Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications

Hoang, Ngoc Ha; Lim, Chaemin; Sim, Taehoon; Lee, Eun Seong; Youn, Yu Seok; Kim, Dongin; Oh, Kyung Taek

doi:10.1007/s00289-016-1791-3

Cited by 10 publications

(23 citation statements)

References 34 publications

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“…The triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than the free DOX [72].…”

Section: Polymer Micellesmentioning

confidence: 95%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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“…The triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than the free DOX [72].…”

Section: Polymer Micellesmentioning

confidence: 95%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…Based on these results, the loading capacity of DTBM for DTX is shown to be approximately 7.4 wt%. High DTX loading capacity in the micelles may be due to the hydrophobic PLA block that enabled the physical entrapment of hydrophobic drug in polymeric micelles by hydrophobic interaction between the drug molecule and the hydrophobic core of micelles (Shuai et al., 2004 ; Gao et al., 2012 ; Zhang et al., 2014 ; Hoang et al., 2017a ; Qi et al., 2017 ). DTBM prepared with 10% DTX loading exhibited particles of 125 nm in size with a spherical structure and narrow size distribution in DW ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Cell Counting Kit-8 (CCK-8) was purchased from Dojindo Molecular Technologies, Inc. (Rockville, MD). PEG–PLA–PEG triblock copolymers were synthesized using procedures described previously (Hoang et al., 2016 , 2017b ; Song et al., 2016 ). Detailed synthesis and characterization of PEG–PLA–PEG are described in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…In previous reports, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) was developed for tumor-targeted drug delivery (Song et al., 2016 ; Hoang et al., 2017a , b ). As a biocompatible water-soluble polymer, PEG has widely been utilized as a hydrophilic block because of its outstanding water solubility, chain mobility, nontoxicity, and non-immunogenicity (Yamaoka et al., 1994 ).…”

Section: Introductionmentioning

confidence: 99%

“…The triblock copolymer was synthesized by Steglich esterification and showed promising properties including high stability, high drug loading efficiency, and successful reconstitution, compared to PEG–PLA diblock copolymer (Song et al., 2016 ). In addition, PEG–PLA–PEG showed potential as an anticancer nanomedicine for metastatic breast cancer by tumor-targeted drug delivery with high therapeutic efficacy (Hoang et al., 2017a , b ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

et al. 2018

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Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150 nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

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Polyamide-based pH and temperature-responsive hydrogels: Synthesis and physicochemical characterization

Nguyen

Thambi

et al. 2018

J Polym Res

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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications

Cited by 10 publications

References 34 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Development of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

Polyamide-based pH and temperature-responsive hydrogels: Synthesis and physicochemical characterization

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