Characterization of age- and location-associated variations in the composition of articular cartilage from the equine metacarpophalangeal joint

Macdonald, Melissa; Tesch, Anthony M.; Benton, Hilary P.; Willits, Neil H.

doi:10.1016/s0737-0806(02)70208-6

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…Full-thickness articular cartilage was dissected from the metacarpophalangeal and metatarsophalangeal joints of fresh equine cadavers, as previously described 25 . Cartilage was harvested from 18 horses between the ages of 1 and 8 years that died or were euthanized for problems unrelated to the musculoskeletal system.…”

Section: Tissue Collectionmentioning

confidence: 99%

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Endogenously produced adenosine regulates articular cartilage matrix homeostasis: enzymatic depletion of adenosine stimulates matrix degradation

Tesch

Macdonald

Kollias-Baker

et al. 2004

Osteoarthritis and Cartilage

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Section: Tissue Collectionmentioning

confidence: 99%

“…Chondrocytes were freed from the extracellular matrix by use of 3-step enzymatic digestion, as previously described 25 . Following digestion, undigested matrix was removed by passing the digest through a 70-µm cell strainer.…”

Section: Monolayer Viability Assaymentioning

confidence: 99%

Endogenously produced adenosine regulates articular cartilage matrix homeostasis: enzymatic depletion of adenosine stimulates matrix degradation

Tesch

Macdonald

Kollias-Baker

et al. 2004

Osteoarthritis and Cartilage

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“…They concluded that the functional adaptation of articular cartilage to mechanical loading occurs during the first 5 months postpartum, and that a certain amount of exercise is required to sustain this adaptation. Joints of horses less than 2 years of age had significantly higher cell numbers, total collagen and DNA content, and lower PG content, relative to mature horses ranging in age from 2 to 20 years old 108 . No significant difference in these measurements was found within the mature age groups.…”

Section: Agementioning

confidence: 85%

Equine osteoarthritis: a brief review of the disease and its causes

Schlueter

Orth

2004

Equine Comp. Exerc. Physiol.

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Degenerative joint diseases, such as osteoarthritis, adversely impact the health of the equine athlete as well as the economics of the equine industry. Our understanding of the aetiology of osteoarthritis, although not nearly exhaustive, has increased substantially in recent years. Molecules, including cytokines, inflammatory mediators, and metalloproteinases, have been identified and associated with the progression of joint disease. Several factors, including trauma to the joint, immobilization, conformation, shoeing, and ageing, have been linked with osteoarthritis. Our continued efforts into elucidating critical biological mediators and risk factors, coupled with better chondroprotective therapies and diagnostic tools, should facilitate our ability to maintain the skeletal health of the equine athlete

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“…chondrocytes, bone cells) respond to mechanical forces and remodel the extracellular matrix to withstand the prevailing levels of stress (Urban 1994;Ehrlich and Lanyon 2002). Therefore, in loadbearing areas of cartilage in normal joints, the matrix is thicker, has a higher proteoglycan concentration and is mechanically stronger than nonloadbearing regions of the same joint (MacDonald et al 2002). In contrast, immobilisation or reduced joint loading can lead to cartilage loss.…”

Section: Editorialmentioning

confidence: 99%