Characterization of bioactive compound produced by microfouling actinobacteria (Micrococcus Luteus) isolated from the ship hull in Arabian Sea, Cochin. Kerala

Nisha, P.; John, Nayomi; Mamatha, C.; Thomas, Manuel

doi:10.1016/j.matpr.2020.01.362

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…In one study, carotenoids purified from M. luteus , only identified as “yellow carotenoid pigment”, were observed to have antibacterial effects against Staphylococcus aureus and Streptococcus faecalis (now classified as Enterococcus faecalis ) (Mohana et al., 2013 ). Another study found the crude pigment extract of M. luteus to be additionally active against Salmonella typhi and several drug-resistant bacteria, including multidrug-resistant Acinetobacter sp., multidrug-resistant Pseudomonas , methicillin-resistant Staphylococcus sp., and Enterobacter carbopenum and confirmed antifungal activity (Nisha et al., 2019 ). Furthermore, the crude pigment displayed antitumor activity against Dalton's Lymphoma ascites cells.…”

Section: Bioactive Pigmentsmentioning

confidence: 75%

“…In addition, crude exopolysaccharides from M. luteus were found to be variably active against Escherichia coli, Klebsiella sp., S. typhi, Staphylococcus sp., and Pseudomonas sp. (Nisha et al., 2019 ).…”

Section: Bioactive Pigmentsmentioning

confidence: 99%

“…Aside from characterization studies, the majority of the literature on Micrococcus spp. focuses on the pigments they produce, documenting their antioxidant, antibiotic, antifungal, and anticancer properties (Mohana et al., 2013 ; Umadevi & Krishnaveni, 2013 ; Ushasri & Gods Will Shalomi, 2015 ; Rostami et al., 2016 ; Majeed, 2017 ; Zehra et al., 2018 ; Nisha et al., 2019 ; Karbalaei-Heidari et al., 2020 ; Shukla & Nadumane, 2021 ; Shahin et al., 2022 ). The major carotenoid pigment of M. luteus , sarcinaxanthin, is a rare C 50 carotenoid that functions as an antioxidant and has been patented for use in sunscreen, although this patent has since been abandoned (Goksøyr, 2013 ; Netzer et al., 2010 ).…”

Section: Bioactive Pigmentsmentioning

confidence: 99%

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Micrococcus spp. as a promising source for drug discovery: A review

Tizabi

Hill

2023

Journal of Industrial Microbiology and Biotechnology

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Historically, bacteria of the phylum Actinobacteria have been a very prominent source of bioactive compounds for drug discovery. Among the actinobacterial genera, Micrococcus has not generally been prioritized in the search for novel drugs. The bacteria in this genus are known to have very small genomes (generally < 3 Mb). Actinobacteria with small genomes seldom contain the well-characterized biosynthetic gene clusters such as those encoding polyketide synthases and nonribosomal peptide synthetases that current genome mining algorithms are optimized to detect. Nevertheless, there are many reports of substantial pharmaceutically-relevant bioactivity of Micrococcus extracts. On the other hand, there are remarkably few descriptions of fully characterized and structurally-elucidated bioactive compounds from Micrococcus spp. This review provides a comprehensive summary of the bioactivity of Micrococcus spp., which encompasses antibacterial, antifungal, cytotoxic, antioxidant and anti-inflammatory activities. This review uncovers the considerable biosynthetic potential of this genus and highlights the need for a re-examination of these bioactive strains, with a particular emphasis on marine isolates, because of their potent bioactivity and high potential for encoding unique molecular scaffolds.

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Section: Bioactive Pigmentsmentioning

confidence: 75%

Section: Bioactive Pigmentsmentioning

confidence: 99%

Section: Bioactive Pigmentsmentioning

confidence: 99%

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Micrococcus spp. as a promising source for drug discovery: A review

Tizabi

Hill

2023

Journal of Industrial Microbiology and Biotechnology

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“…A mass spectrometry analysis classified the small molecule as pumilacidin, a non-ribosomally synthesized biosurfactant that is active against Staphylococcus. Nisha et al [49] characterized exopolysaccharides (EPS) produced by the marine bacterium Micrococcus luteus isolated from a ship hull at Cochin port, India. An EPS-associated compound from M. luteus was isolated and characterized, and the results showed antibacterial and antifungal activities against pathogens.…”

Section: Products From Marine Isolatesmentioning

confidence: 99%

Shallow Hydrothermal Vent Bacteria and Their Secondary Metabolites with a Particular Focus on Bacillus

et al. 2021

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Extreme environments are hostile for most organisms, but such habitats represent suitable settings to be inhabited by specialized microorganisms. A marine shallow-water hydrothermal vent field is located offshore in northeast Taiwan, near the shallow shore of the southeast of Kueishantao Island (121°55′ E, 24°50′ N). Research on extremophilic microorganisms makes use of the biotechnological potential associated with such microorganisms and their cellular products. With the notion that extremophiles are capable of surviving in extreme environments, it is assumed that their metabolites are adapted to function optimally under such conditions. As extremophiles, they need specific culture conditions, and only a fraction of species from the original samples are recovered in culture. We used different non-selective and selective media to isolate bacterial species associated with the hydrothermal vent crab Xenograpsus testudinatus and the sediments of its habitat. The highest number of colonies was obtained from Zobell marine agar plates with an overall number of 29 genetically distinct isolates. 16sRNA gene sequencing using the Sanger sequencing method revealed that most of the bacterial species belonged to the phylum Firmicutes and the class Bacilli. The present study indicates that hydrothermal vent bacteria and their secondary metabolites may play an important role for the reconstruction of the evolutionary history of the phylum Procaryota.

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“…The earth plane has 70 % of marine environment and the ocean is rich in unexplored potential sources for countless drugs and secondary metabolites [6] . The ocean is believed to be highest resource of powerful compounds and symbolize a considerable number of microbes which are producing the drugs [7] . Numerous actinomycetes are scattered in the aquatic environments like oceans, rivers and seas.…”

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confidence: 99%

Augmenting Bioactive Metabolite Synthesis from Streptomyces Species Isolated from Mangrove Sediments through Physio-Chemical Parameters

Aarthi¹,

Gunasekaran²,

Veluchamy³

2022

IJPS

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Augmenting Bioactive Metabolite Synthesis from Streptomyces SpeciesActinomycetes were isolated from the sediment samples collected from Pichavaram Mangrove forest in Thandavarayan Sholagan Pet, Chidambaram Taluk, Cuddalore district, Tamilnadu, South India. The actinomycetes were screened for antibacterial (bioactive metabolite) production against Gram positive and Gram negative bacterial organisms. Molecular characterization was performed through 16S rRNA gene amplification to identify the actinomycetes. Standardization of media was done by designing the media at various pH, incubation temperature and sodium chloride concentration and incubation time. It is concluded that four actinomycetes were able to synthesis bioactive metabolite and two actinomycetes (PMA2 and PMA6) were characterized at molecular level as Streptomyces species. They grow better at pH 7.0 and the optimum temperature was found to be 34-37°. PMA2 tolerates up to 5 % sodium chloride concentration, whereas PMA6 tolerates up to 7.5 %. Minimum 7 d of incubation time is necessary for the growth of actinomycetes and concurrently, the antibacterials were peaked from 8th d.

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Characterization of bioactive compound produced by microfouling actinobacteria (Micrococcus Luteus) isolated from the ship hull in Arabian Sea, Cochin. Kerala

Cited by 10 publications

References 25 publications

Micrococcus spp. as a promising source for drug discovery: A review

Micrococcus spp. as a promising source for drug discovery: A review

Shallow Hydrothermal Vent Bacteria and Their Secondary Metabolites with a Particular Focus on Bacillus

Augmenting Bioactive Metabolite Synthesis from Streptomyces Species Isolated from Mangrove Sediments through Physio-Chemical Parameters

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