Characterization of a polypurine/polypyrimidine sequence upstream of the mouse metallothionein-I gene

Becker, Nicole A.; Maher, L. James

doi:10.1093/nar/26.8.1951

Cited by 8 publications

(1 citation statement)

References 41 publications

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“…Their origin and eventual function is unknown, although G + C‐rich sequences, not particularly polypurine/polypyrimidine tracts, may represent recombinogenic mobile elements, as suggested by others in S. cerevisiae (Dieckmann and Gandy, 1987; Weiller et al , 1989). This sequence feature was found associated sometimes to mouse genes (Becker et al , 1998) or human genes (Rustighi et al , 2002), and is supposed to function as a possible transcription regulator. Such tracts stimulate D‐loop formation (Biet et al , 2003), eventually enhancing functions such as recombination, transcription or initiation of DNA replication.…”

Section: Discussionmentioning

confidence: 98%

The mitochondrial genome from the thermal dimorphic fungus Paracoccidioides brasiliensis

Cardoso

Tambor

Nóbrega

2007

Yeast

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We present here the sequence of the mitochondrial DNA of the pathogenic thermodimorphic fungus Paracoccidioides brasiliensis, agent of an endemic disease in most South American countries. The sequenced genome has 71 334 bp and is organized as a circular molecule with two gaps of unknown size flanking the middle exon of the nad5 gene. We located genes coding for the three subunits of the ATP synthase (atp6, atp8 and atp9 ), the apocytochrome b (cob), three subunits of the cytochrome c oxidase enzyme complex (cox1, cox2 and cox3 ), seven subunits of the reduced nicotinamide adenine dinucleotide ubiquinone oxidoreductase (nad1, nad2, nad3, nad4, nad5, nad6 and nad4L) and the large (rnl ) and small (rns) subunits of ribosomal RNA. Two maturases and a ribosomal protein (rms5 ) are located inside introns. Twenty-five tRNAs were identified with acceptors for all 20 amino acids. Seven polypurine/polypyrimidine tracts (140-240 bp) have been found in this genome. All genes are in the same orientation over the genome, while their order is closest to the mitochondrial genomes from Penicillium marneffei and Aspergillus nidulans. This sequence is available under GenBank Accession No. AY955840.

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