Characterization of clinical features and outcome for human-to-human transmitted severe fever with thrombocytopenia syndrome

Jia, Bin; Wu, Weihua; Huang, Rui; Wang, Guiyang; Song, Peixin; Yang, Li; Liu, Yong; Xiong, Ye; Yan, Xiaomin; Hao, Yingying; Xia, Juan; Zhang, Zhaoping; Chen, Yuxin; Wu, Chao

doi:10.1080/23744235.2018.1449962

Cited by 19 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Veterinary doctors and co-workers have been infected with SFTSV through close contact with sick cats which were virologically confirmed to be infected with SFTSV. This indicates that there is a high risk of being infected with SFTSV from sick animals through direct contact, as is the case in human-to-human SFTSV infections [ 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Tsuru

Suzuki

Murakami

et al. 2021

Viruses

View full text Add to dashboard Cite

A woman in her fifties showed symptoms of fever, loss of appetite, vomiting, and general fatigue 2 days after she was bitten by a sick cat, which had later died, in Yamaguchi prefecture, western Japan, in June 2016. She subsequently died of multiorgan failure, and an autopsy was performed to determine the cause of death. However, the etiological pathogens were not quickly identified. The pathological features of the patient were retrospectively re-examined, and the pathology of the regional lymph node at the site of the cat bite was found to show necrotizing lymphadenitis with hemophagocytosis. The pathological features were noted to be similar to those of patients reported to have severe fever with thrombocytopenia syndrome (SFTS). Therefore, the lymph node section was retrospectively tested immunohistochemically, revealing the presence of the SFTS virus (SFTSV) antigen. The sick cat showed similar symptoms and laboratory findings similar to those shown in human SFTS cases. The patient had no history of tick bites, and did not have skin lesions suggestive of these. She had not undertaken any outdoor activities. It is highly possible that the patient was infected with SFTSV through the sick cat’s bite. If a patient gets sick in an SFTS-endemic region after being bitten by a cat, SFTS should be considered in the differential diagnosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Tsuru

Suzuki

Murakami

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…Therefore, precautions regarding direct contact and droplet transmission should be considered in both family members and HCWs [15]. Fortunately, most secondary patients show mild clinical presentations and good prognoses compared with the primary patient, suggesting that the transmission route makes a difference in SFTS progression [6].…”

Section: Discussionmentioning

confidence: 99%

“…SFTS is largely observed among farmers involved in agricultural activities as well as forest workers, and the majority of cases are reported in people of 50 years of age or older [2, 3]. Although SFTS is tick-borne disease, some studies have reported that SFTSV can be transmitted from person to person [4–6]. As this transmission is mostly driven by close contact to the index case, SFTS has been reported in healthcare workers (HCWs) [7], and asymptomatic infections have been noted in family members with close contact [4, 5].…”

mentioning

confidence: 99%

Occupational Risk of Severe Fever With Thrombocytopenia Syndrome in Healthcare Workers

Yoo

Choi

Kim

et al. 2019

Open Forum Infectious Diseases

View full text Add to dashboard Cite

We identified a healthcare-associated infection of severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV), transmitted through direct blood contact with an index case. Following further epidemiological and clinical investigations, we identified SFTSV seropositivity in 2 healthcare workers and 2 family members, who were positive for anti-SFTSV immunoglobin G. It is important to prevent SFTSV transmission by early diagnosis of SFTS and universal precautions.

show abstract

“…For people living in cities, they are less likely to be infected with SFTSV. And even human-to-human transmission, the greatest chance of occurrence was only the population who contact its blood, such as nurses or family members [53]. In addition, secondary SFTS infection leads to milder clinical manifestations compared with primary SFTS.…”

Section: The Effect Of Taking Interventionsmentioning

confidence: 99%

Modelling the Transmission Dynamics of Severe Fever With Thrombocytopenia Syndrome in Jiangsu Province

Zhang

Cheng

Deng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is regionally distributed in Asia with high fatality. Constructing the transmissibility model of SFTS could help provide clues for the intervention of disease control and fill the gap in the research of the SFTS model.Methods: Based on the Susceptible–Exposed–Infectious–Symptomatic–Recovered (SEIAR) model and combined with the epidemiological characteristics of SFTS in Jiangsu Province. An SFTS transmission dynamics model was built to evaluate the effect through cutting off the different transmission routes and taking different interventions, to offer clues for disease prevention and control, and filled the gap in research of the SFTS model. Results: For the transmission model of SFTS, the fitting effect of case data and model is great. Meanwhile, cutting off the transmission routes of the environment have the greatest effect on the prevention and control of SFTS, but isolation and shorten the course of the disease did not gain more effect.Conclusions: This study is determined that cutting off the transmission routes from the environment to humans had the greatest effect on SFTS prevention and control.

show abstract

Characterization of clinical features and outcome for human-to-human transmitted severe fever with thrombocytopenia syndrome

Abstract: Secondary SFTS acquired through human-to-human transmission leads to milder clinical representations and superior prognoses compared to primary SFTS, suggesting that the transmission route makes a difference in disease progression and clinical outcome of SFTS disease.

Cited by 19 publications

References 23 publications

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Occupational Risk of Severe Fever With Thrombocytopenia Syndrome in Healthcare Workers

Modelling the Transmission Dynamics of Severe Fever With Thrombocytopenia Syndrome in Jiangsu Province

Contact Info

Product

Resources

About