Characterization of biosurfactant produced by the endophyte Burkholderia sp. WYAT7 and evaluation of its antibacterial and antibiofilm potentials

Ashitha, A.; E.K, Radhakrishnan; Mathew, Jyothis

doi:10.1016/j.jbiotec.2020.03.005

Cited by 60 publications

(10 citation statements)

References 43 publications

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“…Glycolipid isolated from Burkholderia sp. WYAT7, an endophyte of Artemisia nilagirica (Clarke) Pamp, has anti-biofilm activity against S. aureus (Ashitha et al, 2020). A broad-range glycolipoprotein, rich in Leu-His-Trp amino acids identified from Acinetobacter indicus M6 has low toxicity and removed 82.5% of biofilm at a concentration of 500 µg/ml (Karlapudi et al, 2020).…”

Section: Biosurfactantsmentioning

confidence: 99%

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Mishra¹,

Panda²,

et al. 2020

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Pathogenic microorganisms and their chronic pathogenicity are significant concerns in biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident multidrug-resistant microbes. Low efficiency of various treatments and in vivo toxicity of available antibiotics drive the researchers toward the discovery of many effective natural anti-biofilm agents. Natural extracts and natural product-based antibiofilm agents are more efficient than the chemically synthesized counterparts with lesser side effects. The present review primarily focuses on various natural anti-biofilm agents, i.e., phytochemicals, biosurfactants, antimicrobial peptides, and microbial enzymes along with their sources, mechanism of action via interfering in the quorum-sensing pathways, disruption of extracellular polymeric substance, adhesion mechanism, and their inhibitory concentrations existing in literature so far. This study provides a better understanding that a particular natural anti-biofilm molecule exhibits a different mode of actions and biofilm inhibitory activity against more than one pathogenic species. This information can be exploited further to improve the therapeutic strategy by a combination of more than one natural anti-biofilm compounds from diverse sources.

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Section: Biosurfactantsmentioning

confidence: 99%

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Mishra¹,

Panda²,

et al. 2020

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“…The wide distribution of species in Proteobacteria demonstrates the potential to decompose recalcitrant carbon sources for use, showing that microorganisms using a K-strategy play an important role in driving the formation of a certain community structure, a slow and stable evolutionary progress . For the dechlorinating bacterium Dechloromonas , its co-occurring genera in Sphingomonadaceae and Burkholderiaceae can degrade phenanthrene into simple organic matter as a substrate or produce biological surfactants, that can support degraders in mutualism. Other co-occurring Pseudogulbenkiania was reported to be dominant with Dechloromonas in a chlorinated paraffins contaminated groundwater plume, which was identified as core microbiomes in this study, and Lysobacter exhibited a greater relative abundance in chlorinated systems .…”

Section: Discussionmentioning

confidence: 99%

Investigating Biodegradation of 1,4-Dioxane by Groundwater and Soil Microbiomes: Insights into Microbial Ecology and Process Prediction

Miao,

Zhou,

Zheng

et al. 2023

ACS EST Water

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Although microorganisms play significant roles in bioremediation, their contributions to long-term site characteristics during and after active treatment need to be fully elucidated. This study described microbial ecology dynamics in 1,4-dioxane- and chlorinated solvents-contaminated groundwater in laboratory microcosms. Bioaugmented Pseudonocardia dioxanivorans CB1190 improved 1,4-dioxane removal, with increased carbohydrate and amino acid metabolism, but was eventually outcompeted by native microbes. The original microbiomes were perturbed and divergent but tended to be similar over time. Dechlorinating bacteria co-existed in the same niche, whereas CB1190 had more negative interactions in the shared niche. Multiple regression and classification machine learning models were built by using microbial taxa to predict the degradation process; the ensemble regression model provided most accurate prediction of 1,4-dioxane concentrations (R 2 = 0.81 ± 0.17). Among the classification models, the support vector machine performed the best in differentiating the contamination levels (accuracy at 0.67 ± 0.07, kappa at 0.56 ± 0.10). The ensemble model predicted the 1,4-dioxane concentrations and relative duration of contamination with independent microbial datasets from a field study, and the results aligned with the geographic and hydrological information from monitoring wells. This study introduces the application of machine learning in microbiome-based diagnostics for groundwater remediation and evaluation, providing valuable methods for future research and practice.

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“…For topical application, these drug delivery systems can be formulated in semisolid hydrogels that can be exploited against skin drug-resistant infections and for wound treatment. Several [140] identified the glycolipid biosurfactant produced by Burkholderia sp. WYAT7 isolated from the medicinal plant Artemisia nilagirica (Clarke) Pamp and evaluated its antibacterial and antibiofilm potential.…”

Section: Discussionmentioning

confidence: 99%

“…Ashitha et al (2020) [140] identified the glycolipid biosurfactant produced by Burkholderia sp. WYAT7 isolated from the medicinal plant Artemisia nilagirica (Clarke) Pamp and evaluated its antibacterial and antibiofilm potential.…”

Section: Ecotoxicologymentioning

confidence: 99%

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Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology

et al. 2021

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Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms’ activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug delivery systems for a range of molecules given their capacity to create micelles which can promote the encapsulation of bioactives of pharmaceutical interest; besides, these assemblies can also show antimicrobial properties. The advantages of biosurfactants include their high biodegradability profile, low risk of toxicity, production from renewable sources, functionality under extreme pH and temperature conditions, and long-term physicochemical stability. The application potential of these types of polymers is related to their properties enabling them to be processed by emulsification, separation, solubilization, surface (interfacial) tension, and adsorption for the production of a range of drug delivery systems. Biosurfactants have been employed as a drug delivery system to improve the bioavailability of a good number of drugs that exhibit low aqueous solubility. The great potential of these molecules is related to their auto assembly and emulsification capacity. Biosurfactants produced from bacteria are of particular interest due to their antibacterial, antifungal, and antiviral properties with therapeutic and biomedical potential. In this review, we discuss recent advances and perspectives of biosurfactants with antimicrobial properties and how they can be used as structures to develop semisolid hydrogels for drug delivery, in environmental bioremediation, in biotechnology for the reduction of production costs and also their ecotoxicological impact as pesticide alternative.

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Characterization of biosurfactant produced by the endophyte Burkholderia sp. WYAT7 and evaluation of its antibacterial and antibiofilm potentials

Cited by 60 publications

References 43 publications

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Investigating Biodegradation of 1,4-Dioxane by Groundwater and Soil Microbiomes: Insights into Microbial Ecology and Process Prediction

Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology

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