57 of which fulfilled the inclusion criteria. All four dengue virus serotypes were present and co-circulated in many countries over the review period (with the predominance of individual serotypes varying by country and year). The number of countries in which more than one serotype circulated steadily increased during the period under review. Molecular epidemiology data were found for Argentina, Bolivia, Brazil, the Caribbean region, Colombia, Ecuador, Mexico and Central America, Paraguay, Peru and Venezuela. Distinct lineages with different dynamics were found in each country, with co-existence, extinction and replacement of lineages occurring over the review period. Despite some gaps in the literature limiting the possibility for comparison, our review has described the molecular epidemiological trends of dengue infection. However, several gaps in molecular epidemiological information across Latin America and the Caribbean were identified that provide avenues for future research; in particular, sequence determination of the dengue virus genome is important for more precise phylogenetic classification and correlation with clinical outcome and disease severity.

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“…Our study reports that the Panamanian DENV-2 strain, circulating during 2011 outbreak, belongs to Asian/American genotype (AS/AM). The introduction of this genotype has been linked with outbreaks with high mortality rates 41,45,46 in Peru 47 , Nicaragua 27 and Brasil 48 . Our phylogenetic analysis clustered Panama 2011 DENV-2 strains in clade 2 sub-clade 2b.I using previous classification of DENV-2 AS/AM circulating in Central America 26 , closely related with strains from Mexico 2011 and Guatemala 2009.…”

Section: Discussionmentioning

confidence: 99%

The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic

et al. 2018

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The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and −3 were predominant. Herein, we describe the 2011 Panama outbreak and genetically characterize the Panamanian DENV-2 strains, which were associated with severe dengue disease in Panama. Our results suggest that the DENV-2 isolates from this outbreak belonged to the AS/AM genotype sub-clade 2BI and were genetically close to viruses described in the outbreaks in Nicaragua, Honduras, Guatemala and Mexico from 2006–2011. Sub-clade 2BI has previously been associated with severe disease in Nicaragua during outbreaks from 2005–2007.

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Characterization of Dengue Virus Type 2: New Insights on the 2010 Brazilian Epidemic

Cited by 40 publications

References 28 publications

Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauí, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil

Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauí, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil

Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends

The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic

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