Characterization of age-related changes in natural killer cells during primary influenza infection in mice

Nogusa, Shoko; Ritz, Barry W.; Kassim, Sadik H.; Jennings, Stephen R.; Gardner, Elizabeth M.

doi:10.1016/j.mad.2008.01.003

Cited by 101 publications

(99 citation statements)

References 15 publications

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“…However, previous studies indicate that NK cells may play protective or deleterious roles during IAV infection depending on the infecting virus doses (22). Therefore, we further investigated whether NK cells play a similar protective role in 129 mice during a low-dose PR8 infection.…”

Section: Nk Cells Are Not Protective Against Low-dose Pr8 Infectionmentioning

confidence: 94%

“…The roles that NK cells play during influenza virus infection are intricate. Several studies highlight the pivotal role of NK cells in the control of IAV infection in that defects in NK cell activity or depletion of NK cells result in delayed viral clearance and increased morbidity and mortality (21)(22)(23). However, there are also examples in which NK cells exacerbate morbidity and pathology during lethal dose influenza virus infection in mice (24,25), which indicate that NK cells may play dual roles during influenza virus infection in mice, conferring beneficial or deleterious function depending on the viral dose.…”

mentioning

confidence: 99%

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Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

Zhou

Wang

et al. 2016

The Journal of Immunology

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It is generally unclear what roles NK cells play during influenza virus infection with regard to different host genetic backgrounds. In this study, we show that in six inbred mouse strains, NK cells play an important protective role only in 129 mice during high-dose influenza A H1N1 virus infection. Swift and strong NK cell responses efficiently control early pulmonary viral replication in 129 mice, providing survival privilege. In addition, we identified that early activation of TLRs and RIG-I signaling in 129 mice resulted in quick production of type 1 IFNs and inflammatory cytokines, which are important reasons for the swift kinetics of NK cell responses post influenza virus infection. Thus, under different microenvironments, NK cells play differential roles against viral infections. The kinetics and magnitude of NK cell responses correlate with the distinct roles that NK cells play against influenza virus infections. Thus, our works further our understandings about the complex role of NK cells during influenza virus infection.

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Section: Nk Cells Are Not Protective Against Low-dose Pr8 Infectionmentioning

confidence: 94%

mentioning

confidence: 99%

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

Zhou

Wang

et al. 2016

The Journal of Immunology

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“…Patients with severe influenza infection were shown to have diminished NK cells in peripheral blood and an almost complete absence of pulmonary NK cells (40,79). In addition, during influenza infection, the decrease in NK cell activity also was demonstrated in mice (24,37,61). These data suggest that influenza virus directly target NK cells as part of its immunoevasion strategies.…”

mentioning

confidence: 90%

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

Mao

Liu

et al. 2010

J Virol

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“…A consensus is that there is a decrease in the immature, cytokine-producing (CD56 1 ) NK cells and a proportional increase in the mature, cytotoxic NK cells; however, both their functions are diminished with age. Lastly, there is evidence of the inability of aged NK cells to migrate to the inflamed sites during infection and reports of altered NK cell repertoire [28,[38][39][40][41]. Overall, the vital role of NK cells in preventing oncogenesis and viral pathogenesis seems to deteriorate with age.…”

Section: Natural Killer (Nk) Cellsmentioning

confidence: 99%

Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing

Nikolich‐Žugich

Davies

2017

Clinical and Experimental Immunology

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SummaryAgeing of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of ageing involves dissociating the effects of ageing on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of study, as it has the power to dissociate the age of the cell and the age of the microenvironment into which the cell resides or is migrating. So far, however, it has been used sparingly to study immune ageing. Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation. We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis. We found no systemic bias in retention or acceptance of neutrophils, macrophages, dendritic cells or natural killer cells with ageing in primary and secondary lymphoid organs. We conclude that these four innate immune cell types migrate to and populate lymphoid organs (peripheral lymph nodes, spleen and bone marrow), regardless of their own age and of the age of lymphoid organs.

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Characterization of age-related changes in natural killer cells during primary influenza infection in mice

Cited by 101 publications

References 15 publications

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing

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