Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Mass Spectrometry Reviews

Shvartsburg

Afonso

et al. 2019

370

477

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values ( K 0 ) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E / N ; (ii) ion mobility does not measure molecular surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model; (iii) methods relying on calibration are empirical (and thus may provide method‐dependent results) only if the gas nature, temperature or E / N cannot match those of the primary method. Our analysis highlights the urgency of a community effort toward establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. © 2019 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc.

Section: Reporting Ion Mobility Measurementsmentioning

confidence: 99%

Recommendations for reporting ion mobility Mass Spectrometry measurements

Mass Spectrometry Reviews

Shvartsburg

Afonso

et al. 2019

370

477

“…Descriptions of the typical wave shapes have been published for the first-generation SYNAPT (Giles et al, 2004), and the SYNAPT G2/G2-S/G2-Si (Giles, Williams, & Campuzano, 2011) series. For home-made instruments (e.g., SLIM-based), specify the electrode dimensions, inter-surface gap, and all wave attributes (shape, height(s), velocity) (Hamid et al, 2018).…”

Section: Drift Tube Imsmentioning

confidence: 99%

Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements

Shvartsburg²,

Afonso³

et al. 2018

Preprint

Here we present a guide on ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties on mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N, (ii) ion mobility does not measure surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model, (iii) methods relying on calibration are empirical (and thus may provide method-dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort towards establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. <br><br><br>

“…Descriptions of the typical wave shapes have been published for the first-generation SYNAPT (Giles et al, 2004), and the SYNAPT G2/G2-S/G2-Si (Giles, Williams & Campuzano, 2011) series. For home-made instruments (e.g., SLIM-based), specify the electrode dimensions, inter-surface gap, and all wave attributes (shape, height(s), velocity,…) (Hamid et al, 2018).…”

Section: V212 Travelling Wave Imsmentioning

confidence: 99%

Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements

Shvartsburg²,

Afonso³

et al. 2018

Preprint

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K 0 ) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N; (ii) ion mobility does not measure molecular surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model; (iii) methods relying on calibration are empirical (and thus may provide method-dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort toward establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. #