Characterization of chicken interferon-inducible transmembrane protein-10

Okuzaki, Yuya; Kidani, Shunsuke; Kaneoka, Hidenori; Iijima, Shinji; Nishijima, Ken‐ichi

doi:10.1080/09168451.2016.1274639

Cited by 5 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is reported that IFITM10 was expressed in the brain and spleen of mice, whereas not expressed in bone (31). The expression level of IFITM10 in chicken was decreased with the continuous development of embryonic germ cells (32). IFITM10 had been reported in spleen tissues, and we found that IFITM10 was also expressed in esophagus, trachea, bone and muscle.…”

Section: Discussionsupporting

confidence: 47%

The expression profile of IFITM family gene in rats

Zuo

Zhang

et al. 2017

IRDR

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 47%

The expression profile of IFITM family gene in rats

Zuo

Zhang

et al. 2017

IRDR

View full text Add to dashboard Cite

“…Therefore, some researchers question whether IFITM10 is regulated by the interferon ( 9 ). However, the existing experiments only proved that IFN-α did not have the ability to activate IFITM10 ( 10 ). Some studies have shown that the level of interferon is lower in the serum of patients with GC compared to that in normal people.…”

Section: Discussionmentioning

confidence: 99%

“…IFITM10 has the highest species conservation ( 9 ). The latest research shows that IFITM10 has weak antiviral properties ( 10 ). Fusion transcripts of IFITM10 and cathepsin D promote breast cancer proliferation ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Highly expressed IFITM10 is associated with early diagnosis and T stage of gastric cancer

Liu¹,

Liu²,

Tian³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background: Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which functions mainly include controlling cell proliferation, promoting homotypic cell adhesion, and preventing viral infection. This research study attempts to elucidate the association between IFITM10 expression level and gastric cancer (GC).Methods: Transcriptome sequencing and clinical information on GC and normal tissues was obtained from the Cancer Genome Atlas (TCGA) database. R and related statistical packages were used to analyze the relationship between IFITM10 and survival in GC patients based on available clinical information. Receiver operating characteristic curves (ROC) were constructed using the SPSS software package. IFITM10 expression levels in patients tissue samples were examined by qPCR and association between IFITM10 expression and clinic characteristics was analyzed using SPSS. The signaling pathway associated with IFITM10 was analyzed using gene set enrichment analysis (GSEA).Results: In the TCGA database, IFITM10 was highly expressed in GC tissues (P<0.001). Area under the curve (AUC) value for IFITM10 in all samples was 0.813, while AUC value in the paired GC and adjacent tissues was 0.955. In the sample of surgical patients, IFITM10 was highly expressed in GC tissues (P<0.001).IFITM10 expression was higher in T1 and T2 tissues (P=0.042), male patients (P=0.031), and tissues without neuro infiltration (P=0.008).Conclusions: IFITM10 is highly expressed in GC and can serve as an early diagnostic indicator. High expression of IFITM10 was related to a low T stage in GC.

show abstract

“…In contrast, IFITM5 and IFITM10 are insensitive to IFNs and exert indistinct antiviral functions (33,34). IFITM5, which evolved in bony fish, is highly conserved within the IFITM family based on the lack of gene duplication or positive selection detected, consistent with its functional specialization in bone development (4,31).…”

Section: Ifitm Protein Familymentioning

confidence: 95%

IFITM protein regulation and functions: Far beyond the fight against viruses

Friedlová

Kokáš²,

Hupp³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Interferons (IFNs) are important cytokines that regulate immune responses through the activation of hundreds of genes, including interferon-induced transmembrane proteins (IFITMs). This evolutionarily conserved protein family includes five functionally active homologs in humans. Despite the high sequence homology, IFITMs vary in expression, subcellular localization and function. The initially described adhesive and antiproliferative or pro-oncogenic functions of IFITM proteins were diluted by the discovery of their antiviral properties. The large set of viruses that is inhibited by these proteins is constantly expanding, as are the possible mechanisms of action. In addition to their beneficial antiviral effects, IFITM proteins are often upregulated in a broad spectrum of cancers. IFITM proteins have been linked to most hallmarks of cancer, including tumor cell proliferation, therapeutic resistance, angiogenesis, invasion, and metastasis. Recent studies have described the involvement of IFITM proteins in antitumor immunity. This review summarizes various levels of IFITM protein regulation and the physiological and pathological functions of these proteins, with an emphasis on tumorigenesis and antitumor immunity.

show abstract

Characterization of chicken interferon-inducible transmembrane protein-10

Cited by 5 publications

References 31 publications

The expression profile of IFITM family gene in rats

The expression profile of IFITM family gene in rats

Highly expressed IFITM10 is associated with early diagnosis and T stage of gastric cancer

IFITM protein regulation and functions: Far beyond the fight against viruses

Contact Info

Product

Resources

About