Characterization of a Putative Ancestor of Coxsackievirus B5

Gullberg, Maria; Tolf, Conny; Jönsson, Nina; Mulders, Mick N.; Savolainen-Kopra, Carita; Hovi, Tapani; Ranst, Marc Van; Lemey, Philippe; Hafenstein, Susan; Lindberg, Anders

doi:10.1128/jvi.00071-10

Cited by 39 publications

(39 citation statements)

References 104 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The molecular evolutionary rates of several human enterovirus serotypes have been estimated to be 3 ϫ 10 Ϫ3 to 9 ϫ 10 Ϫ3 substitutions/site/year (28)(29)(30)(31). Since RNA viruses have an estimated mutation rate of between 10 Ϫ3 and 10 Ϫ5 substitutions/site/generation (32), this suggests that the molecular evolutionary rates of HEVs are higher than those of the other RNA viruses.…”

Section: Discussionmentioning

confidence: 99%

Emergence, Circulation, and Spatiotemporal Phylogenetic Analysis of Coxsackievirus A6- and Coxsackievirus A10-Associated Hand, Foot, and Mouth Disease Infections from 2008 to 2012 in Shenzhen, China

et al. 2013

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Emergence, Circulation, and Spatiotemporal Phylogenetic Analysis of Coxsackievirus A6- and Coxsackievirus A10-Associated Hand, Foot, and Mouth Disease Infections from 2008 to 2012 in Shenzhen, China

et al. 2013

View full text Add to dashboard Cite

“…1). The clade close to the tree root was given the letter A (genogroup CVB5-A) and corresponds to genogroup II in an earlier study (31). The two clades had different phylogenetic patterns.…”

Section: Phylogenetic Clustering Of Cvb5 Taxa In the 1dmentioning

confidence: 99%

“…Acute meningitis is the typical clinical presentation in CVB5 outbreaks, but the virus was recently involved in an outbreak of neurological hand, foot, and mouth disease in China (28). Previous studies have provided some insight into the genetic diversity within CVB5 (29,30), and a phylogenetic analysis of the 1D VP1 genes sampled in 41 clinical isolates showed that CVB5 had an estimated origin in 1854 (31). We explored the evolutionary process that shapes the genetic diversity of CVB5 with a larger virus sample and identified variations in the genetic diversity and phylodynamic patterns of two virus lineages, genogroups A and B, involved in seasonal epidemics in Europe.…”

mentioning

confidence: 99%

Phylogenetic Patterns of Human Coxsackievirus B5 Arise from Population Dynamics between Two Genogroups and Reveal Evolutionary Factors of Molecular Adaptation and Transmission

Henquell

Mirand

Richter

et al. 2013

J Virol

View full text Add to dashboard Cite

The aim of this study was to gain insights into the tempo and mode of the evolutionary processes that sustain genetic diversity in coxsackievirus B5 (CVB5) and into the interplay with virus transmission. We estimated phylodynamic patterns with a large sample of virus strains collected in Europe by Bayesian statistical methods, reconstructed the ancestral states of genealogical nodes, and tested for selection. The genealogies estimated with the structural one-dimensional gene encoding the VP1 protein and nonstructural 3CD locus allowed the precise description of lineages over time and cocirculating virus populations within the two CVB5 clades, genogroups A and B. Strong negative selection shaped the evolution of both loci, but compelling phylogenetic data suggested that immune selection pressure resulted in the emergence of the two genogroups with opposed evolutionary pathways. The genogroups also differed in the temporal occurrence of the amino acid changes. The virus strains of genogroup A were characterized by sequential acquisition of nonsynonymous changes in residues exposed at the virus 5-fold axis. The genogroup B viruses were marked by selection of three changes in a different domain (VP1 C terminus) during its early emergence. These external changes resulted in a selective sweep, which was followed by an evolutionary stasis that is still ongoing after 50 years. The inferred population history of CVB5 showed an alternation of the prevailing genogroup during meningitis epidemics across Europe and is interpreted to be a consequence of partial cross-immunity.

show abstract

“…2. Published VP1 substitution rates for coxsackievirus B5 (CVB5), echovirus 9 (E9), echovirus 11 (E11), echovirus 30 (E30), HAV, and HPeV were obtained via BEAST analyses similar to those used in this study (15,23,34,(46)(47)(48); those for EV71, FMDV-A, and FMDV-O were obtained via analyses performed in TipDate (58), a precursor to BEAST (29); and the remaining rates were estimated via linear regression (3,4,44,50,66,70,71). These mean rates of enterovirus VP1 evolution range from 3.40 ϫ 10 Ϫ3 to 1.19 ϫ 10 Ϫ2 nucleotide substitutions per site per year (ns/s/y), and mean VP1 rates for nonenteroviruses range from 9.76 ϫ 10 Ϫ4 to 2.79 ϫ 10 Ϫ3 ns/s/y.…”

mentioning

confidence: 99%

Genus-Specific Substitution Rate Variability among Picornaviruses

Hicks

Duffy

2011

J Virol

View full text Add to dashboard Cite

Picornaviruses have some of the highest nucleotide substitution rates among viruses, but there have been no comparisons of evolutionary rates within this broad family. We combined our own Bayesian coalescent analyses of VP1 regions from four picornaviruses with 22 published VP1 rates to produce the first within-family meta-analysis of viral evolutionary rates. Similarly, we compared our rate estimates for the RNA polymerase 3D pol gene from five viruses to four published 3D pol rates. Both a structural and a nonstructural gene show that enteroviruses are evolving, on average, a half order of magnitude faster than members of other genera within the Picornaviridae family.Members of the Picornaviridae family are the most common cause of human viral infections in developed countries (28,39). Human picornaviruses produce symptoms ranging from mild respiratory illness to hemorrhagic conjunctivitis, myocarditis, acute flaccid paralysis, and neonatal organ failure (19,27,28,33,40,41). Veterinary picornaviruses, such as foot-and-mouth disease virus (FMDV), encephalomyocarditis virus (EMCV), and porcine teschovirus (PTV), can have devastating effects on livestock (5,8,21).Although picornaviruses such as poliovirus (PV) are known to evolve more rapidly than other viruses with single-stranded RNA (ssRNA) genomes (9, 29), little research has been conducted to investigate how they evolve more rapidly than other viruses with similarly error-prone RNA-dependent RNA polymerases (29, 57) or if certain picornaviruses evolve more rapidly than others. Understanding the evolutionary potentials and constraints of these important pathogens is imperative for the development of durable vaccines and effective treatment plans for individual pathogens (42). As even small, 3-fold differences in RNA virus mutation rates can have dramatic consequences, such as driving a population into lethal mutagenesis (7), similar differences in long-term evolutionary rates could indicate significantly dissimilar evolutionary potentials.While viral evolutionary rates were previously calculated only by linear regression, modern simulation software such as BEAST (11) allows for the estimation of more complex models of viral evolution. These Bayesian coalescent programs can produce both estimated mean rates of evolution and 95% credibility intervals (CIs) that provide a measure of the variability around mean rates. Instead of comparing single-point estimates, now nonoverlapping CIs provide the strongest evidence that genes or organisms are evolving at different rates (11). Many substitution rate estimates have been published for picornaviruses, especially for the antigenically significant VP1 gene, which encodes the most external of the picornavirus structural proteins and interacts with cellular receptors (37,49). Based on sequence availability in GenBank, four novel analyses were conducted, measuring the rate of evolution of the VP1 gene for two enteroviruses and producing the first rate estimates for the type species of the genera Cardiovirus and Teschoviru...

show abstract

Characterization of a Putative Ancestor of Coxsackievirus B5

Cited by 39 publications

References 104 publications

Emergence, Circulation, and Spatiotemporal Phylogenetic Analysis of Coxsackievirus A6- and Coxsackievirus A10-Associated Hand, Foot, and Mouth Disease Infections from 2008 to 2012 in Shenzhen, China

Emergence, Circulation, and Spatiotemporal Phylogenetic Analysis of Coxsackievirus A6- and Coxsackievirus A10-Associated Hand, Foot, and Mouth Disease Infections from 2008 to 2012 in Shenzhen, China

Phylogenetic Patterns of Human Coxsackievirus B5 Arise from Population Dynamics between Two Genogroups and Reveal Evolutionary Factors of Molecular Adaptation and Transmission

Genus-Specific Substitution Rate Variability among Picornaviruses

Contact Info

Product

Resources

About