Characterization of alkaline and acid phosphatases from skeletal muscles of young and old rats

Safadi, A.; Livne, Erella; Reznick, Abraham Z.

doi:10.1016/s0167-4943(96)00751-0

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Western blot analysis revealed that rDUSP14 exists as the mixture of the monomer and the dimer in nonreducing conditions and a reducing environment disrupted its dimeric state, suggesting that cysteine bonds play a role in the dimer formation of rDUSP14. In recent studies, it was shown that NSF is active in both the monomeric and dimeric states, in contrast to a homodimeric enzyme ALP that is active only in the dimeric state 14,17,18 . These results suggest that the switch between the dimer and the monomer contributes to a potential self‐regulation mechanism in the function of NSF (DUSP14), although the minute mechanism is not known.…”

Section: Discussionmentioning

confidence: 99%

Novel function of DUSP14/MKP6 (dual specific phosphatase 14) as a nonspecific regulatory molecule for delayed-type hypersensitivity

Nakano¹

2007

Br J Dermatol

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Section: Discussionmentioning

confidence: 99%

Novel function of DUSP14/MKP6 (dual specific phosphatase 14) as a nonspecific regulatory molecule for delayed-type hypersensitivity

Nakano¹

2007

Br J Dermatol

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“…This phenomenon has been termed sarcopenia of old age,1 and the reasons for these age‐related changes in skeletal muscles are multifactorial and include changes in the muscle apparatus itself, changes in the neural system and stimuli, and the influence of external environmental factors 2. Among the changes observed were alterations in enzymatic activity3 and some morphologic changes 4. Immobilization of muscles of old animals can be used to study the muscle response to trauma and stress 5…”

Section: Introductionmentioning

confidence: 99%

Capacity for Recovery and Possible Mechanisms in Immobilization Atrophy of Young and Old Animals

Zarzhevsky¹,

Menashe²,

Carmeli

et al. 2001

Annals of the New York Academy of Sciences

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The effect of limb immobilization on muscle wasting and recovery of young and old rats was studied. Limb immobilization caused rapid and pronounced muscle weight loss, which was overcome efficiently in the muscles of young animals. However, muscles of old animals did not recover as well, indicating that muscle turnover (degradation and synthesis of proteins) is slower in old muscles than in young ones. The mechanisms of muscle wasting due to immobilization may involve two stages, the fast phase employing calciumdependent proteolysis and the slower phase recruiting the lysosomal and ubiquitin-proteosome systems. The slow phase most probably involves the penetration of white cells between the muscle fibers and involves the secretion of cytokines that mediate a cascade of intracellular events, which culminates in muscle protein degradation. Thus, it was shown in our study and in other similar reports that through the influence of TNF-α α α α and an increase in oxidative stress, there is marked activation of transcription factor NF-κ κ κ κB, which in turn induces many proteins to carry the signals that eventually result in protein breakdown. Because protein turnover was shown to slow down with age, it will be of great interest to study these events in aging muscles and to try to ascertain the specific events that make protein breakdown in aged muscles different from that in young ones.

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“…ACP activities have been shown to change considerably both in muscles of immobilized limbs and in aging 6,7. The purpose of this report was to study the effects of four weeks of hindlimb immobilization on ACP activity of old rats in comparison with the profile obtained after similar treatment in young rats.…”

mentioning

confidence: 98%

Mechanisms in Muscle Atrophy in Immobilization and Aging

Bar-Shai

Carmeli

Coleman

et al. 2004

Annals of the New York Academy of Sciences

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Characterization of alkaline and acid phosphatases from skeletal muscles of young and old rats

Cited by 9 publications

References 18 publications

Novel function of DUSP14/MKP6 (dual specific phosphatase 14) as a nonspecific regulatory molecule for delayed-type hypersensitivity

Novel function of DUSP14/MKP6 (dual specific phosphatase 14) as a nonspecific regulatory molecule for delayed-type hypersensitivity

Capacity for Recovery and Possible Mechanisms in Immobilization Atrophy of Young and Old Animals

Mechanisms in Muscle Atrophy in Immobilization and Aging

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