Characterization of Antibiotic Resistance in Enterobacteriaceae From Agricultural Manure and Soil in Portugal

Amador, Paula; Duarte, Isabel; Costa, Rui; Fernandes, Rúben; Prudêncio, Cristina

doi:10.1097/ss.0000000000000222

Cited by 13 publications

(6 citation statements)

References 43 publications

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“…In contrast to tetracyclines, sulfonamide compounds do not sorb strongly to the soil, and have been detected in surface water, groundwater and soil pore water [70]. Nevertheless, these antibiotics and their resistance genes have been found in soil and manure [21,52,64,68,71,72]. Mutations in the chromosomal DHPS gene that codes for the inhibition of folic acid biosynthesis (folP) or the acquisition of an alternative DHPS gene (sul) are responsible for sulfonamide resistance [64,65].…”

Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

“…The sul genes occur in a wide range of bacterial species because they are frequently located on mobilizable plasmids and in mobile genetic elements, such as class 1 integrons and transposons [64,65,[67][68][69]. These elements carry multiple antibiotic resistance genes that are co-selected by sulphonamides [64,69,72]. The presence of sul genes in pig farms and cattle waste lagoons seems to be associated with the use of sulfonamide [30,73].…”

Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

115

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The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts of manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria are frequently detected in manure and manure-amended soils. This review explores the role of manure in the persistence and dissemination of ARGs in the environment, analyzes the procedures used to decrease antimicrobial resistance in manure and the potential impact of manure application in public health. We highlight that manure shows unique features as a hotspot for antimicrobial gene dissemination by horizontal transfer events: richness in nutrients, a high abundance and diversity of bacteria populations and antibiotic residues that may exert a selective pressure on bacteria and trigger gene mobilization; reduction methodologies are able to reduce the concentrations of some, but not all, antimicrobials and microorganisms. Conjugation events are often seen in the manure environment, even after composting. Antibiotic resistance is considered a growing threat to human, animal and environmental health. Therefore, it is crucial to reduce the amount of antimicrobials and the load of antimicrobial resistant bacteria that end up in soil.

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Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

115

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“…Social sustainability is a complex dimension of pig production [13]. The widespread use of antibiotics, and resulting residues and resistant bacteria in soil and food products, are a threat to human health [14,15]. The working environment may also pose a threat, exposing staff members to noise, increased risk of respiratory diseases, and injuries [16].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Mapping of Research on Sustainability Dimensions at Farm-level in Pig Production

et al. 2020

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We systematically mapped the scientific literature on the sustainability of pig production at farm-level. Sustainability was considered holistically, covering its economic, environmental, and social dimensions, each consisting of a broad range of different aspects that may contradict or reinforce each other. Literature published between January 2000 and March 2020 with a geographical focus on Europe, North America, Australia, and New Zealand was included. A standard template with predefined keywords was used to summarise aspects of each sustainability dimension covered in identified papers. We found that papers analysing environmental sustainability were more frequent than papers analysing economic or social sustainability. However, there are many different aspects within each dimension of sustainability, hampering comparisons between studies. In addition, each dimension of sustainability has many sides, making it difficult to compare different studies, and different dimensions and aspects may have complex interrelations. Our systematic literature review revealed that these interrelations are not well understood and that possible trade-offs or synergies between different aspects of sustainability dimensions remain unidentified. This systematic mapping of the current literature on farm-level sustainability in pig production can support a more informed discussion on knowledge gaps and help prioritise future research at farm-level to enhance sustainability in pig production.

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“…The discovery of penicillin in 1928 started the antibiotic era, and these compounds enjoyed great success in the treatment of bacterial infections. However, due to their extensive application and mainly their abuse and inappropriate uses, the effectiveness of these compounds was drastically reduced due to the increase in antibiotic resistance in bacteria with the emergence of strains that are resistant to all known antibiotics [ 27 , 28 ]. This problem was further compounded with the appearance of phytopathogenic bacteria that are resistant to copper, as is the case for some Pseudomonas and Xanthomonas species [ 29 , 30 ].…”

Section: A Look At the Pastmentioning

confidence: 99%

A Hundred Years of Bacteriophages: Can Phages Replace Antibiotics in Agriculture and Aquaculture?

et al. 2020

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Agriculture, together with aquaculture, supplies most of the foodstuffs required by the world human population to survive. Hence, bacterial diseases affecting either agricultural crops, fish, or shellfish not only cause large economic losses to producers but can even create food shortages, resulting in malnutrition, or even famine, in vulnerable populations. Years of antibiotic use in the prevention and the treatment of these infections have greatly contributed to the emergence and the proliferation of multidrug-resistant bacteria. This review addresses the urgent need for alternative strategies for the use of antibiotics, focusing on the use of bacteriophages (phages) as biocontrol agents. Phages are viruses that specifically infect bacteria; they are highly host-specific and represent an environmentally-friendly alternative to antibiotics to control and kill pathogenic bacteria. The information evaluated here highlights the effectiveness of phages in the control of numerous major pathogens that affect both agriculture and aquaculture, with special emphasis on scientific and technological aspects still requiring further development to establish phagotherapy as a real universal alternative to antibiotic treatment.

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Characterization of Antibiotic Resistance in Enterobacteriaceae From Agricultural Manure and Soil in Portugal

Cited by 13 publications

References 43 publications

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

A Systematic Mapping of Research on Sustainability Dimensions at Farm-level in Pig Production

A Hundred Years of Bacteriophages: Can Phages Replace Antibiotics in Agriculture and Aquaculture?

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