Characterization of an Optical Device with an Array of Blue Light Emitting Diodes LEDS for Treatment of Neonatal Jaundice.

Sebbe, Priscilla Fróes; Villaverde, Antônio Balbin; Nicolau, Renata Amadei; Barbosa, Ana Maria; Veissid, Nelson; Wetter, Niklaus Ursus; Frejlich, Jaime

doi:10.1063/1.2926936

Cited by 2 publications

(1 citation statement)

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“…For this reason, a new phototherapy device for neonatal jaundice treatment was developed by our research group, using as a light source an array of LEDs emitting in the blue region of the spectrum. The unit was constructed in agreement to the international norm IEC 60601-2-50, which establishes rules on safety and performance of phototherapy equipments for treatment of neonatal jaundice [20].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a novel LEDs device prototype for neonatal jaundice and its comparison with fluorescent lamps sources: Photpublisher-idapy treatment of hyperbilirubinemia in Wistar rats

et al. 2009

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This work describes experimental tests done using the LED-therapy equipment developed for neonatal jaundice treatment. Neonatal photpublisher-idapy consists in the irradiation of jaundice new-born with a high intensity light, in the spectral range of 400–500 nm, in order to promote the photochemical transformation of the bilirubin molecules in the areas exposed to the light. A convenient light source for jaundice treatment can be obtained employing blue LEDs, which are simple devices that present low cost, small heating production, narrow spectral band and long life-time. Equipment using an array with 88 blue LEDs (emission peak at 472 nm with 50 nm bandwidth) was constructed, optically characterized and then validated in comparison with a commercial equipment of photpublisher-idapy, i.e., the Fluorescent Conventional. For the device validation, experiments were undertaken employing male Wistar rats, to which the hyperbilirubinemia was induced by the obstruction of the billi duct. Using the LED-therapy equipment, it was obtained a reduction by 78% of the indirect bilirubin concentration against only 39% referent to the commercial Fluorescent Conventional, both for 8 h of treatment. For a period of 24 h, the reduction was 92% and 76%, respectively. Thus, the novel LED-therapy equipment was more efficient for photodegradation of the bilirubin molecules in animal model, when compared with the Conventional equipment. The novel prototype present requisites to be applied in clinical treatments, such as a large and uniform area of irradiation, efficient wavelength emission for jaundice treatment, high spectral irradiance, simplicity and low values of weight, heating and cost. Therefore, the new device is candidate to systematic applications in photpublisher-idapy treatments.

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Section: Introductionmentioning

confidence: 99%

Characterization of a novel LEDs device prototype for neonatal jaundice and its comparison with fluorescent lamps sources: Photpublisher-idapy treatment of hyperbilirubinemia in Wistar rats

et al. 2009

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Evanescent field: A potential light-tool for theranostics application

Polley

Singh

Giri

et al. 2014

Review of Scientific Instruments

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A noninvasive or minimally invasive optical approach for theranostics, which would reinforce diagnosis, treatment, and preferably guidance simultaneously, is considered to be major challenge in biomedical instrument design. In the present work, we have developed an evanescent field-based fiber optic strategy for the potential theranostics application in hyperbilirubinemia, an increased concentration of bilirubin in the blood and is a potential cause of permanent brain damage or even death in newborn babies. Potential problem of bilirubin deposition on the hydroxylated fiber surface at physiological pH (7.4), that masks the sensing efficacy and extraction of information of the pigment level, has also been addressed. Removal of bilirubin in a blood-phantom (hemoglobin and human serum albumin) solution from an enhanced level of 77 μM/l (human jaundice >50 μM/l) to ~30 μM/l (normal level ~25 μM/l in human) using our strategy has been successfully demonstrated. In a model experiment using chromatography paper as a mimic of biological membrane, we have shown efficient degradation of the bilirubin under continuous monitoring for guidance of immediate/future course of action.

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Characterization of an Optical Device with an Array of Blue Light Emitting Diodes LEDS for Treatment of Neonatal Jaundice.

Cited by 2 publications

References 4 publications

Characterization of a novel LEDs device prototype for neonatal jaundice and its comparison with fluorescent lamps sources: Photpublisher-idapy treatment of hyperbilirubinemia in Wistar rats

Characterization of a novel LEDs device prototype for neonatal jaundice and its comparison with fluorescent lamps sources: Photpublisher-idapy treatment of hyperbilirubinemia in Wistar rats

Evanescent field: A potential light-tool for theranostics application

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