Characterization of CD4+ T Cell Autoreactivity to Self-MHC in New Zealand Hybrid Mice

Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus

“…Multi‐organ compromise may arise as a consequence of the deposition of immune complexes in blood vessels, which leads to macrophage and complement activation, inflammation and tissue damage 4–7 . Abnormalities in almost every component of the immune system have been described in patients with SLE and in mouse models of SLE, including the presence of activated autoreactive CD4 + T cells that drive the subsequent activation of self‐reactive B cells, leading to the production of autoantibodies 8–10 . In addition, peripheral blood monocytes derived from patients with SLE display an abnormal phenotype, characterized by deregulated expression of HLA‐DR and CD14, which could lead to defects in antigen presentation by monocyte‐derived antigen‐presenting cells, such as dendritic cells (DCs) or macrophages 11,12 .…”

“…activation of self-reactive B cells, leading to the production of autoantibodies. [8][9][10] In addition, peripheral blood monocytes derived from patients with SLE display an abnormal phenotype, characterized by deregulated expression of HLA-DR and CD14, which could lead to defects in antigen presentation by monocyte-derived antigen-presenting cells, such as dendritic cells (DCs) or macrophages. 11,12 These alterations are likely to contribute to autoreactive T-cell priming during the onset of SLE.…”

B Cells and Dendritic Cells from Vκ8 Light Chain Transgenic Mice Activate MRL-lpr/gldCD4+ T Cells

“…In fact, Ͼ50% of T cell hybridomas derived from the spleen and lymph nodes of unimmunized (NZB ϫ NZW)F 1 mice respond to syngeneic spleen cells in the absence of exogenous Ag (18). However, the Ag specificity of these self-reactive T cells remains largely unknown, although recognition of various autoantigens including nucleosome, histone, ribonucleoprotein, and self-Ig have been described previously (19 -23).…”