Characterization of chitosan nanoparticles as an edible coating material

Rosyada, Amrina; Sunarharum, Wenny Bekti; Waziiroh, Elok

doi:10.1088/1755-1315/230/1/012043

Cited by 19 publications

(12 citation statements)

References 7 publications

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“…The PDI of a polymer is measured by dividing the weight average by number average molecular weight and it ranges from 0 to 1 [ 61 ]. The closer to 0 a PDI value, the more homogenous the nanoparticle solution, while values above 0.5 indicate that a NP solution is heterogeneous [ 62 ]. The PDI of the chitosan-based NPs presented in Table 1 ranges between 0.009 [ 39 ] and 0.48 [ 46 ].…”

Section: Physico-chemical Aspects Of the Protein Corona Formationmentioning

confidence: 99%

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

et al. 2020

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Chitosan is a polymer that is extensively used to prepare nanoparticles (NPs) with tailored properties for applications in many fields of human activities. Among them, targeted drug delivery, especially when cancer therapy is the main interest, is a major application of chitosan-based NPs. Due to its positive charges, chitosan is used to produce the core of the NPs or to cover NPs made from other types of polymers, both strategies aiming to protect the carried drug until NPs reach the target sites and to facilitate the uptake and drug delivery into these cells. A major challenge in the design of these chitosan-based NPs is the formation of a protein corona (PC) upon contact with biological fluids. The composition of the PC can, to some extent, be modulated depending on the size, shape, electrical charge and hydrophobic / hydrophilic characteristics of the NPs. According to the composition of the biological fluids that have to be crossed during the journey of the drug-loaded NPs towards the target cells, the surface of these particles can be changed by covering their core with various types of polymers or with functionalized polymers carrying some special molecules, that will preferentially adsorb some proteins in their PC. The PC’s composition may change by continuous processes of adsorption and desorption, depending on the affinity of these proteins for the chemical structure of the surface of NPs. Beside these, in designing the targeted drug delivery NPs one can take into account their toxicity, initiation of an immune response, participation (enhancement or inhibition) in certain metabolic pathways or chemical processes like reactive oxygen species, type of endocytosis of target cells, and many others. There are cases in which these processes seem to require antagonistic properties of nanoparticles. Products that show good behavior in cell cultures may lead to poor in vivo results, when the composition of the formed PC is totally different. This paper reviews the physico-chemical properties, cellular uptake and drug delivery applications of chitosan-based nanoparticles, specifying the factors that contribute to the success of the targeted drug delivery. Furthermore, we highlight the role of the protein corona formed around the NP in its intercellular fate.

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Section: Physico-chemical Aspects Of the Protein Corona Formationmentioning

confidence: 99%

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

et al. 2020

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“…The PDI describes the distribution of particles with a range between 0 and 1 [ 50 ]. It has been stated that a PDI value > 0.5 shows the polydisperse distribution, which is why it is desirable to maintain the PDI as low as possible [ 19 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, due to interactions between CS and STPP, the bands of amide I and amide II dramatically shifted to 1638 and 1548 cm −1 and the P=O groups, which were also observed in the absorption bands at wavenumbers 1049 and 1019 cm −1 . It seems that increasing the peak intensity of the angular deformation of the CH 2 group at 1407 cm −1 can be attributed to rising the polarization of the carbonyl group upon its interaction [ 50 , 53 , 54 ]. The formation of this group confirmed the interaction between phosphate groups of STPP and CS by ionic bonds.…”

Section: Resultsmentioning

confidence: 99%

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Physicochemical, Thermal, and Morphological Properties of Chitosan Nanoparticles Produced by Ionic Gelation

Alehosseini

Tabarestani

Kharazmi

et al. 2022

Foods

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Chitosan nanoparticles (CSNPs) can be widely used in the food, pharmaceutical, and cosmetic sectors due to their high performance, unique properties, and high surface area. In this research, CSNPs were produced by the ionic gelation method and using sodium tripolyphosphate (STPP) as an appropriate technique compared to the conventional methods. To evaluate the effects of various factors on the size, zeta potential (ZP), and optimal synthesis conditions, different concentrations of CS (1, 3, and 5 mg/mL), STPP (0.5, 0.75, and 1 mg/mL), and CS to STPP ratio (1:1, 3:1, and 5:1) were applied and optimized using the response surface methodology. The size of CSNPs was increased by using higher concentrations of CS, STPP, and CS/STPP ratios. The value of ZP was determined positive and it increased with increasing CS concentrations and CS/STPP ratios. ATR-FTIR spectra revealed interactions between CS and STPP. The DSC thermogram of CSNPs showed a double sharp endothermic peak at about 74.5 °C (ΔH = 122.00 J/g); further, the TGA thermograms indicated the total weight loss of STPP, CS, and CSNPs as nearly 3.30%, 63.60%, and 52.00%, respectively. The XRD data also revealed a greater chain alignment in the CSNPs. Optimized, the CSNPs can be used as promising carriers for bioactive compounds where they also act as efficient stabilizers in Pickering emulsions.

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“…Chitosan which is broken into smaller sizes will stick and form algumations, so a surfactant is needed to spread the chitosan so it doesn't stick and agglomerate, tween 80 can be used as a surfactant in the nanochitosan modification process. The formed nanochitosan still has a unique functional group from chitosan itself and a phosphate group appears because the process has cross-linked between sodium tripolyphosphate through ionic bonds which indicates that nanoparticles have been formed Rosyada et al [10]. The modification mechanism of chitosan with ionic gelation method can be seen in Fig.…”

Section: Manufacture Of Nanochitosanmentioning

confidence: 97%

Study of Nanochitosan (Definition, Manufacture, Analysis of Characteristics and Utilization): Review

Sektiaji¹,

Rochima²,

Pratama³

et al. 2022

AJFAR

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Nanochitosan is a nanoparticle of chitosan with a size between 100-400 nm. Nanochitosan has a higher antibacterial ability than ordinary chitosan. The manufacture of chitosan into nanochitosan can be done by ionic gelation method, namely the complexation of polyelectrolyte between positively charged of chitosan and negatively charged of sodium tripolyphosphate. The morphology of nanochitosan is in the form of a whole sphere and has typical chitosan functional groups such as amine, hydroxyl and carboxyl groups. Utilization of Nanochitosan can be used as a natural preservative because it has antibacterial properties in the form of edible coating. Fish filets coated with nanochitosan edible coating can extend the shelf life and maintain freshness which can be seen from the physiochemical characteristics.

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Characterization of chitosan nanoparticles as an edible coating material

Cited by 19 publications

References 7 publications

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

Physicochemical, Thermal, and Morphological Properties of Chitosan Nanoparticles Produced by Ionic Gelation

Study of Nanochitosan (Definition, Manufacture, Analysis of Characteristics and Utilization): Review

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