Characterization of a novel particle into liquid sampler for analysis of single fluorescent aerosol particles through capillary electrophoresis

The Molecular Identification of Organic Compounds in the Atmosphere: State of the Art and Challenges

“…With this technique, both inorganic and organic ions, such as carboxylic acids, ,, can be separated in a single run. Other advantages, especially for atmospheric applications, include the requirement of only small sample amounts, such as a single drop of rain or fog, the broad linear detection range, and the absence of extensive sample preparation, even for complex compounds such as HULIS. , CE is usually coupled with UV–vis , or conductivity detectors, but coupling with MS has also been performed. − However, the buffers used in CE separation can interfere with the MS ionization process, and the use of sheath liquid can lead to a loss of MS sensitivity. The second problem could be avoided by coupling CE to nanospray interfaces.…”

Capillary Electrophoresis

“…Tang et al. developed an approach for sampling and analyzing single aerosolized droplets of solution for CE–laser induced fluorescence (LIF) separation and detection . Sample particles were accelerated through a nozzle into a small drop of buffered solution, and upon dissolution a portion of the sample was injected.…”

“…Tang et al developed an approach for sampling and analyzing single aerosolized droplets of solution for CE−laser induced fluorescence (LIF) separation and detection. 8 Sample particles were accelerated through a nozzle into a small drop of buffered solution, and upon dissolution a portion of the sample was injected. The approach was used to analyze droplets, smaller than 10 nL in volume, containing fluorescein isothiocyanate (FITC) labeled glycine and glutamic acid.…”

Aerosol Electroanalysis by PILSNER: Particle-into-Liquid Sampling for Nanoliter Electrochemical Reactions

“…Analytes in the aerosol are extracted by this sampling volume, and the resulting sample is analyzed by another technique, such as mass spectrometry 13 or fluorescence. 14 Despite its analytical power, PILS is limited by both the relatively large volume into which particles are usually sampled (usually on the order of mL, creating a large dilution factor for analytes) as well as its off-line nature. If techniques are developed to probe smaller sampling volumes, the limit of detection (LOD) of PILS can be driven down by orders of magnitude.…”

“…In this technique, particles are impacted onto a liquid interface and incorporated into the bulk solution (or sampling volume). Analytes in the aerosol are extracted by this sampling volume, and the resulting sample is analyzed by another technique, such as mass spectrometry or fluorescence . Despite its analytical power, PILS is limited by both the relatively large volume into which particles are usually sampled (usually on the order of mL, creating a large dilution factor for analytes) as well as its off-line nature.…”