Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator

Chen, Jyh‐Ping; Yang, Pei-Chin; Ma, Yunn‐Hwa; Wu, Tony

doi:10.1016/j.carbpol.2010.11.052

Cited by 150 publications

(80 citation statements)

References 37 publications

(34 reference statements)

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“…Therefore, for drug delivery applications, MNPs must be precoated with substances that assure their stability, biodegradability, and nontoxicity in the physiological medium to achieve combined properties of high magnetic saturation, biocompatibility, and interactive functions on the surface. The polymer coating not only leads to the creation of more hydrophilic nanostructures, but also provides a variety of surface functional groups to bind drug molecules, inhibit aggregation, and increase stability [146][147][148][149].…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

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Section: Targeted Drug Deliverymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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“…Chen et al [49] utilized the normal method by first preparing Fe 3 O 4 magnetic nanoparticles followed by suspension in a chitosan solution that was vigorously stirred 32 Chitosan-g-NIPA-co-DMAA: Chitosan-g-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide). 30 n-HA: Nano-hydroxyapatite.…”

Section: Biomedical Applications That Utilize Chitinmentioning

confidence: 99%

The Impact of Nanotechnology on Chitin and Chitosan Biomaterials Research

Khor

2014

Chitin

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“…The in vitro studies have shown that tPA encapsulated in liposomes [58,59] or in poly(lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan was more efficient in dissolving the blood clots than tPA in solution [60,61]. For magnetically targeted detection of thrombi and dynamic in vivo monitoring of the thrombolytic drug efficiency using MRI, the SPION conjugated with tPA have been synthesized [62,63]. To take advantage from the biochemical targeting, the surfaces of tPA containing nanoparticles were modified with cyclic arginineÀglycineÀaspartic acid (RGD) tripeptide.…”

Section: Thrombosismentioning

confidence: 99%