Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19
Candice N. Baker,
Debra Duso,
Nagarama Kothapalli
et al.
Abstract:Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range beyond primates, and a limited range of other mammals, to mice, affording the opportunity to exploit genetically diverse mouse panels to model the broad range of responses to infection in patient populations. Here we surveyed responses to VOC infection in genetically diverse Collaborative Cross (CC) founder strains. Infection of wild-derived CC founder strains produced a broad range of viral burden, disease susceptibility and… Show more
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