Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia

Anderson, Cindy M.; Lopez, Faye L.; Zhang, Haiying; Pavlish, Kristin; Benoit, Joseph N.

doi:10.1016/j.ajog.2004.11.010

Cited by 20 publications

(14 citation statements)

References 21 publications

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“…It has been noted that elevated plasma lipid and lipoproteins may induce endothelial dysfunction secondary to oxidative stress and that dyslipidemia may impair trophoblast invasion, thus contributing to a cascade of pathophysiological events that lead to the development of pre-eclampsia (Lorentzen & Henrisksen 1998). Consistent with our results on the lower leptin serum levels in SHR strain, Anderson et al (2005) found a significant decrease of leptinemia in reduced uterine perfusion pressure (RUPP) animals. RUPP is an animal model of pre-eclampsia characterized by persistent elevation of arterial pressure, reduced litter size, fetal, and placental weights.…”

Section: Discussionsupporting

confidence: 92%

Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation

Raso

Bianco

Iacono

et al. 2007

Journal of Endocrinology

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Leptin and/or ghrelin, initially thought to be considered messengers of energy metabolism, are now considered to play a role in normal and complicated pregnancy. In this study, pregnant, spontaneously hypertensive rats (SHR) have been used to evaluate, for the first time, the modification of leptin and ghrelin both at serum and tissue levels. In SHR, we evaluate plasma leptin level and tissue protein expression in both placenta and adipose tissue at the end of gestation (day 20) versus normotensive Wistar-Kyoto (WKY) animals. The expression of functional leptin receptor (Ob-Rb) in peripheral tissues and in the hypothalamus was evaluated. Moreover, we measured plasma ghrelin level and its mRNA expression in the stomach and placenta. SHR strain presented significantly lower plasma leptin levels when compared with those found in pregnant or not WKY controls. Interestingly, in the placenta, leptin gene expression was higher in SHR than normotensive WKY. Moreover, we demonstrated a resistance to the effects of leptin via 'downregulation' of hypothalamic receptors in pregnant SHR. Conversely, SHR presented significantly higher ghrelin plasma levels when compared with those found in pregnant or not WKY. However, we observed that ghrelin level in the stomach of SHR did not change during pregnancy, and on the opposite, mRNA ghrelin in the placenta of SHR was lower than that of normotensive rats, suggesting a different production of this hormone in the fetal-placental unit. These data gain further insight into metabolic hormone modifications observed in a model of pre-existing hypertension associated with pregnancy.

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Section: Discussionsupporting

confidence: 92%

Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation

Raso

Bianco

Iacono

et al. 2007

Journal of Endocrinology

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“…Visfatin and leptin are not only constitutively expressed in myometrium, but also in placenta and foetal membranes [13][14][15][16][24][25][26]. In myometrium the direct relaxant role that we have found for visfatin may counteract a contractile drive coming from its release by the placental membranes.…”

Section: Discussionmentioning

confidence: 67%

“…Leptin, a hormone that regulates appetite and energy metabolism, is synthesized in adipose tissue and is under the control of obesity genes [12]. However it is also synthesized by the placenta [13,14], and its levels increase in maternal blood during pregnancy [15,16]. Its receptor is expressed in human umbilical cord, foetal membrane and uterine tissue.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

et al. 2015

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“…The RUPP rat mimics numerous physiological features of preeclampsia in women (see Table 3), including hypertension (ϳ20 -30 mmHg increase in mean arterial pressure), proteinuria (ϳ5-fold increase in urinary protein excretion), impaired renal function, as indicated by reduction in glomerular filtration rate (GFR) (Ͻ40%) and renal plasma flow (Ͻ23%), an increase in vascular reactivity, a reduction in cardiac index (90), and increases in leptin (14) and blood lactate (36). Fetal IUGR also occurs in RUPP rats, with decreased litter size and pup weight (10,40).…”

Section: Characteristics Of the Rupp Modelmentioning

confidence: 99%

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

LaMarca

Reckelhoff

2012

American Journal of Physiology-Heart and Circulatory Physiology

171

137

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Preeclampsia is defined as new-onset hypertension with proteinuria after 20 wk gestation and is hypothesized to be due to shallow trophoblast invasion in the spiral arteries thus resulting in progressive placental ischemia as the fetus grows. Many animal models have been developed that mimic changes in maternal circulation or immune function associated with preeclampsia. The model of reduced uterine perfusion pressure in pregnant rats closely mimics the hypertension, immune system abnormalities, systemic and renal vasoconstriction, and oxidative stress in the mother, and intrauterine growth restriction found in the offspring. The model has been successfully used in many species; however, rat and primate are the most consistent in comparison of characteristics with human preeclampsia. The model suffers, however, from lack of the ability to study the mechanisms responsible for abnormal placentation that ultimately leads to placental ischemia. Despite this limitation, the model is excellent for studying the consequences of reduced uterine blood flow as it mimics many of the salient features of preeclampsia during the last weeks of gestation in humans. This review discusses these features.

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Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia

Cited by 20 publications

References 21 publications

Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation

Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation

Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

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