2011
DOI: 10.1590/s0100-879x2010007500144
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Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population

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Cited by 8 publications
(5 citation statements)
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References 32 publications
(37 reference statements)
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“…Thus, the --DANE deletion is new as it does not match any published a 0 -globin deletions. This novel deletion adds to recent discoveries of new a 0 deletions, where MLPA has emerged as a widely used and easily accessible method for the detection of unknown deletions and localizing breakpoints (12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 97%
“…Thus, the --DANE deletion is new as it does not match any published a 0 -globin deletions. This novel deletion adds to recent discoveries of new a 0 deletions, where MLPA has emerged as a widely used and easily accessible method for the detection of unknown deletions and localizing breakpoints (12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 97%
“…MLPA is a hybridization-based method that has been used for many years to screen deletions and duplications. For this reason, the MLPA method is often used to elucidate the genetic basis of alpha thalassemias (24). The advantages of the MLPA method over other methods in the genetic basis of alpha thalassemia have been reported in the studies of Yüreğir and Colosimo et al (13,25).…”
Section: Discussionmentioning
confidence: 99%
“…Previously PCR based methods such as RDB, multiplex PCR, quantitative real-time PCR were used extensively as diagnostic tools [14]. As MLPA is a convenient alternative method for detecting deletions it has recently been a compelling choice for mutation analysis of a-thalassemias [15].…”
Section: Discussionmentioning
confidence: 99%