Characterization of a rat osteotomy model with impaired healing

Kratzel, Christine; Bergmann, Camilla; Duda, Georg N.; Greiner, Stefan; Schmidmaier, Gerhard; Wildemann, Britt

doi:10.1186/1471-2474-9-135

Cited by 35 publications

(25 citation statements)

References 40 publications

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“…This discrepancy may be due to the fact that the model used by Brown et al [11] consisted of an open osteotomy with rotationally instable fixation, while in the present study we performed a closed fracture with a rotationally more stable fixation. In fact, rotationally unstable fixed osteotomies may not be ideal to study the process of fracture repair, because they are associated with delayed healing [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Obesity does not affect the healing of femur fractures in mice

Histing

Andonyan

Klein

et al. 2016

Injury

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Section: Discussionmentioning

confidence: 99%

Obesity does not affect the healing of femur fractures in mice

Histing

Andonyan

Klein

et al. 2016

Injury

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“…This is likely the reason that single growth factor therapies of fixed dose and limited duration exhibit limited therapeutic success: bone heals instead with a complex hierarchy of processes that involve complex pathways and dynamic dosing of multiple factors in close coordination. Clinically relevant small and large animal models of delayed bone healing are being utilized in an effort to better understand the cascades that lead to a healing delay or to non-unions [67–70]. Data from studies utilizing these animal models have indicated that all bone healing stages still occur during delayed bone healing, albeit with a difference in temporal onset and spatial distribution of callus tissue compared to normal healing subjects [71].…”

Section: Endogenous Mechanisms In Secondary Bone Healingmentioning

confidence: 99%

Biomaterial delivery of morphogens to mimic the natural healing cascade in bone

Mehta

Schmidt‐Bleek

Duda

et al. 2012

Advanced Drug Delivery Reviews

216

209

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Complications in treatment of large bone defects using bone grafting still remain. Our understanding of the endogenous bone regeneration cascade has inspired the exploration of a wide variety of growth factors (GFs) in an effort to mimic the natural signaling that controls bone healing. Biomaterial-based delivery of single exogenous GFs has shown therapeutic efficacy, and this likely relates to its ability to recruit and promote replication of cells involved in tissue development and the healing process. However, as the natural bone healing cascade involves the action of multiple factors, each acting in a specific spatiotemporal pattern, strategies aiming to mimic the critical aspects of this process will likely benefit from the usage of multiple therapeutic agents. This article reviews the current status of approaches to deliver single GFs, as well as ongoing efforts to develop sophisticated delivery platforms to deliver multiple lineage-directing morphogens (multiple GFs) during bone healing.

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“…Numerous animal models of nonunion fracture have been developed, to understand the pathogenesis of this condition and improve treatment [9][10][11][12][13][14][15]. Nevertheless, most of those models create purely mechanical disturbances, but not the metabolic pertubations that result in atrophic nonunion fracture [9].…”

Section: Introductionmentioning

confidence: 98%