Characterization of a Recombinant<i>Yersinia enterocolitica</i>Lipoprotein; Implications for its Role in Autoimmune Response against Thyrotropin Receptor

Gangi, Eryn; Kapatral, Vinayak; El-Idrissi, Mohammed El Azami; Martinez, Osvaldo; Prabhakar, Bellur S.

doi:10.1080/08916930410001728074

Cited by 12 publications

(3 citation statements)

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“…Although there are a number of known bacterial triggers for development of reactive arthritis, the precise mechanism of the pathologic host response is unknown. Possibilities include an HLA-B27 autoantigen, cellular uptake of causative organisms, toll-like receptors, and chemokine involvement [19]. Graves’ disease has been associated with a variety of infectious agents, including Yersinia enterocolitica , which is also one of the bacteria known to cause reactive arthritis [20].…”

Section: Discussionmentioning

confidence: 99%

Concurrent reactive arthritis, Graves' disease, and warm autoimmune hemolytic anemia: a case report

Chiang

Packer

2009

Cases J

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Warm antibody autoimmune hemolytic anemia is due to the presence of warm agglutinins that react with protein antigens on the surface of red blood cells causing premature destruction of circulating red blood cells. We report the first case of concurrent reactive arthritis, Graves’ disease, and autoimmune hemolytic anemia. A 40-year-old man with reactive arthritis, Graves’ disease, type 2 diabetes mellitus, mitral valve prolapse, and Gilbert’s disease presented with a one month history of jaundice, fatigue, and black stools. After diagnosis of warm autoimmune hemolytic anemia, the patient was started on prednisone 1 mg/kg with rapid improvement in his anemia and jaundice. Our subject’s mother and possibly his maternal grandmother also had autoimmune hemolytic anemia, which raises the possibility of hereditary autoimmune hemolytic anemia, a rarely reported condition.

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Section: Discussionmentioning

confidence: 99%

Concurrent reactive arthritis, Graves' disease, and warm autoimmune hemolytic anemia: a case report

Chiang

Packer

2009

Cases J

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“…В Израиле, где распространенность иерсиниозов меньше, выявлено 45% серопозитивных лиц к Y. enterocolitica среди обследованных с тиреопатиями и ни одного из 77 здоровых [3]. Последующие исследования показали, что рТТГ и некоторые белки наружной мембраны Y. enterocolitica и Y. pseudotuberculosis, возбудителей кишечно-го иерсиниоза и псевдотуберкулеза, обладают схожими антигенными детерминантами [6][7][8]. Показано, что 8 белков Y. enteroсоlitiсa гомологичны с некоторыми аутоэпитоп-содержащими сегментами рТТГ, тиреоглобулина и тиреопероксидазы [7], обнаружена взаимная реактивность между белками иерсиний и антителами при БГ [7,9].…”

Section: обоснованиеunclassified

Yersinia infections and Graves’ disease

Khamnueva

Юрьевна²,

Гома

et al. 2018

Clin Exp Thyroid

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Background. The most common thyroid disease, accompanied by thyrotoxicosis syndrome, is Graves' disease (GD). Information about the role of Yersinia in the development of this disease is contradictory. Aims. To study the significance of Yersinia (Y.) enterocolitica and Y. pseudotuberculosis in the development of Graves' disease. Materials and methods. 78 patients with GD. Identification of antibodies to Y. was carried out by the following methods: 1. agglutination test (AT) with suspensions of live virulent cultures Y. pseudotuberculosis, Y. enterocolitica O:3 and O:9; 2. indirect hemagglutination test (IHET) with the use of erythrocyte diagnosticum; 3. determination of IgA and IgG antibodies against pathogenicity factors of Y. enterocolitica strains by immunoblotting (30 patients with GD). Results. Diagnostically significant titers of antibodies to Y. pseudotuberculosis and Y. enterocolitica were obtained in all patients with GD by AT. The greatest total thyroid volume determined by ultrasound investigation (p = 0.010) and the maximum duration of the disease (p = 0.040) were determined in the group of patients with the maximum antibody titer. No significant relation was found between the titer of antibodies to Yersinia and the levels of thyroid hormones stimulating the thyroid antibodies.The test for detection of IgA antibodies by immunoblotting was negative in 30 patients with GD (9 patients with a titer of antibodies by AT 1:800 – 1:1600, 17 – 1:400, 4 – 1:200). In all cases with the maximum antibody titer in AT, the positive IgG antibodies to the antigens YopM (Yop2a), YopH (Yop2b), V-antigen, YopD were found. The GD duration in patients with negative titers of antibodies by the immunoblotting test was less than with the positive one (p = 0.010). The privative clinical and anamnestic data and negative results by IHET confirmed the absence of active and/or transferred Yersinia infections in all the examined patients with GD. Conclusions. The cross-reacting antibodies to the antigens of Y. enterocolitica are determined in the serum of GD patients by AT and immunoblotting. The diagnostic titer of these antibodies is more often detected in patients with greater GD duration and larger volume of the thyroid gland. The absence of a link between the titer of these antibodies and the levels of thyroid hormones, the antibodies to the thyrotropin receptors of pituitary, as well as negative results by IHET with a diagnosticum that does not contain outer membrane proteins of pathogenic Yersinia, deny the trigger role of Yersinia infections as an initiating factor in the development of GD.

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“…The production of these autoantibodies can be attributed to both environmental and genetic factors [ 3 ]. Iodine overdose is the primary environmental cause [ 4 ], while bacterial and viral infections could be other causative factors [ 5 , 6 ]. Cross-reactive antigens can induce superantigen-activated polyclonal T cells, increase expression of human leukocyte antigen in thyroid tissue and promote other autoimmune tolerance responses [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases

et al. 2017

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ObjectiveThis study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).Materials and MethodsFifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.ResultsH. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72–2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07–3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (χ2 = 2.151, p = 0.143). Patients with Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68–4.61; HT: OR = 2.16, 95% CI: 1.44–3.23), while the rate of H. pylori infection did not differ between GD and HT (χ2 = 3.113, p = 0.078).ConclusionsH. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.

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Characterization of a RecombinantYersinia enterocoliticaLipoprotein; Implications for its Role in Autoimmune Response against Thyrotropin Receptor

Cited by 12 publications

References 14 publications

Concurrent reactive arthritis, Graves' disease, and warm autoimmune hemolytic anemia: a case report

Concurrent reactive arthritis, Graves' disease, and warm autoimmune hemolytic anemia: a case report

Yersinia infections and Graves’ disease

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases

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