Characterization of an Activated Human ros Gene

Abstract

A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

Evolution, Expression, and Chromosomal Location of a Novel Receptor Tyrosine Kinase Gene, eph

“…In transformed cells, several alterations of receptor tyrosine kinases have been found both in quality (2,4,6,12,42,60,62,71,75) and in quantity (14,22,37,39,69,75). We have found that certain neoplastic cells overexpress eph mRNAs without changes in their size.…”

Pre-clinical modelling of ROS1+ non-small cell lung cancer

“…The presence of ROS1 rearrangements was initially discovered in 1987 by Birchmeier et al, when abundant ROS1 expression was reported in the glioblasoma U-118 MG cell line [10,11]. In parallel, the oncogenic transformation of chicken embryo fibroblasts by avian sarcoma virus UR2 (v-ros) containing a ROS1 isoform lacking the sequence coding for the extracellular domain was observed [12].…”

Counter-regulatory renin-angiotensin system in hypertension: Review and update in the era of COVID-19 pandemic

“…The binding receptor for Ang (1-7) is Mas receptor (MasR), a bioactive peptide encoded by the MAS1 gene. In the 1980s, MAS1 was initially identified as a human oncogene based on its ability to induce tumorigenicity of NIH 3T3 cells in nude mice [65] , [66] . MasR belongs to a member of G protein-coupled receptors (GPCRs) with a predicted seven transmembrane segment structure.…”