“…Like SA, AGP has also been reported to bind to Imatinib, thus negatively influencing its therapeutic activity in cancer patients ( Kremer et al, 1988; Gambacorti-Passerini et al, 2000; Fitos et al, 2006, 2012; Hegde et al, 2012 ). To investigate the effect of AGP in our system, adult S. mansoni couples were maintained in culture medium, which was supplemented with human AGP at a final concentration of 0.8 g/L, similar to that found in human plasma (0.5–1.4 g/L) ( Schultz and Arnold, 1990; Gambacorti-Passerini et al, 2000 ).…”