Characterization of children with recurrent eczema herpeticum and response to treatment with interferon‐gamma

Darji, Kavita; Frisch, Stephanie; Boakye, Eric Adjei; Siegfried, Elaine C.

doi:10.1111/pde.13301

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…Though a study conducted by Darji K et al concluded that gamma interferon have no role in improving EH or preventing its' relapse. 9 Till now no studies have demonstrated the evaluation of Acyclovir therapy in pediatric burn patients with EH. Although, its use has been described in children hospitalized with EH.…”

Section: Discussionmentioning

confidence: 99%

Eczema Herpeticum in children with burns

et al. 2021

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Background & Objective: Eczema herpeticum (EH) is a disseminated viral infection occurring in pre-existing skin conditions and burns. The objective of this study was to determine the frequency, treatment, and outcome of EH in pediatric burn patients. Methods: This retrospective study was conducted in the pediatric surgery department, King Edward Medical University/ Mayo Hospital, Lahore, from October 2015 to July 2018 after ethical approval. All pediatric burn patients diagnosed with EH and not sensitive to Acyclovir or suffering from chemical burns were enrolled in the study. Diagnosis was confirmed by presence of umbilicated lesions in burnt area and a positive Tzanck smear. Intravenous acyclovir and supportive treatment was started. Mortality, development of contractures, length of hospital stay/ time for wound healing, re-activation of EH was calculated. Results: Out of 3958 admitted pediatric burn patients, 94(2.4%) developed EH. Girls were 58(61.7%) and boys were 36(38.3%). Mean age was 5.16 ±2.88 years. Scald burn was in 43(45.7%) patients, flame burn in 48(51.1%) patients, and electric flash burn in 3(3.2%) patients. Mean TBSA was 21.74±10.38%. Vesicular eruptions settled in 92 (97.9%) patients after treatment with acyclovir. Mean duration of treatment was 19.89±8.9 days and hospital stay was 29.84±16.98 days. Twenty three patients (24.5%) developed contractures and two patients (2.1%) developed disseminated EH and expired. Six (6.4%) patients had re-activation of EH. Conclusion: EH occurred in 2.4% of admitted pediatric burn patients. Intravenous acyclovir was successful in 97.9% of the patients, although 2.1% developed disseminated EH and expired. Re-activation occurred in 6.4% of the cases and was associated with prolonged hospital stay. doi: https://doi.org/10.12669/pjms.37.2.3642 How to cite this:Naumeri F, Rijal S, Rashid AR, Ahmad HM. Eczema Herpeticum in children with burns. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3642 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Eczema Herpeticum in children with burns

et al. 2021

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“…Prompt treatment with systematic antiviral medication can prevent or lessen complications [5]. Acyclovir is the gold standard therapy, although immunomodulatory treatments have also been considered with controversial results [6]. According to Aronson et al [7], antibiotics do not really affect the prognosis of this entity, although the prophylactic use of antibiotics could prevent certain secondary bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

Herpeticum-like rash in a child with atopic dermatitis: early clinical suspicion is valuable

et al. 2018

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Dermatological conditions may be associated with serious underlying medical conditions which require urgent treatment. We describe the case of a 6-year-old boy with erythematous vesicles with erosion and crusting on face, cheeks, and forehead. Due to the medical history of atopic dermatitis, eczema herpeticum was suspected and appropriate treatment was immediately initiated. This resulted in significant improvement of skin lesions.

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“…In children, following fever and lymphadenopathy, the oral manifestations of HSV-1 infection are gingivostomatitis and vesiculo-ulcerative eruption on the perioral skin, vermillion border, and intra-oral mucosal surface. The vesicles, after rupture, are painful as they are left to heal without scarring [62]. The herpes simplex virus migrates in later stages to the trigeminal ganglion, accounting for 15% to 30% of cases, and is affected by the reactivation of secondary herpes simplex lesions in early adulthood due to stress or infection.…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

Oral Manifestations in Monkeypox: A Scoping Review on Implications for Oral Health

Issa,

Alkhofash,

Gopinath

et al. 2023

Dentistry Journal

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Background: The monkeypox outbreak in 2022 caused concern in the public. Infected patients usually present prodromal symptoms, such as lesions on their skin and mucous membranes, including the oral cavity. The current study aims to review the most common oral/perioral manifestations reported to date. Methods: A literature search was conducted in the PubMed, Research Gate, and Wiley Online Library databases, as well as in the Google search engine, using keywords related to the condition. Of the 56 publications identified, 30 were selected, including 27 case reports, two case series types, and one cross-sectional study published from 2003 to 2023 in endemic and non-endemic countries. Of the 54 patients in these studies, data on the oral symptoms and sites of monkeypox were interpreted from 47 patients. Results: Oral/perioral signs as one of the initial manifestations were reported in 23 out of 47 patients (48.93%). Out of the 47 patients with oral/perioral involvement, the most common signs/symptoms were sore throat, followed by ulcers, vesicles, dysphagia and odynophagia, and erythema. Conclusion: The most common oral symptom of monkeypox is sore throat, followed by ulcers. The symptoms usually occur in the pharynx/oropharynx, followed by the tonsils and tongue. Adequate knowledge about the characteristics of this virus and their association with the oral cavity is necessary, and could help oral health professionals to distinguish between different infections.

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Characterization of children with recurrent eczema herpeticum and response to treatment with interferon‐gamma

Abstract: Children with confirmed eczema herpeticum have evidence of impaired innate and adaptive immunity. IFN-γ did not result in dramatic improvement in either subset. Specific evaluation for IFN-γ production, function, or receptor defects may help predict response.

Cited by 9 publications

References 15 publications

Eczema Herpeticum in children with burns

Eczema Herpeticum in children with burns

Herpeticum-like rash in a child with atopic dermatitis: early clinical suspicion is valuable

Oral Manifestations in Monkeypox: A Scoping Review on Implications for Oral Health

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