Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery

Kale, S. N.; Jadhav, Anil D.; Verma, Seema; Koppikar, Soumya J.; Kaul-Ghanekar, Ruchika; Dhole, S.D.; Ogale, Satishchandra

doi:10.1016/j.nano.2011.07.010

Cited by 53 publications

(27 citation statements)

References 29 publications

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“…Kale et al were able to heat in-house-produced nickel nanoparticles up to 75 ° C within 2 min in vitro , which is a very promising result regarding their use in hyperthermia or thermal ablation [82] . Balivada et al found an anticancer effect in mice after injecting magnetic nanoparticles either directly into the tumor or intravenously, followed by the exposure to an alternating magnetic field [27] .…”

Section: Thermal Ablationmentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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Abstract:Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of " theranostics " . The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

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Section: Thermal Ablationmentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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“…The distribution of the cationic oxidation states is a matter of some uncertainty [2][3][4] and appears to reflect the type of characterization technique and synthesis method employed. This material is widely used in the field magnetic materials [3,4], electrocatalysts [1,5], chemical sensors [6] and biomedical applications [7]. Commonly, NiCo 2 O 4 is obtained through the mechanical mixture of oxides.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of NiCo2O4 spinel using gelatin as an organic precursor

et al. 2012

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“…92 Nanovectors based on the three ferromagnetic elements Co, Ni, and Fe can be used either to mediate a hyperthermic effect (predominantly causing tumor necrosis) or to deliver drugs to achieve intratumoral levels. Nickel-based nanomaterials have also been reported for tumor targeting by serving either as inducers of hyperthermia in response to an externally applied magnetic field (as drug-delivery platforms) 93 or directly as proapoptotic mediators. 94 Liu et al synthesized a Co-and Cu-based nonviral carrier for DNA transfer in gene therapy.…”

Section: Magnetic Nanovectors For Drug Deliverymentioning

confidence: 99%

Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

139

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Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

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Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery

Cited by 53 publications

References 29 publications

Magnetic nanoparticles for cancer therapy

Magnetic nanoparticles for cancer therapy

Synthesis and characterization of NiCo2O4 spinel using gelatin as an organic precursor

Nanotechnology-based approaches in anticancer research

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