Characterization of a polymer-stabilized liposome system

Heldt, Nicole; Gauger, Michele; Zhao, Jiawen; Slack, Gregory C.; Pietryka, John; Li, Y

doi:10.1016/s1381-5148(01)00055-4

Cited by 17 publications

(15 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To evaluate the size distribution, PDI, and value ZP of each sample, 50 mg of liposome was weighted and dispersed in 20 mL distilled water and then those parameters were measured by the zetasizer (Zetasizer Nanoseries, Malbern Instrument) [ 18 – 20 ]. This test was repeated thrice.…”

Section: Methodsmentioning

confidence: 99%

Development and Characterization of Liposomal Doxorubicin Hydrochloride with Palm Oil

Sabeti

Noordin

Mohd

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

The usage of natural products in pharmaceuticals has steadily seen improvements over the last decade, and this study focuses on the utilization of palm oil in formulating liposomal doxorubicin (Dox). The liposomal form of Dox generally minimizes toxicity and enhances target delivery actions. Taking into account the antiproliferative and antioxidant properties of palm oil, the aim of this study is to design and characterize a new liposomal Dox by replacing phosphatidylcholine with 5% and 10% palm oil content. Liposomes were formed using the freeze_thaw method, and Dox was loaded through pH gradient technique and characterized through in vitro and ex vivo terms. Based on TEM images, large lamellar vesicles (LUV) were formed, with sizes of 438 and 453 nm, having polydispersity index of 0.21 ± 0.8 and 0.22 ± 1.3 and zeta potentials of about −31 and −32 mV, respectively. In both formulations, the entrapment efficiency was about 99%, and whole Dox was released through 96 hours in PBS (pH = 7.4) at 37°C. Comparing cytotoxicity and cellular uptake of LUV with CaelyxR on MCF7 and MDA-MBA 231 breast cancer cell lines indicated suitable uptake and lower IC50 of the prepared liposomes.

show abstract

Section: Methodsmentioning

confidence: 99%

Development and Characterization of Liposomal Doxorubicin Hydrochloride with Palm Oil

Sabeti

Noordin

Mohd

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The first step of this strategy is to screen and qualitatively identify the bioavailable herbal components (what are absorbed). As reported, the commonly used models in the field of drug permeability and absorption are mainly Caco-2 cells [54][55][56] and liposomes [57][58][59][60][61][62]. These models coupled with analytical technologies, such as LC-TOF/MS, LC-QTOF/MS and LC-IT-TOF/MS, are potent tools for screening and identifying bioavailable components from HMs.…”

Section: Proposed Strategy: "Chemical Fishing" Based Strategy For Metmentioning

confidence: 99%

Strategies for Integral Metabolism Profile of Multiple Compounds in Herbal Medicines: Pharmacokinetics, Metabolites Characterization and Metabolic Interactions

Xin

Qi²,

Shi³

et al. 2011

CDM

View full text Add to dashboard Cite

Herbal medicines (HMs) are gaining more and more attention all over the world, because of their significant curative effect in treating multi-factorial diseases. Recently, the in vivo and in vitro metabolism study of HMs has become an important issue because these data can help us to better understand the efficacies and toxicities of HMs. However, the integral metabolism profile of HMs is confronted with many challenges: 1) HM is a multi-component system; 2) most components are unknown (nontarget); 3) trace of components in HM. Given the challenges described above, the demand for more powerful bioanalytical tools and strategies that are adequate for integral metabolism profile of HMs' multi-components has increased. In the past few years, newer methods, or adaptations to methods, have been published, and this review will attempt to discuss new improvements in strategies and methodologies for HMs' multi-component ADME evaluation. In particular, improvements have been reported for experimental approaches to pharmacokinetics study of HMs, as well as strategies applied to metabolites characterization of HMs' multi-components, and the metabolic interactions between ingredients in HMs, including advance and proposed strategy: "chemical fishing" based strategy for metabolic interactions of HMs.

show abstract

“…Pulsed field gradient NMR (PFG-NMR) is a powerful, nondestructive technique of measuring self-diffusion coefficients in a colloidal dispersion [69][70][71]. Molecules associated with an aggregate or a particle will diffuse more slowly than their free dissolving state.…”

Section: Dynamic Nuclear Magnetic Resonancementioning

confidence: 99%

Current and Future Challenges in CMP Materials

Moinpour

2007

Microelectronic Applications of Chemical Mechanical Planarization

View full text Add to dashboard Cite

Chemical-mechanical polishing (CMP) has emerged as the premier technique for achieving both local and global planarizations in silicon integrated circuit (Si IC) manufacturing. With the transition of Si IC fabrication industry to using sub-half-micron devices in the late 1990s, the CMP market size has grown rapidly, from about $300-400 millions in 1997 to over $2 billions in 2002 and is predicted to be over $3 billions by 2008 [1]. Among the $3 billions, roughly half belongs to equipment related to CMP, such as polishers and metrology tools. The other half is associated with materials such as slurries and pads ( Fig. 2.1). Another recent market research study predicts the CMP slurry/ pad market size to be around $1.8 billions by 2009 presenting a CAGR of 16% and 17% for slurries and pads, respectively, driven primarily by the rise of copper CMP and transition to 300 mm wafer size (Fig. 2.2) [2]. Similar to other semiconductor sectors, the CMP community faces constant challenges in the identification, selection, characterization, and qualification of materials. They are vital to the success of implementing and sustaining the CMP processes in the ever-competitive global semiconductor manufacturing environment.To put the topic in perspective, the market size of the materials related to semiconductor manufacturing is now over 10 billions USD [3]. Among these key materials, the sum of CMP slurry and pad is over 11%, which is approaching the combination of photoresist and stripping chemicals (Fig. 2.3). On the one hand, this is a strong indication that CMP technology has become a Microelectronic Applications of Chemical Mechanical Planarization, Edited by Yuzhuo Li

show abstract

Characterization of a polymer-stabilized liposome system

Cited by 17 publications

References 16 publications

Development and Characterization of Liposomal Doxorubicin Hydrochloride with Palm Oil

Development and Characterization of Liposomal Doxorubicin Hydrochloride with Palm Oil

Strategies for Integral Metabolism Profile of Multiple Compounds in Herbal Medicines: Pharmacokinetics, Metabolites Characterization and Metabolic Interactions

Current and Future Challenges in CMP Materials

Contact Info

Product

Resources

About