Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications

Cheng, Fan‐Tien; Su, Chia‐Hao; Yang, Yu; Yeh, Chen Sheng; Tsai, Chiau Yuang; Wu, Chao; Wu, Ming Ting; Shieh, Dar Bin

doi:10.1016/j.biomaterials.2004.03.016

Cited by 625 publications

(304 citation statements)

References 46 publications

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“…From XRD, the crystallite size has been estimated as 4.3 and 9.5 nm for sample A and sample B, respectively. Cheng et al, 2005 synthesized Fe 3 O 4 nanoparticles using Fe(II) and Fe(III) salt chemical coprecipitation with tetramethylammonium hydroxide (N(CH 3 ) 4 OH) in an aqueous solution which resulted in an iron oxide particles with 9 nm diameter in size. Their result is according to ours, when iron oxide nanoparticles were synthesized before alginate gelation.…”

Section: Resultsmentioning

confidence: 99%

“…Other than this, a large number of magnetic materials in bulk as well as in the form of nanoparticles have been exploited for a variety of medical applications. According to Cheng et al, 2005; the in vitro cytotoxicity test revealed that the magnetite particles exhibited excellent biocompatibility. Fe 3 O 4 nanoparticles are commonly produced via co-precipitation of Fe(II) and Fe(III) ions by a base, usually sodium hydroxide or aqueous ammonia (Kang et al, 1996;Hong et al, 1997;Fried et al, 2001) or they may be made by thermal decomposition of alkaline solution of Fe(III) chelate in the presence of hydrazine and by sonochemical decomposition of hydrolyzed Fe(II) salt followed by thermal treatment (Sapieszko et al, 1980;Vijayakumar et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Finotelli

Sampaio

Morales

et al. 2008

Braz. J. Chem. Eng.

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-Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Finotelli

Sampaio

Morales

et al. 2008

Braz. J. Chem. Eng.

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“…27 First, 1 M FeCl 3 ·6H 2 O and 2 M FeCl 2 ·4H 2 O solutions were prepared by dissolving iron salts in 2 M HCl solutions. Later, 10 ml of 1 M FeCl 3 solution was mixed with 2.5 ml of 2 M FeCl 2 solution in a flask.…”

Section: Fe 3 O 4 Nanoparticle and Gelma Synthesismentioning

confidence: 99%

Magnetically actuated cell-laden microscale hydrogels for probing strain-induced cell responses in three dimensions

Huang

Gao

et al. 2016

NPG Asia Mater

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Living cells respond to their mechanical microenvironments during development, healing, tissue remodeling and homeostasis attainment. However, this mechanosensitivity has not yet been established definitively for cells in three-dimensional (3D) culture environments, in part because of challenges associated with providing uniform and consistent 3D environments that can deliver a large range of physiological and pathophysiological strains to cells. Here, we report microscale magnetically actuated, cell-laden hydrogels (μMACs) for investigating the strain-induced cell response in 3D cultures. μMACs provide high-throughput arrays of defined 3D cellular microenvironments that undergo reversible, relatively homogeneous deformation following non-contact actuation under external magnetic fields. We present a technique that not only enables the application of these high strains (60%) to cells but also enables simplified microscopy of these specimens under tension. We apply the technique to reveal cellular strain-threshold and saturation behaviors that are substantially different from their 2D analogs, including spreading, proliferation, and differentiation. μMACs offer insights for mechanotransduction and may also provide a view of how cells respond to the extracellular matrix in a 3D manner.

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“…Magnetic measurement at 300 K using a superconducting quantum interference device (SQUID) magnetometer [10] shows that both SPIO NPs and MSNCs are superparamagnetic ( Figure 3). However, the paramagnetic strength of MSNCs is determined to be 4.0 emug −1 at 1.0T, which is smaller than SPIO NPs by a factor of ten.…”

mentioning

confidence: 99%