Characterization of Bioactive Components in Edible Algae

Pereira, Leonel

doi:10.3390/md18010065

Cited by 19 publications

(10 citation statements)

References 18 publications

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“…Polyphenols are one of the most known natural bioactive compounds for their antioxidant potential. They are found in several phytoplankton species (Agatonovic-Kustrin & Morton, 2018;Zolotareva et al, 2019;Pereira, 2020;Ibrahim et al, 2022). The antioxidant activity of polyphenolic compounds depends primarily on (1) Combining with free radicals, stabilizing, and deactivating them, (2) Regulating the expression and metabolic pathways of certain enzymes involved in balancing the intracellular antioxidant levels, and (3) Chelating metal ions such as copper and iron through their powerful abilities to donate hydrogen atoms and/or electrons (Li et al, 2011;Nimse & Pal, 2015;Ismail et al, 2020b).…”

Section: Polyphenolics (Phenolic Acids and Flavonoids)mentioning

confidence: 99%

Medicinal and Pharmaceutical Applications of Seaweeds

El‐Sheekh

Fathy²,

Saber³

et al. 2022

Egypt. J. Bot.

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Egyptian Journal of Botany http://ejbo.journals.ekb.eg/ 2022 S EAWEEDS are an indispensable natural source of bioactive metabolites characterized by multifunctional biomedical and pharmaceutical applications. For instance, seaweedderived polyphenolics are potentially distinguished by their pivotal antioxidant effects in the treatment and/or prevention of several diseases. Moreover, pigments, fatty acids, terpenes, and terpenoids have been characterized by their potent antioxidant, anti-inflammatory, and antiobesity properties, besides their highly effective hepatoprotective activities. Several seaweedextracted polysaccharides, such as alginates, ulvans, and carrageenans, have been reported to exert various medicinal effects such as immunoinflammatory, antioxidant, antitumor, antiviral, and anticoagulant activities. Furthermore, seaweed-derived minerals have been widely utilized as food supplements and cosmeceuticals. This review discusses and emphasizes the biomedical and pharmaceutical applications of seaweeds and the future perspectives for their large-scale applications to develop novel, safe, and high-valued pharmaceutical constituents.

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Section: Polyphenolics (Phenolic Acids and Flavonoids)mentioning

confidence: 99%

Medicinal and Pharmaceutical Applications of Seaweeds

El‐Sheekh

Fathy²,

Saber³

et al. 2022

Egypt. J. Bot.

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“…These advancements hold great potential in expanding the application of algae in the field of cancer therapy. 7 In the field of tumor therapy, algae can be utilized for tumor diagnosis through imaging techniques. They can be engineered to specifically target and identify tumor cells, aiding in the detection and localization of tumors.…”

Section: Introductionmentioning

confidence: 99%

Algae: A Robust Living Material Against Cancer

Xin,

Zhang,

Cui

et al. 2023

IJN

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Cancer is the second leading cause of death worldwide. Its incidence has been increasing in recent years, and it is becoming a major threat to human health. Conventional cancer treatment strategies, including surgery, chemotherapy, and radiotherapy, have faced problems such as drug resistance, toxic side effects and unsatisfactory therapeutic efficacy. Therefore, better development and utilization of biomaterials can improve the specificity and efficacy of tumor therapy. Algae, as a novel living material, possesses good biocompatibility. Although some reviews have elucidated several algae-based biomaterials for cancer treatment, the majority of the literature has focused on a limited number of algae. As a result, there is currently a lack of comprehensive reviews on the subject of anticancer algae. This review aims to address this gap by conducting a thorough examination of algal species that show potential for anticancer activity. Furthermore, our review will also elucidate the engineering strategies of algae and discuss the challenges and prospects associated with their implementation.

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“…Seaweeds, also known as marine macroalgae, have been recently used in several industrial and pharmaceutical applications, such as novel food supplements (e.g., Alam et al 2016 ; Al Adham et al 2017 ; Leandro et al 2020 ; Ibrahim et al 2021 , 2022 ) as they contain abundant multifunctional bioactive compounds such as polysaccharides, carotenoids, polyphenolics, antioxidants, dietary fibers, polyunsaturated fatty acids, vitamins, and minerals (Devi et al 2011 ; Pereira 2020 ; Pradhan et al 2021 ; Semaida et al 2022 ). Several structurally diverse polysaccharides, such as alginates and fucoidan, found within the cell walls of brown seaweeds, are exploited for their powerful pharmaceutical and biomedical properties (Rashad and El-Chaghaby 2020 ; Rashedy et al 2021 ; Saeed et al 2021 ; Ismail et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

Samir

Hassan

Saber

et al. 2023

Environ Sci Pollut Res

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Doxorubicin (DOX) is a potent anticancer drug with adverse cardiotoxic effects. Alginates are multifunctional biopolymers and polyelectrolytes derived from the cell walls of brown seaweeds. They are nontoxic, biocompatible, and biodegradable, and hence, utilized in several biomedical and pharmaceutical applications. Here, we investigated the potential cardioprotective effect of thermally treated sodium alginate (TTSA), which was extracted and purified from the seaweed Sargassum aquifolium, in treating acute DOX cardiotoxicity and apoptotic pathways in rats. UV–visible spectroscopy, Fourier-transform infrared, and nuclear magnetic resonance (1H–NMR) spectroscopy techniques were used to characterize TTSA. CK-MB and AST levels in sera samples were determined. The expression levels of Erk-2 (MAPK-1) and iNOS genes were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression levels of Erk-2, anti-apoptotic p53, and caspase-3 were analyzed using western blotting and ELISA. For the in vivo studies, sixty rats were randomly divided equally into six groups and treated with DOX, followed by TTSA. We revealed that treatment with TTSA, which has low molecular weight and enhanced antioxidant properties, improved DOX-mediated cardiac dysfunction and alleviated DOX-induced myocardial apoptosis. Furthermore, TTSA exhibited a cardioprotective effect against DOX-induced cardiac toxicity, indicated by the increased expression of MAPK-1 (Erk2) and iNOS genes, which are implicated in the adaptive responses regulating DOX-induced myocardial damage. Moreover, TTSA significantly (p < 0.05) suppressed caspase-3 and upregulated anti-apoptotic protein p53 expression. TTSA also rebalanced the cardiomyocyte redox potential by significantly (p < 0.05) increasing the levels of endogenous antioxidant enzymes, including catalase and superoxide dismutase. Our findings suggest that TTSA, particularly at a dose of 400 mg/kg b.w., is a potential prophylactic supplement for treating acute DOX-linked cardiotoxicity.

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Characterization of Bioactive Components in Edible Algae

Abstract: From the origin of our planet, about 4 [...]

Cited by 19 publications

References 18 publications

Medicinal and Pharmaceutical Applications of Seaweeds

Medicinal and Pharmaceutical Applications of Seaweeds

Algae: A Robust Living Material Against Cancer

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

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