Characterization of comorbidity heterogeneity among 13,667 patients with hidradenitis suppurativa

Hua, Vivian; Kilgour, James M.; Cho, Hyunje G.; Li, Shufeng; Sarin, Kavita Y.

doi:10.1172/jci.insight.151872

Cited by 14 publications

(10 citation statements)

References 51 publications

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“…Acne was chosen as a common comorbidity of HS (Hua et al, 2021), which has been associated with plasma cell infiltration into the skin (Carlavan et al, 2018), while AD is an unrelated inflammatory skin disease that nevertheless accompanies lymphadenopathy (Spergel and Paller, 2003) and changes in the B cell compartment (Czarnowicki et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

Macchiarella¹,

Cornacchione²,

Cojean³

et al. 2023

Journal of Investigative Dermatology

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Section: Resultsmentioning

confidence: 99%

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

Macchiarella¹,

Cornacchione²,

Cojean³

et al. 2023

Journal of Investigative Dermatology

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“…After the screening process excluding ineligible studies, we included 10 observational studies for critical appraisal. This includes 3 cohort studies ( 15 – 17 ), 1 case-control study ( 11 ) and 6 cross-sectional studies ( 10 , 12 , 18 – 21 ). Within the included studies, only one of them were originated from Asia, whereas most of the studies were originated from Europe (4out of 10 studies) and the United States (5 out of 10 studies).…”

Section: Resultsmentioning

confidence: 99%

“…The present study demonstrated that patients with HS have a 2-3 times the risk of being affected with psoriasis. Among the extracted articles, the strongest correlation was observed in a study of 13,667 HS patients where there is three times the risk of developing psoriasis compared to controls ( 18 ). Moreover, in the stratification of gender, both male and female patients with HS presented the trend of higher psoriasis risk.…”

Section: Discussionmentioning

confidence: 99%

Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis

et al. 2022

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BackgroundHidradenitis suppurativa were associated with comorbidities in various organ systems. Inflammatory dermatological diseases such as pyoderma gangrenosum were reported to be associated with hidradenitis suppurativa. Nevertheless, as for the association between hidradenitis suppurativa and psoriasis, evidences were insufficient. In many studies, the association between psoriasis and hidradenitis suppurativa has been reported. However, some evidence seems to be controversial. The purpose of the systematic review and meta-analysis was to assess whether there was significant association between HS and psoriasis.MethodsOn June 01, 2022, we appraised 2,795 articles from databases including PubMed, Web of Science and Embase. Search syntaxes were based on ‘hidradenitis suppurativa’ or ‘acne inversa’ with “psoriasis”, “comorbidities” or ‘epidemiology’. Synonyms were determined based on MeSH terms and Emtree. Observational results that evaluated the odds ratio for people with hidradenitis suppurativa who had psoriasis were extracted for qualitative synthesis.ResultsAfter the selection process of the initial 2,795 studies, ten observational studies, including 3 cohort studies, 1 case-control study, and 6 cross-sectional studies, were extracted for critical appraisal. Based on the integration of 7 studies (with more than 560,000 participants included), people with hidradenitis suppurativa had a higher risk of having psoriasis, with a 2.67-fold risk (95% CI, 1.84, 3.87). The association remained in the sensitivity analyses utilizing strict adjustment models. In the analysis that only included studies with a similar study design and adjustments in obesity-related factors, the risk of people with hidradenitis suppurativa having psoriasis was 3.24 (95% CI, 2.27, 4.62). In male patients with HS, the risk of having psoriasis was 4.30-fold higher than male patients without HS (95% CI, 2.37, 7.78). Likewise, in an analysis including 3 cross-sectional studies, the risk of female HS patients having psoriasis was 3.94-fold higher than female HS-free patients (95% CI, 2.34, 6.63).ConclusionsThe co-occurrence of hidradenitis suppurativa and psoriasis can greatly increase the burden of the disease. Psoriasis could be one of the critical comorbidities of hidradenitis suppurativa and should be recommended for future screening and follow up. The association between the two diseases should be kept in mind in managing hidradenitis suppurativa patients. More prospective studies are needed to establish the true magnitude of the association between psoriasis and hidradenitis suppurativa.

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“…In this systematic review, five main contributors to HS pathophysiology were addressed: genetics, immunity, microbiome, and endocrinology, together with the identification of risk factors/comorbidities. Mutations in genes encoding gamma-secretase, an intramembrane protease complex, are among the most commonly dities associated with HS were acne, polycystic ovary syndrome, pilonidal sinus, metabolic syndrome, autoimmune disease, and mental health disorders 110 .…”

Section: Discussionmentioning

confidence: 99%

“…Different comorbidities have been linked to HS and could complicate the course of the disease 85,86,96,97,[105][106][107][108][109][110][111] . Comprehensive analysis showed that the main comorbi-…”

Section: (Continues)mentioning

confidence: 99%

Pathophysiology of hidradenitis suppurativa: a systematic review of the literature

Mendes‐Bastos¹,

Andrade²,

Cabete³

et al. 2022

PJDV

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Hidradenitis suppurative (HS) is a multifactorial, recurrent, chronic inflammatory disease with a significant impact on patient's quality of life. The etiopathogenesis of this complex condition is not fully understood. In this systematic review, we aimed to address and clarify the role of genetics, immunity, endocrinology, and skin microbiome together with risk factors in HS etiopathogenesis. A systematic review, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was performed using PubMed ® and Web of Science TM databases on December 3rd, 2021, using patient/population, intervention, comparison and outcomes (PICO) criteria, limited to the last 10 years and English. Reports were analyzed by two independent reviewers. A total of 123 reports were included and divided into five sections: genetics, immunity, endocrinology, microbiome, and risk factors. Regarding genetics, up to 30-40% of patients have a positive family history of HS but only a small subset of these harbor genetic variants in components of the gamma-secretase complex. In fact, in more than 90% of HS patients, the genetic features contributing to disease development remain largely unknown. The immune response is also crucial for HS; it is characterized by antimicrobial peptide and proinflammatory cytokine dysregulation, namely interleukin (IL)-IL-23, IL-12, and Th17 immune response. This immune response in local and, consequently, systemic inflammation is amplified in patients with metabolic syndrome. The relationship between metabolic syndrome and HS is clear, and patients with metabolic syndrome have a higher risk of developing HS. The most recent evidence also associates skin microbiota dysbiosis with HS pathogenesis, contributing to local and systemic inflammation. Besides these intrinsic factors, the role of lifestyle in the development of HS is well accepted. Tobacco smoking and obesity are the main risk factors identified as contributing to HS pathogenesis. Chronic inflammation characterizes HS, a debilitating condition with a complex and multifactorial etiopathogenesis. The current model integrates genetics, immunity, endocrinology, and skin microbiome. Notwithstanding, efforts should be made to improve our comprehension of HS etiopathogenesis, hopefully leading to the development of more effective treatments.

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Characterization of comorbidity heterogeneity among 13,667 patients with hidradenitis suppurativa

Cited by 14 publications

References 51 publications

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis

Pathophysiology of hidradenitis suppurativa: a systematic review of the literature

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