Characterization of a Variant of the SCC<i>mec</i>Element in a Bloodstream Isolate of<i>Staphylococcus intermedius</i>

Campanile, Floriana; Bongiorno, Dafne; Borbone, Sonia; Venditti, Mario; Giannella, Maddalena; Franchi, Cristiana; Stefani, Stefania

doi:10.1089/mdr.2006.9991

Cited by 43 publications

(31 citation statements)

References 22 publications

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“…18 Staphylococcus pseudintermedius is occasionally isolated from humans, and zoonotic transfer from dogs has been implicated. 6,12,22,23 There are currently no recommendations for interpretation of oxacillin susceptibility tests performed on human isolates of coagulase-positive staphylococci other than S. aureus. 8 However, the Clinical and Laboratory Standards Institute (CLSI; formerly National Committee for Clinical Laboratory Standards) recently recommended that oxacillin susceptibility of S. pseudintermedius and other veterinary isolates of coagulase-positive staphylococci be determined using breakpoints equivalent to those recommended for human and veterinary isolates of S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Susceptibility Test Breakpoints Used to Predict mecA-Mediated Resistance in Staphylococcus Pseudintevmedius Isolated from Dogs

et al. 2009

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Abstract. Clinical and Laboratory Standards Institute interpretive breakpoints for in vitro susceptibility tests that predict mecA-mediated oxacillin resistance in Staphylococcus pseudintermedius isolates from animals have been changed twice in the past decade. Moreover, there are no counterpart recommendations for human isolates of S. pseudintermedius. Individual medical and veterinary laboratories variably use interpretive breakpoints identical to those recommended for use with Staphylococcus aureus or identical to those recommended for use with coagulase-negative staphylococci. The purpose of the current study was to examine correlations between oxacillin disk diffusion, oxacillin gradient diffusion, oxacillin microbroth dilution, and cefoxitin disk diffusion tests used to predict mecA-mediated resistance in S. pseudintermedius and to retrospectively estimate, from disk diffusion zone diameter measurements, the prevalence and rate of increase of oxacillin resistance among canine S. pseudintermedius isolates submitted to a veterinary teaching hospital laboratory. Oxacillin disk diffusion zone diameters of #17 mm and oxacillin minimum inhibitory concentrations of $0.5 mg/ml were highly correlated with detection of mecA in canine S. pseudintermedius isolates by polymerase chain reaction. MecA-mediated resistance among S. pseudintermedius isolates from dogs increased from less than 5% in 2001 to near 30% in 2007. More than 90% of the methicillin-resistant S. pseudintermedius isolates in 2006 and 2007 were also resistant to representatives of $4 additional antimicrobial drug classes. Cefoxitin disk diffusion with the resistance breakpoint set at #24 mm significantly underestimated the presence of mecA in S. pseudintermedius.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Susceptibility Test Breakpoints Used to Predict mecA-Mediated Resistance in Staphylococcus Pseudintevmedius Isolated from Dogs

et al. 2009

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“…Also, nasal carriage rates of S. pseudintermedius were higher among owners with dogs suffering from deep pyoderma, although this has been shown to be a temporary colonization (Guardabassi et al, 2004;Frank et al, 2009). Regarding MRSP strains, the recognition of carriage among humans in contact with dogs was lower as well as that of sporadic human infections (Gerstadt et al, 1999, Campanile et al, 2007, Kempker et al, 2009, Stegmann et al, 2010.…”

Section: Zoonotic Implicationsmentioning

confidence: 97%

Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials

Papadogiannakis

Velonakis

Vatopoulos

2018

J Hellenic Vet Med Soc

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ABSTRACT. Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as an important pathogen in the dog over the past 10 years with an ever increasing incidence worldwide. This review focuses mainly on the epidemiology and detection of MRSP, emphasizing on the interpretation and pitfalls of screening laboratory tests and antimicrobial susceptibility tests. Risk factors for colonization and infection with MRSP and molecular analysis of the dominant clonal lineages are also described. The zoonotic potential and worldwide epidemiology of multidrug resistant Staphylococcus pseudintermedius (MDRSP) are presented. Finally, control options for the colonization of healthy dogs as well as infection by MRSP and MDRSP are described emphasizing on the indications for bacterial culture and susceptibility testing and the principles of topical therapy which may prove to be the sole effective treatment in several canine pyoderma cases.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, HA-MRSA strains with CA-MRSA features have tended to increase worldwide (Campanile et al, 2009;Nichol et al, 2011). Additionally, large-scale surveillance has shown that the antimicrobial resistance of both HA-MRSA and CA-MRSA strains has decreased in recent years (Campanile et al, 2009;Landrum et al, 2012). Many reports presenting results of MRSA isolated from several hospitals over a short period have been published; however, studies on the long-term surveillance for MRSA are extremely limited (Campanile et al, 2009;Nichol et al, 2011;Takata et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, large-scale surveillance has shown that the antimicrobial resistance of both HA-MRSA and CA-MRSA strains has decreased in recent years (Campanile et al, 2009;Landrum et al, 2012). Many reports presenting results of MRSA isolated from several hospitals over a short period have been published; however, studies on the long-term surveillance for MRSA are extremely limited (Campanile et al, 2009;Nichol et al, 2011;Takata et al, 2012). As such, long-term surveillance targeting a single hospital would be more detailed and show an accurate transition of MRSA, because it is possible to more consistently investigate the same conditions.…”

Section: Introductionmentioning

confidence: 99%

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Increase in SCCmec type IV strains affects trends in antibiograms of meticillin-resistant Staphylococcus aureus at a tertiary-care hospital

Ito

Nakaminami

Fujii

et al. 2015

Journal of Medical Microbiology

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The prevalence of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) strains has become a serious problem worldwide. The aim of this study was to investigate the annual transitions of MRSA strains with the CA-MRSA feature, which were identified as SCCmec type IV or V, in a hospital setting in Japan. Between 2005 and 2012, MRSA strains were collected from a tertiary-care hospital in Tokyo, Japan, and SCCmec typing, detection of the virulence factors and antimicrobial susceptibility testing were conducted. The rate of detection of type II SCCmec, which is found mainly in healthcare-associated MRSA, significantly decreased from 90.0 (2005)(2006) [2005][2006] to 2.1 % (2011-2012) (P,0.01). The resistance rates of cefotaxime, levofloxacin, clarithromycin and minocycline decreased every year. The resistance rates of these antimicrobial agents for the SCCmec type IV or V strains were significantly lower than those for the SCCmec type I or II strains (P,0.01, respectively). Therefore, these results suggest that the annual transitions of the virulence factors and antibiograms in MRSA are closely related to the increase of SCCmec type IV/V strains.

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Characterization of a Variant of the SCCmecElement in a Bloodstream Isolate ofStaphylococcus intermedius

Cited by 43 publications

References 22 publications

Evaluation of Susceptibility Test Breakpoints Used to Predict mecA-Mediated Resistance in Staphylococcus Pseudintevmedius Isolated from Dogs

Evaluation of Susceptibility Test Breakpoints Used to Predict mecA-Mediated Resistance in Staphylococcus Pseudintevmedius Isolated from Dogs

Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials

Increase in SCCmec type IV strains affects trends in antibiograms of meticillin-resistant Staphylococcus aureus at a tertiary-care hospital

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