Characterization of a novel murine testis-specific serine/threonine kinase

GAK: a cyclin G associated kinase contains a tensin/auxilin‐like domain1

“…The amino acid sequence of the cDNA, as deduced from the DNA sequence, indicated that the structure of the kinase domain closely resembles that of Nek 1 [12], CDK2 [2,13,14], Plk [14] and Tsk-1 [15] kinases (Fig. 1A,B).…”

Makings of the Best Spermatozoa: Molecular Determinants of High Fertility

“…The expression of Izumo was found to be testisspecific and was not detectable on the surface of fresh sperm but only became apparent after initiation of the acrosome reaction (Rubinstein et al, 2006) In addition, a number of enzymes mediating the process of spermatogenesis have also been discovered. The Testis Specific Serine Kinases (TSSKs) are a collection of kinases in germ cells or in testis, which include TSSK1, TSSK2, TSSK3 and others (Bielke et al, 1994;Blaschke et al, 1994;Kueng et al, 1997;Zuercher et al, 2000). Since Specific Serine Kinases are only synthesized postmeiotically in spermatogenesis, they were proposed to act during sperm maturation, capacitation and fertilization.…”

c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population

“…Through phosphorylation of proteins, the testis-specific serine/threonine kinase (TSSK) family, which is expressed abundantly in the testis, is deeply involved in sperm differentiation, capacitation and fertilization [6][7][8][9][10][11]. Up to now, five members of this family have been identified, including TSSK1, TSSK2, TSSK3, TSSK4 and TSSK6.…”