Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

Nagaoka, Tadahiro; Fukuda, Takayuki; Yoshida, Shinnosuke; Nishimura, Hirokazu; Yu, Dongwei; Kuroda, Shinya; Tanizawa, Katsuyuki; Kondo, Akihiko; Ueda, Mitsuharu; Yamada, Hidenori; Tada, Hayato; Seno, Masaharu

doi:10.1016/j.jconrel.2006.12.020

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…For example, L-protein (surface antigen of hepatitis B virus), having pre-S1 surface peptide ligand, is responsible for binding to the liver receptors. 77 To selectively target them to brain tumor, they were surface modified in light of the fact that human glioblastoma cells overexpress epidermal growth factor receptor (EGFR) in brain tumor. Therefore, in the hybrid BNCs, pre-S1 region was replaced with protein A and conjugated with anti-human EGFR antibody, which delivered the drug selectively to glioma cells in the brain tumor, sparing the normal glial cells.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

Mishra

Patel

Tiwari

2010

Nanomedicine: Nanotechnology, Biology and Medicine

640

312

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

Mishra

Patel

Tiwari

2010

Nanomedicine: Nanotechnology, Biology and Medicine

640

312

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“…To enhance the stability of the BNC, the density of cystein residues of the S domain of the protein needs to be minimized. Otherwise, the nanostructures aggregate due to random disulfide bridging when stored for a long period at 4°C (92).…”

Section: Drug Delivery and Targeting Strategies And Novel Anti-hbv Drmentioning

confidence: 99%

Drug Delivery Systems and Liver Targeting for the Improved Pharmacotherapy of the Hepatitis B Virus (HBV) Infection

et al. 2010

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In spite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection is still the most common cause of liver cirrhosis and hepatocellular carcinoma, with more than 400 million people chronically infected worldwide. Antiviral therapy with nucleos(t)ide analogues and/or immunomodulating peptides is the only option to control and prevent the progression of the disease in chronic hepatitis B (CHB)-infected patients. So far, the current antiviral monotherapy remains unsatisfactory because of the low efficacy and the development of drug resistance mutants. Moreover, viral rebound is frequently observed following therapy cessation, since covalent closed circular DNA (cccDNA) is not removed from hepatocytes by antiviral therapy. First, this review describes the current pharmacotherapy for the management of CHB and the new drug candidates being investigated. Then, the challenges in the development of drug delivery systems for the targeting of antiviral drugs to the liver parenchyma are discussed. Finally, perspectives in the design of a more efficient pharmacotherapy to eradicate the virus from the host are addressed.

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“…[17] Furthermore, miniemulsion provides the opportunity to finely tune particle size distribution while preparing emulsion with high solid content of polymers. [18][19][20] The crosslinking of polymer-containing nanodroplets formed by miniemulsion is a particularly attractive method to produce nanocarriers (Figure 1). Hollow nanocapsules can be prepared by a polyaddition or polycondensation reaction occurring at the droplets interface.…”

mentioning

confidence: 99%

Large‐Scale Preparation of Polymer Nanocarriers by High‐Pressure Microfluidization

Alkanawati

Wurm

Thérien-Aubin

et al. 2017

Macro Materials & Eng

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by dispersion, suspension emulsion, or miniemulsion polymerization, while the preparation of polymer nanocarriers made from preformed polymers usually occurs by coacervation methods such as salting out, [13] emulsification-diffusion, [14] nanoprecipitation, and supercritical fluid technology. [15,16] Among those different preparation techniques, miniemulsion is particularly attractive due to its ability to prepare nanocarriers from either mono mer or polymer while allowing for the efficient loading of large doses of therapeutic agents, which can be lipophilic and/or hydrophilic compounds. [17] Furthermore, miniemulsion provides the opportunity to finely tune particle size distribution while preparing emulsion with high solid content of polymers. [18][19][20] The crosslinking of polymer-containing nanodroplets formed by miniemulsion is a particularly attractive method to produce nanocarriers (Figure 1). Hollow nanocapsules can be prepared by a polyaddition or polycondensation reaction occurring at the droplets interface. [21] In order to prepare nanocarriers, the polymer is dissolved in a good solvent and emulsified with an immiscible nonsolvent forming the continuous phase. After the emulsification, a crosslinking agent, soluble in the continuous phase, is added to the emulsion and the poly addition or polycondensation reaction between the polymer and crosslinking agent occurs at the surface of the droplet. When the reaction kinetic is fast enough, a shell insoluble in both phases can be formed at the interface. [22] To control the size and size distribution of the nanocapsules prepared by the polyaddition/polycondensation reaction at the droplet interface, it is critical to control the preparation of the miniemulsion used as a precursor. The two main factors leading to the broadening of the size distribution of the nanodroplets during miniemulsion are (i) Ostwald ripening and (ii) coalescence of the droplets occurring through collision. The coalescence could be controlled by the addition of an appropriate surfactant, which provides electrostatic or steric stabilization thus preventing droplet coalescence. Ostwald ripening is affected by multiple factors such as droplet size, Laplace pressure, polydispersity, and solubility of the dispersed phase in the continuous phase. In general, Ostwald ripening could be limited by the addition of compounds increasing the osmotic pressure in the system. These chemicals need to be highly insoluble in the continuous phase but completely soluble in the Nanocapsules Polymer nanocarriers are used as transport modules in the design of the next generation of drug delivery technology. However, the applicability of nanocarrier-based technology depends strongly on our ability to precisely control and reproduce their synthesis on a large scale because their properties and performances are strongly dependent on their size and shape. Fundamental studies and practical applications of polymer nanocarriers are hampered by the difficulty of using the current methods to produce monodispersed ...

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Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

Cited by 17 publications

References 34 publications

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

Drug Delivery Systems and Liver Targeting for the Improved Pharmacotherapy of the Hepatitis B Virus (HBV) Infection

Large‐Scale Preparation of Polymer Nanocarriers by High‐Pressure Microfluidization

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