Characterization of a novel wood mouse virus related to murid herpesvirus 4

Hughes, David J.; Kipar, Anja; Milligan, Steven G.; Cunningham, Charles; Sanders, Mandy; Quail, Michael A.; Rajandream, Marie Adèle; Efstathiou, Stacey; Bowden, Rory; Chastel, C; Bennett, Malcolm J.; Sample, Jeffery T.; Barrell, Bart; Davison, Andrew J.; Stewart, James P.

doi:10.1099/vir.0.017327-0

Cited by 32 publications

(34 citation statements)

References 69 publications

(80 reference statements)

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“…The archetypal MHV-68 strain was originally isolated from bank voles (Myodes glareolus) in Slovakia (Blaskovic et al, 1980) together with four other MuHV-4 strains, MHV-60 and -72 also isolated from bank voles and MHV-76 and -78 isolated from yellow-necked mice (Apodemus flavicollis). More recently, closely related viruses have been isolated from shrew (Crocidura russula) (Chastel et al, 1994) and wood mouse (Apodemus sylvaticus) (Blasdell et al, 2003;Hughes et al, 2010b).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of murid gammaherpesvirus 4 infection in mice and in a natural host, bank voles

François

Vidick

Sarlet

et al. 2010

Journal of General Virology

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Gammaherpesviruses are archetypal pathogenic persistent viruses. The known human gammaherpesviruses (Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus) are host-specific and therefore lack a convenient in vivo infection model. This makes related animal gammaherpesviruses an important source of information. Infection by murid herpesvirus 4 (MuHV-4), a virus originally isolated from bank voles (Myodes glareolus), was studied here. MuHV-4 infection of inbred laboratory mouse strains (Mus musculus) is commonly used as a general model of gammaherpesvirus pathogenesis. However, MuHV-4 has not been isolated from house mice, and no systematic comparison has been made between experimental MuHV-4 infections of mice and bank voles. This study therefore characterized MuHV-4 (strain MHV-68) infection of bank voles through global luciferase imaging and classical virological methods. As in mice, intranasal virus inoculation led to productive replication in bank vole lungs, accompanied by massive cellular infiltrates. However, the extent of lytic virus replication was approximately 1000-fold lower in bank voles than in mice. Peak latency titres in lymphoid tissue were also lower, although latency was still established. Finally, virus transmission was tested between animals maintained in captivity. However, as observed in mice, MuHV-4 was not transmitted between voles under these conditions. In conclusion, this study revealed that, despite quantitative differences, replication and the latency sites of MuHV-4 are comparable in bank voles and mice. Therefore, it appears that, so far, Mus musculus represents a suitable host for studying gammaherpesvirus pathogenesis with MuHV-4. Establishing transmission conditions in captivity will be a vital step for further research in this field.

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Section: Introductionmentioning

confidence: 99%

Comparative study of murid gammaherpesvirus 4 infection in mice and in a natural host, bank voles

François

Vidick

Sarlet

et al. 2010

Journal of General Virology

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“…The GHV subfamily of herpesviruses includes Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), herpesvirus Saimiri (HVS), rhesus rhadinovirus (RRV), murine gammaherpesvirus 68 (MHV68 [also referred to as ␥HV68]), and two recently isolated rodent viruses, wood mouse herpesvirus and herpesvirus Peru (22,29). Infections by the human pathogens EBV and KSHV are etiologically associated with numerous diseases, including a staggering list of cancers and tumors (10,31).…”

mentioning

confidence: 99%

Amplification of JNK Signaling Is Necessary To Complete the Murine Gammaherpesvirus 68 Lytic Replication Cycle

Stahl

Paden

Chavan

et al. 2012

J Virol

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Several studies have previously defined host-derived signaling events capable of driving lytic gammaherpesvirus replication or enhancing immediate-early viral gene expression. Yet signaling pathways that regulate later stages of the productive gammaherpesvirus replication cycle are still poorly defined. In this study, we utilized a mass spectrometric approach to identify c-Jun as an abundant cellular phosphoprotein present in late stages of lytic murine gammaherpesvirus 68 (MHV68) infection. Kinetically, c-Jun phosphorylation was enhanced as infection progressed, and this correlated with enhanced phosphorylation of the c-Jun amino-terminal kinases JNK1 and JNK2 and activation of AP-1 transcription. These events were dependent on progression beyond viral immediate-early gene expression, but not dependent on viral DNA replication. Both pharmacologic and dominantnegative blockade of JNK1/2 activity inhibited viral replication, and this correlated with inhibition of viral DNA synthesis and reduced viral gene expression. These data suggest a model in which MHV68 by necessity amplifies and usurps JNK/c-Jun signaling as infection progresses in order to facilitate late stages of the MHV68 lytic infection cycle.

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“…Another gammaherpesvirus named Brest herpesvirus (BRHV), isolated from a whitetoothed shrew (Crocidura russula) was partially sequenced and gave a 99.25% identity with WMHV. Also the pathogenesis of WMHV in wood mice was very similar to that of MHV-68 (Hughes et al, 2010). Thus WMHV and BRHV were considered strains of a new virus species.…”

Section: The Virusmentioning

confidence: 77%

Possible role of different animal species in maintenance and spread of murine gammaherpesvirus 68 in the nature

Wagnerová¹,

Chalupková²,

Hrabovská³

et al. 2015

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Summary. -Murine gammaherpesvirus 68 (MHV-68), isolated from a bank vole (Clethrionomys glareolus)in Slovakia in 1976 is a natural pathogen of wild murid rodents. This review is focused to biological properties of this pathogen, the mode of its maintenance in murid rodents as reservoir animals, mechanisms of its spread to other animals in the same biotope as well as to livestock and household animals. Potential role of ticks as vectors and the possibility of infection of humans with this virus are considered as well. All the above evidence of the virus infection of various hosts is based on serological or molecular analytical data. The presented knowledge indicates important epizootologic consequences, namely harboring and permanent maintenance of the virus in murid rodents as reservoir animals with a real possibility of spread to other animals in the same biotope. These relationships imply a cross-species virus transmission with potential serious consequences for the infected animals or humans.

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Characterization of a novel wood mouse virus related to murid herpesvirus 4

Cited by 32 publications

References 69 publications

Comparative study of murid gammaherpesvirus 4 infection in mice and in a natural host, bank voles

Comparative study of murid gammaherpesvirus 4 infection in mice and in a natural host, bank voles

Amplification of JNK Signaling Is Necessary To Complete the Murine Gammaherpesvirus 68 Lytic Replication Cycle

Possible role of different animal species in maintenance and spread of murine gammaherpesvirus 68 in the nature

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