Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia

Totté, Philippe; YaYa, Aboubakar; Séry, Amadou; Wesonga, Hezron; Wade, Abel; Naessens, Jan; Niang, Mamadou; Thiaucourt, François

doi:10.1371/journal.pone.0057509

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…However, within the month following vaccination series B, WC-fed calves had a greater number of CD4 + CD62L − CD45RO + T cells as compared with CFC-fed calves. Previous studies showed an increase in CD45RO on CD4 + T cells after vaccinations in both young and adult cattle (Stabel and Robbe-Austerman, 2011;Totte et al, 2013). The increase in CD4 + CD62L − CD45RO + T cells after vaccination series B could be attributed to enhanced antigen presentation and lymphocyte activation capabilities in WC-fed calves when compared with CFC-fed calves.…”

Section: Discussionmentioning

confidence: 84%

Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response

Langel

Wark

Garst

et al. 2016

Journal of Dairy Science

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Vaccination contributes to improved herd health and production. Boosting immune development at a young age may have long-term effects by enhancing vaccine immune response and efficacy. In the bovine, colostrum is the sole source of maternal immunity, having a substantial effect on health status in the neonate. To date, colostral antibody concentration is used to evaluate colostrum quality. However, colostrum also contains proteins and cells, which may affect immune development and future responses to vaccines. To determine the effect of maternal colostral cells on immune development, 37 female Holstein and Jersey dairy calves were bottle-fed 4 quarts total of whole colostrum (WC) or cell-free colostrum (CFC) at birth. Calves were vaccinated with 2 series of multivalent vaccines. Series A consisted of vaccines given between 1 and 4mo of life. Series B consisted of vaccines given between 5 and 10mo of life. Calf peripheral blood samples were obtained before each vaccination series and monthly for 3mo after each vaccination series. Cellular blood parameters were determined by flow cytometry. Quantitative real-time PCR was used to determine cytokine gene expression in peripheral blood mononuclear cells before vaccination series B and once a month for 2mo after vaccination series B. Calves fed CFC had fewer numbers of B cells in mo 2 after vaccination series A when compared with WC-fed calves. Calves fed CFC had decreased gene expression levels of IL-2 in mo 1 and numbers of CD4(+)CD62L(+)CD45RO(-) and CD4(+)CD62L(+)CD45RO(+) T cells in mo 0 and 1 after vaccination series B as compared with WC-fed calves. Our findings indicate a greater response to vaccines up to 6 to 10mo post-WC feeding when compared with CFC. These data suggest that adoptive transfer of maternal colostral cells at birth has a long-term effect on development of the neonatal immune system.

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Section: Discussionmentioning

confidence: 84%

Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response

Langel

Wark

Garst

et al. 2016

Journal of Dairy Science

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“…Interestingly, lower Mmm -induced recall activation of CD4+ T lymphocytes was detected in draining lymph nodes of animals chronically infected (i.e., presence of Mmm -containing sequestra in the lungs) in comparison to animals showing complete recovery [ 26 ]. Also, we have recently reported the absence of measurable T-cell responses in cattle one month after immunization with the attenuated T1/44 vaccine strain of Mmm [ 45 ]. The T1/44 strain also produces the EPS form of galactan [ 46 ] which may therefore potentially contribute to its poor T-cell immunogenicity.…”

Section: Discussionmentioning

confidence: 99%

Free exopolysaccharide from Mycoplasma mycoides subsp. mycoides possesses anti-inflammatory properties

Totté

Puech

Rodrigues

et al. 2015

Vet Res

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In this study we explored the immunomodulatory properties of highly purified free galactan, the soluble exopolysaccharide secreted by Mycoplasma mycoides subsp. mycoides (Mmm). Galactan was shown to bind to TLR2 but not TLR4 using HEK293 reporter cells and to induce the production of the anti-inflammatory cytokine IL-10 in bovine macrophages, whereas low IL-12p40 and no TNF-α, both pro-inflammatory cytokines, were induced in these cells. In addition, pre-treatment of macrophages with galactan substantially reduced lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines TNF- and IL-12p40 while increasing LPS-induced secretion of immunosuppressive IL-10. Also, galactan did not activate naïve lymphocytes and induced only low production of the Th1 cytokine IFN-γ in Mmm-experienced lymphocytes. Finally, galactan triggered weak recall proliferation of CD4+ T lymphocytes from contagious bovine pleuropneumonia-infected animals despite having a positive effect on the expression of co-stimulatory molecules on macrophages. All together, these results suggest that galactan possesses anti-inflammatory properties and potentially provides Mmm with a mechanism to evade host innate and adaptive cell-mediated immune responses.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-015-0252-6) contains supplementary material, which is available to authorized users.

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“…44 As far as CBPP is concerned, helper T cells seem to play a primary role during the early stages of Mmm infection, greatly contributing to the production of interferon-g (IFN-g), the latter being considered protective during CBPP. 23,24,46,106,107 In contrast, depletion of CD4 þ lymphocytes did not affect the clinical outcome, the pathology, the humoral immune response, or the serum level of IFN-g after Mmm experimental infection, 89 thus raising further questions about the real significance of helper T cells in the pathogenesis of CBPP. Likewise, data about the humoral immune response after Mmm infection are few and somewhat conflicting.…”

Section: Immune-mediated Mechanisms In the Pathogenesis Of Cbppmentioning

confidence: 97%

Contagious Bovine Pleuropneumonia: A Comprehensive Overview

et al. 2020

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Contagious bovine pleuropneumonia (CBPP) is a respiratory disease of cattle that is listed as notifiable by the World Organization for Animal Health. It is endemic in sub-Saharan Africa and causes important productivity losses due to the high mortality and morbidity rates. CBPP is caused by Mycoplasma mycoides subsp. mycoides ( Mmm) and is characterized by severe fibrinous bronchopneumonia and pleural effusion during the acute to subacute stages and by pulmonary sequestra in chronic cases. Additional lesions can be detected in the kidneys and in the carpal and tarsal joints of calves. Mmm infection occurs through the inhalation of infected aerosol droplets. After the colonization of bronchioles and alveoli, Mmm invades blood and lymphatic vessels and causes vasculitis. Moreover, Mmm can be occasionally demonstrated in blood and in a variety of other tissues. In the lung, Mmm antigen is commonly detected on bronchiolar and alveolar epithelial cells, in lung phagocytic cells, within the wall of blood and lymphatic vessels, inside necrotic areas, and within tertiary lymphoid follicles. Mmm antigen can also be present in the cytoplasm of macrophages within lymph node sinuses, in the germinal center of lymphoid follicles, in glomerular endothelial cells, and in renal tubules. A complete pathological examination is of great value for a rapid presumptive diagnosis, but laboratory investigations are mandatory for definitive diagnosis. The purpose of this review is to describe the main features of CBPP including the causative agent, history, geographic distribution, epidemiology, clinical course, diagnosis, and control. A special focus is placed on gross and microscopic lesions in order to familiarize veterinarians with the pathology and pathogenesis of CBPP.

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Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia

Cited by 10 publications

References 19 publications

Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response

Effect of feeding whole compared with cell-free colostrum on calf immune status: Vaccination response

Free exopolysaccharide from Mycoplasma mycoides subsp. mycoides possesses anti-inflammatory properties

Contagious Bovine Pleuropneumonia: A Comprehensive Overview

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