Characterization of chitosan acetate as a binder for sustained release tablets

Nunthanid, Jurairat; Laungtana-Anan, M.; Sriamornsak, Pornsak; Limmatvapirat, Sontaya; Puttipipatkhachorn, Satit; Lim, Lee Yong; Khor, Eugene

doi:10.1016/j.jconrel.2004.06.008

Cited by 143 publications

(66 citation statements)

References 30 publications

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“…7, the spray-dried chitosan acetate also showed an additional endothermic peak in the temperature range of 150-200°C. According to the literature, endothermic peaks of chitosan acetate are related to the weight loss of the salt (10). The fact that the values for ΔH increased with the moisture content of the samples may indicate that the chitosan salts studied here differ from each other with respect to their water-polymer interaction and their water holding capacity.…”

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 70%

“…The effects of temperature on physicochemical properties of the spray-dried powders were studied by setting the inlet/ outlet temperatures at 120/80°C, 140/90°C, and 160/100°C, respectively. In this study, the inlet temperature levels studied in a spray-drying process were selected based on earlier related studies on spray-dried chitosan salts (10,19,21).…”

Section: Spray Drying Of Chitosan Acid Saltsmentioning

confidence: 99%

“…There are a number of recent examples in the literature on applications of chitosan salts in pharmaceutical drug delivery systems. Chitosan acid salts such as glutamate, aspartate, hydrochloride, and acetate were used for colon-specific drug delivery and to enhance the delivery of therapeutic peptide across intestinal epithelia (8)(9)(10)(11)(12). Chitosan and some chitosan acid salts were reported to be carriers for transfection of DNA (13).…”

Section: Introductionmentioning

confidence: 99%

“…Spray drying can be regarded as the only process that directly converts a liquid into a dry solid in a single step, and consequently, it is especially well suited for, e.g., heat-sensitive products. To date, several research articles have been published on microspheres prepared by spray-drying solution of chitosan using organic acids as solvents (10,12,(19)(20)(21)(22). A chitosan derivative as an acetate salt was successfully prepared by using a spray-drying technique and characterized as a binder for sustained release tablets (10).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

et al. 2011

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Abstract. The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS 13 C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state 13 C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm −1 were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm −1 , respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.

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Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 70%

Section: Spray Drying Of Chitosan Acid Saltsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

et al. 2011

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“…Chitosan has been extensively examined in the pharmaceutical industry for its potential in the development of controlled release of drug delivery due to its excellent biocompatibility, biodegradability, bioactivity and nontoxicity [14]. Various sustained release drug carriers have been made from chitosan such as microparticles [15], tablets [16], gel [17] and beads [18]. Chitosan microspheres have been widely investigated for use as controlled release delivery systems for hormones [19], vitamins [20], proteins [21] and enzymes [22].…”

Section: Introductionmentioning

confidence: 99%