Characterization of cat nasal afferents and brain stem neurones receiving ethmoidal input

Lucier, Gregory E.; Egizii, Rita

doi:10.1016/0014-4886(89)90189-1

Cited by 43 publications

(17 citation statements)

References 24 publications

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“…These afferents are likely part of the ethmoidal nerve, 22 a branch of the ophthalmic nerve that innervates the nasal mucosa. 4 We also found nasal afferent cell bodies located in a small area on the dorsal surface of the ganglion that is the source of the maxillary branch. These afferents are possibly part of the posterior nasal nerve or the nasal branch of the infraorbital nerve.…”

Section: Discussionmentioning

confidence: 96%

“…The nasal mucosa is innervated by 2 distinct afferent sensory pathways: the olfactory nerve (cranial nerve I), which encodes information for the sensation of smell, and the trigeminal nerve (cranial nerve V), which encodes a wide variety of information on temperature, touch, airflow, occlusion, and chemosensitivity. [1][2][3][4] Allergic inflammation of the nasal mucosa causes varying degrees of nasal blockage, sneezing, itch, and rhinorrhea. 5 In addition to the neuronally mediated sneeze and nasal itch, a substantial portion of rhinorrhea is the parasympathetic-mediated reflex hypersecretion, 6 and there is evidence supporting a role for afferent-released neuropeptides such as substance P contributing to nasal blockage.…”

mentioning

confidence: 99%

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Nasal sensory nerve populations responding to histamine and capsaicin

Taylor‐Clark

Kollárik

MacGlashan

et al. 2005

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Nasal sensory nerve populations responding to histamine and capsaicin

Taylor‐Clark

Kollárik

MacGlashan

et al. 2005

Journal of Allergy and Clinical Immunology

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“…Aδ fibers convey initial sharp pain ("first pain"). In the feline nose, there appears to be a set of low-threshold mechanoreceptive Aδ fibers that are sensitive only to light touch and a set of chemomechanical-sensitive fibers that synapse on wide dynamic range neurons in the spinal cord dorsal horn [9]. The feline anterior ethmoid nerve contains 6000 C, 650 Aδ, and 350 Aβ fibers [10].…”

Section: Aδ δ δ δ and C Fibersmentioning

confidence: 99%

Neurogenic mechanisms in rhinosinusitis

Baraniuk

2001

Curr Allergy Asthma Rep

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Nasal sensory nerve stimulation leads to sensations of pain and congestion and nociceptive nerve axon response-mediated release of substance P that stimulates glandular secretion as an immediate-acting protective mucosal defense. Recruited parasympathetic reflexes cause submucosal gland secretion via muscarinic M3 receptors. Parasympathetic reflexes, sneezing, and other avoidance behaviors rapidly clear the upper airway of offending agents while protecting the lower airways. Dysfunction contributes to allergic, infectious, and other nonallergic rhinitides and possibly sinusitis. Sympathetic arterial vasoconstriction reduces mucosal blood flow, sinusoidal filling, and mucosal thickness, restoring nasal patency. Loss of sympathetic tone may contribute to some chronic, nonallergic rhinopathies.

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“…Most of these fibers are sensory in function (Lucier and Egizii, 1989; Wallois et al, 1991, 1992; Sekizawa and Tsubone, 1994, 1996), and many respond as chemoreceptors (Lucier and Egizii, 1989), creating the “common chemical sense” or chemethesis (Cain and Murphy, 1980; Green and Lawless, 1991; Viana, 2011). Moreover, such sensations, including pain, can be elicited from stimulating the human nasal mucosa (Handwerker and Kobal, 1993; Thürauf et al, Cometto-Muñiz and Cain, 1997; 1993; Cometto-Muniz et al, 1998, 2001; Hummel et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Direct reticular projections of trigeminal sensory fibers immunoreactive to CGRP: potential monosynaptic somatoautonomic projections

Panneton

Gan

2014

Front. Neurosci.

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Few trigeminal sensory fibers project centrally beyond the trigeminal sensory complex, with only projections of fibers carried in its sensory anterior ethmoidal (AEN) and intraoral nerves described. Fibers of the AEN project into the brainstem reticular formation where immunoreactivity against substance P and CGRP are found. We investigated whether the source of these peptides could be from trigeminal ganglion neurons by performing unilateral rhizotomies of the trigeminal root and looking for absence of label. After an 8–14 days survival, substance P immunoreactivity in the trigeminal sensory complex was diminished, but we could not conclude that the sole source of this peptide in the lateral parabrachial area and lateral reticular formation arises from primary afferent fibers. Immunoreactivity to CGRP after rhizotomy however was greatly diminished in the trigeminal sensory complex, confirming the observations of others. Moreover, CGRP immunoreactivity was nearly eliminated in fibers in the lateral parabrachial area, the caudal ventrolateral medulla, both the peri-ambiguus and ventral parts of the rostral ventrolateral medulla, in the external formation of the nucleus ambiguus, and diminished in the caudal pressor area. The nearly complete elimination of CGRP in the lateral reticular formation after rhizotomy suggests this peptide is carried in primary afferent fibers. Moreover, the arborization of CGRP immunoreactive fibers in these areas mimics that of direct projections from the AEN. Since electrical stimulation of the AEN induces cardiorespiratory adjustments including an apnea, peripheral vasoconstriction, and bradycardia similar to those seen in the mammalian diving response, we suggest these perturbations of autonomic behavior are enhanced by direct somatic primary afferent projections to these reticular neurons. We believe this to be first description of potential direct somatoautonomic projections to brainstem neurons regulating autonomic activity.

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Characterization of cat nasal afferents and brain stem neurones receiving ethmoidal input

Cited by 43 publications

References 24 publications

Nasal sensory nerve populations responding to histamine and capsaicin

Nasal sensory nerve populations responding to histamine and capsaicin

Neurogenic mechanisms in rhinosinusitis

Direct reticular projections of trigeminal sensory fibers immunoreactive to CGRP: potential monosynaptic somatoautonomic projections

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