Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar

Giovambattista, Guillermo; Moe, Kyaw Kyaw; Polat, Meripet; Borjigin, Liushiqi; Hein, Si Thu; Moe, Hla Hla; Takeshima, Shin Nosuke; Aida, Yoko

doi:10.1186/s12863-020-00905-8

Cited by 15 publications

(12 citation statements)

References 52 publications

(118 reference statements)

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“…Besides, the genetic characterization of cattle raised in different regions may show a greater divergence as a result of natural selection or artificial selection and crossbreeding. 20,21,[25][26][27][28][29][30][31] Therefore, the genetic characterization and the association between the BoLA-DRB3 and the resistance or susceptibility to BLV infection should be further investigated in different regions and in distinct cattle breeds. There is an increasing effort to characterize the diversity of BoLA-DRB3 by breed and location.…”

Section: Bola-drb3 and Blv In Vietnamese Hf Cattle Association Of Blv Proviral Load With Bola-drb3 Polymorphismmentioning

confidence: 99%

Association between BoLA‐DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle

Thi

et al. 2022

HLA

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Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis.Polymorphism in bovine leukocyte antigen (BoLA)-DRB3 allele can influence the host immune response to pathogens, including BLV. However, association between specific BoLA-DRB3 alleles and BLV proviral load (PVL), which is a useful index for estimating disease progression and transmission risk, in Vietnamese cattle are unknown. Here, association study of BoLA-DRB3 allele frequency between cattle with high or low PVL demonstrated BoLA-DRB3*12:01 associates with high PVL in Vietnamese Holstein Friesian (HF) crossbred cattle. This is the first study to demonstrate that BoLA-DRB3 polymorphism confers susceptibility to BLV high PVL in HF crossbred kept in Vietnam. Our results may be useful in disease control and eradiation for BLV through genetic selection.

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Section: Bola-drb3 and Blv In Vietnamese Hf Cattle Association Of Blv Proviral Load With Bola-drb3 Polymorphismmentioning

confidence: 99%

Association between BoLA‐DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle

Thi

et al. 2022

HLA

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“…The one study that involved genomic data based on RFLP analysis also assessed different already mentioned diversity parameters, with the application of Popgene and Cervus [148,149]. Giovambattista et al [150] analyzed genomic data based on BoLA-DRB3 alleles genotyping. With this, different parameters were assessed while using different programs to shed light on the genetic diversity of local cattle populations in Myanmar.…”

Section: Diversity Parameters and Evaluation Softwarementioning

confidence: 99%

An Overview of the Use of Genotyping Techniques for Assessing Genetic Diversity in Local Farm Animal Breeds

Olschewsky

Hinrichs

2021

Animals

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Globally, many local farm animal breeds are threatened with extinction. However, these breeds contribute to the high amount of genetic diversity required to combat unforeseen future challenges of livestock production systems. To assess genetic diversity, various genotyping techniques have been developed. Based on the respective genomic information, different parameters, e.g., heterozygosity, allele frequencies and inbreeding coefficient, can be measured in order to reveal genetic diversity between and within breeds. The aim of the present work was to shed light on the use of genotyping techniques in the field of local farm animal breeds. Therefore, a total of 133 studies across the world that examined genetic diversity in local cattle, sheep, goat, chicken and pig breeds were reviewed. The results show that diversity of cattle was most often investigated with microsatellite use as the main technique. Furthermore, a large variety of diversity parameters that were calculated with different programs were identified. For 15% of the included studies, the used genotypes are publicly available, and, in 6%, phenotypes were recorded. In conclusion, the present results provide a comprehensive overview of the application of genotyping techniques in the field of local breeds. This can provide helpful insights to advance the conservation of breeds.

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“…DRB3 has been characterised in bovine species in various breeds and populations worldwide [57][58][59]; Mandefro et al (2021) showed a difference regarding BoLA-DRB3 genetic variability between African and Asiatic breeds. A study of DRB3 locus diversity by Peters et al, (2018) analysed Asian populations and compared African and American populations; 15 haplotypes were reported from the 174 cattle analysed, the Brangus (10), Sokoto Gudali (10), and Dajal ( 9) breeds having the greatest number of haplotypes whilst only four haplotypes were found in the Holstein and Sahiwal group.…”

Section: Genetic Variability and Immune Responsementioning

confidence: 99%

Nanovaccines against Animal Pathogens: The Latest Findings

et al. 2021

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Nowadays, safe and efficacious vaccines represent powerful and cost-effective tools for global health and economic growth. In the veterinary field, these are undoubtedly key tools for improving productivity and fighting zoonoses. However, cases of persistent infections, rapidly evolving pathogens having high variability or emerging/re-emerging pathogens for which no effective vaccines have been developed point out the continuing need for new vaccine alternatives to control outbreaks. Most licensed vaccines have been successfully used for many years now; however, they have intrinsic limitations, such as variable efficacy, adverse effects, and some shortcomings. More effective adjuvants and novel delivery systems may foster real vaccine effectiveness and timely implementation. Emerging vaccine technologies involving nanoparticles such as self-assembling proteins, virus-like particles, liposomes, virosomes, and polymeric nanoparticles offer novel, safe, and high-potential approaches to address many vaccine development-related challenges. Nanotechnology is accelerating the evolution of vaccines because nanomaterials having encapsulation ability and very advantageous properties due to their size and surface area serve as effective vehicles for antigen delivery and immunostimulatory agents. This review discusses the requirements for an effective, broad-coverage-elicited immune response, the main nanoplatforms for producing it, and the latest nanovaccine applications for fighting animal pathogens.

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Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar

Cited by 15 publications

References 52 publications

Association between BoLA‐DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle

Association between BoLA‐DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle

An Overview of the Use of Genotyping Techniques for Assessing Genetic Diversity in Local Farm Animal Breeds

Nanovaccines against Animal Pathogens: The Latest Findings

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