Characterization of Cyclodepsipeptides from the Mycelium of <i>Isaria Japonica</i> from Vietnam

Tuấn, Nguyễn Ngọc; Ngân, Nguyễn Thị Thanh; Kuo, Ping Chung; Hung, Hsin Yi; Lan, Tran Ngoc; Thanh, Nguyen Tan; Xuan, Dao Thi Thanh; Thăng, Trân Đình; Wu, Tian Shung

doi:10.1177/1934578x1701200317

Cited by 1 publication

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References 7 publications

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“…Beauverolides (also known as beauveriolides or beauverolides) are peptidic secondary metabolites that are abundantly synthetized by entomopathogenic fungi, including Beauveria bassiana (Elsworth & Grove, 1977;Isogai et al, 1978), Beauveria brongniartii (syn. B. tenella; Jegorov et al, 2004), B. vermicoria (Kadlec et al, 1994), Isaria fumosorosea, Isaria japonica (Tuan et al, 2017), and Cordyceps militaris (Chen et al, 2018;Nakaya et al, 2012). Isaria spp.…”

Section: Introductionmentioning

confidence: 99%

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

Heneberg

Jegorov

Šimek

2020

CyTA - Journal of Food

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Beauverolides are hydrophobic cyclodepsipeptides that inhibit sterol O-acyltransferases and calmodulin, thereby reducing senile plaques in Alzheimer's disease and preventing foam cell formation in atherosclerosis. Other sterol O-acyltransferase inhibitors suffer from low bioavailability, and evidence of the distribution of beauverolides in bodily fluids is lacking. We aimed to determine the optimal formulation of beauverolides for administration to experimental animals and to determine if the orally administered beauverolides could cross the gastrointestinal barrier and be secreted in urine. We found that beauverolides formed gels in aqueous solutions and we developed a formula for their peroral administration. Administration of the beauverolide gel pellets to experimental mice revealed that beauverolides cross the gastrointestinal barrier, circulate untouched in the blood, and are excreted in the urine. Using liquid chromatography-mass spectrometry analyses, we show that the administered beauverolides circulate in mouse blood and are excreted from the body 24 h after their administration.La administración peroral de beauverólidos permite su transporte a la sangre periférica y la orina RESUMEN Los beauverólidos son ciclodepsipéptidos hidrofóbicos que inhiben las O-actiltransferasas de esterol y la calmodulina, reduciendo las placas seniles en la enfermedad de Alzheimer y previniendo la formación de células espumosas en la aterosclerosis. Otros inhibidores de la O-aciltransferasa esterólica tienen baja biodisponibilidad y no existen pruebas sobre la distribución de los beauverólidos en los fluidos corporales. El presente estudio se propuso determinar la formulación óptima de los beauverólidos para su administración a animales de experimentación, de modo de establecer si administrados por vía oral podían atravesar la barrera gastrointestinal y ser secretados en la orina. En este sentido se constató que los beauverólidos forman geles en soluciones acuosas, por lo que se desarrolló una fórmula para su administración peroral. La administración de gránulos de gel de beauverólido a ratones experimentales confirmó que los mismos cruzan la barrera gastrointestinal, circulan sin ser modificados en la sangre y son excretados en la orina. Mediante análisis de cromatografía líquida y espectrometría de masas, demostramos que los beauverólidos administrados circulan en la sangre de los ratones y 24 horas después de su administración son excretados del cuerpo.

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Section: Introductionmentioning

confidence: 99%

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

Heneberg

Jegorov

Šimek

2020

CyTA - Journal of Food

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Characterization of Cyclodepsipeptides from the Mycelium of Isaria Japonica from Vietnam

Abstract: A new cyclodepsipeptide, isarin (1), was isolated from the insect pathogenic fungus Isaria japonica Yasuda, together with one known compound, beauveriolide I (2). The structure of this new compound was characterized using a combination of spectroscopic and spectrometric analyses.

Cited by 1 publication

References 7 publications

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

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